利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

43 条记录 (耗时 0.034 秒)

    Inhibitor(s) of transporters or uptake of monoaminergic neurotransmitters
    9.
    发明授权
    Inhibitor(s) of transporters or uptake of monoaminergic neurotransmitters 有权
    转运蛋白的抑制剂或单胺能神经递质的摄取

    公开(公告)号：US08772330B2

    公开(公告)日：2014-07-08

    申请号：US13355371

    申请日：2012-01-20

    申请人： James David White ,  David T. Wong ,  David B. Chan ,  Jongtae Yang ,  Rajan Juniku

    发明人： James David White ,  David T. Wong ,  David B. Chan ,  Jongtae Yang ,  Rajan Juniku

    IPC分类号： A61K31/381 ,  C07D333/16

    CPC分类号： A61K31/381 ,  C07D333/16 ,  C07D333/20 ,  C07D333/24

    摘要： The present disclosure concerns a compound, or a pharmaceutically acceptable salt thereof, having a formula: where at least one of R1-R4 is a heterocycle, at least one of R1-R4 is an aryl group coupled to the ring by a linker atom, functional group, or other moiety, or where none of R1-R4 is an amide, and any and all combinations thereof. Remaining R1-R4 substituents independently are aliphatic, substituted aliphatic, amine, substituted amine, aryl, substituted aryl, cyclic, substituted cyclic, halide, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, hydrogen or hydroxyl. A method for treating a subject also is provided comprising administering a disclosed compound or compounds, or a prodrug that is converted into the disclosed compound or compounds, or a composition comprising the compound, compounds, or prodrugs thereof, to a subject. A method for making disclosed compounds also is provided.

    摘要翻译： 本公开涉及具有下式的化合物或其药学上可接受的盐：其中R 1 -R 4中的至少一个是杂环，R 1 -R 4中的至少一个是通过连接原子与环偶联的芳基， 官能团或其它部分，或者其中没有R 1 -R 4是酰胺，以及其任何和所有组合。 残留的R 1 -R 4取代基独立地是脂族，取代的脂族，胺，取代的胺，芳基，取代的芳基，环状，取代的环状，卤素，杂芳基，取代的杂芳基，杂环，取代的杂环，氢或羟基。 还提供了治疗受试者的方法，其包括向受试者施用公开的化合物或化合物，或将其转化为所公开的化合物或化合物的前体药物或包含其化合物，化合物或前药的组合物。 还提供了制备公开化合物的方法。