Characterizing biological matter in a dynamic condition using near
infrared spectroscopy
    2.
    发明授权
    Characterizing biological matter in a dynamic condition using near infrared spectroscopy 失效
    使用近红外光谱法在动态条件下表征生物物质

    公开(公告)号:US5830133A

    公开(公告)日:1998-11-03

    申请号:US476129

    申请日:1995-06-07

    摘要: A method for predicting a property of biological matter, such as biological fluid, containing water, in a dynamic condition where the biological fluid may be approximated to contain two compartments where one compartment has a proportionally larger or smaller amount of water than the other compartment having the property of interest. The method involves establishing a training set in the near-infrared (NIR) region with independent quantification of the property of the fluid using known techniques. The training set is mathematically analyzed according to a correlation developed by regression analysis after employment of a pre-processing technique such as a multiple derivative transformation of spectra or a ratioing of two wavelengths in the spectra. The result is a mathematical transformation equation which quantitatively relates spectral intensities at specific wavelengths to the property of interest. This transformation equation may be applied to unknown samples so as to predict their properties, thereby eliminating need for the reference method except for validation or recalibration. The method provides rapid and accurate prediction of the property of the unknown sample, which may be the property of hematocrit or hemoglobin concentration in whole animal blood. Other analyses of properties in the biological fluid such as oxygen saturation in hemoglobin in whole animal blood may be included in the mathematical analysis to further refine the prediction of the property of interest. Also, a loop from the patient is disclosed for the purpose of monitoring the property of interest nearly simultaneously with changes in that property of interest.

    摘要翻译: 一种在生物流体近似的动态条件下预测生物物质的生物物质的性质的方法,所述生物物质可以近似于包含两个隔室,其中一个隔室具有比其他具有比例地更大或更小量的水, 感兴趣的财产。 该方法包括在近红外(NIR)区域中建立训练集,并使用已知技术独立定量流体的性质。 根据在使用光谱的多重导数变换或光谱中两个波长的比例的预处理技术之后的回归分析所产生的相关性,对训练集进行数学分析。 结果是数学变换方程,其定量地将特定波长的光谱强度与感兴趣的属性相关联。 该变换方程可以应用于未知样本,以便预测它们的性质,从而消除了除了验证或重新校准之外的参考方法的需要。 该方法提供了对未知样品的性质的快速和准确的预测,其可以是整个动物血液中血细胞比容或血红蛋白浓度的特性。 在整个动物血液中血液中血液中氧饱和度等生物流体性质的其他分析可能包括在数学分析中,以进一步完善感兴趣的物质的预测。 此外,为了与感兴趣的属性的变化几乎同时地监视感兴趣的属性,公开了来自患者的循环。

    Characterizing biological matter in a dynamic condition using near
infrared spectroscopy spectrum
    3.
    发明授权
    Characterizing biological matter in a dynamic condition using near infrared spectroscopy spectrum 失效
    使用近红外光谱谱在动态条件下表征生物物质

    公开(公告)号:US5729333A

    公开(公告)日:1998-03-17

    申请号:US995951

    申请日:1992-12-22

    摘要: A method is provided for predicting a property of a matter of biological origin, such as biological fluid, containing water, in a dynamic condition where the biological fluid may be approximated to contain two compartments where one compartment has a proportionally larger or smaller amount of water than the other compartment having the property of interest. The method involves establishing a training set in the near-infrared (NIR) region with independent quantification of the property of the fluid using known techniques. The training set is mathematically analyzed according to a correlation developed by regression analysis after employment of a pre-processing technique such as a multiple derivative transformation of spectra or a ratioing of two wavelengths in the spectra. The result is a mathematical transformation equation which quantitatively relates spectral intensities at specific wavelengths to the property of interest. This transformation equation may be applied to unknown samples so as to predict their properties, thereby eliminating need for the reference method except for validation or recalibration. The method provides rapid and accurate prediction of the property of the unknown sample, which may be the property of hematocrit or hemoglobin concentration in whole animal blood. Other analyses of properties in the biological fluid such as oxygen saturation in hemoglobin in whole animal blood may be included in the mathematical analysis to further refine the prediction of the property of interest. Also, a loop from the patient is disclosed for the purpose of monitoring the property of interest nearly simultaneously with changes in that property of interest.

    摘要翻译: 提供了一种用于在生物流体近似的动态条件下预测生物来源的生物流体物质的生物流体的性质的方法,所述动态条件可以包含两个室,其中一个隔室具有比例地较大或较小量的水 比具有感兴趣性质的另一个隔间。 该方法包括在近红外(NIR)区域中建立训练集,并使用已知技术独立定量流体的性质。 根据在使用光谱的多重导数变换或光谱中两个波长的比例的预处理技术之后的回归分析所产生的相关性,对训练集进行数学分析。 结果是数学变换方程,其定量地将特定波长的光谱强度与感兴趣的属性相关联。 该变换方程可以应用于未知样本,以便预测它们的性质,从而消除了除了验证或重新校准之外的参考方法的需要。 该方法提供了对未知样品的性质的快速和准确的预测,其可以是整个动物血液中血细胞比容或血红蛋白浓度的特性。 在整个动物血液中血液中血液中氧饱和度等生物流体性质的其他分析可能包括在数学分析中,以进一步完善感兴趣的物质的预测。 此外,为了与感兴趣的属性的变化几乎同时地监视感兴趣的属性,公开了来自患者的循环。

    Method for the prediction of properties of biological matter by analysis
of the near-infrared spectrum thereof
    4.
    发明授权
    Method for the prediction of properties of biological matter by analysis of the near-infrared spectrum thereof 失效
    通过分析其近红外光谱来预测生物物质性质的方法

    公开(公告)号:US5706208A

    公开(公告)日:1998-01-06

    申请号:US995543

    申请日:1992-12-22

    CPC分类号: G01N21/359 G01N33/492

    摘要: A method for predicting a property of a matter of biological origin, such as biological fluid, containing water, where the biological matter may be approximated to contain two compartments where one compartment has a proportionally larger or smaller amount of water than the other compartment having the property of interest. The method establishes a training set in the near-infrared (NIR) region with independent quantification of the property of the matter using known techniques. The training set is mathematically analyzed according to a correlation developed by regression analysis after employment of a ratio pre-processing technique. The result is a mathematical transformation equation which quantitatively relates spectral intensities at specific wavelengths to the property of interest. This transformation equation may be applied to unknown samples so as to predict their properties, thereby eliminating need for the reference method except for validation or recalibration. There is rapid and accurate prediction of the property of the unknown sample, which may be the property of hematocrit or hemoglobin concentration in whole animal blood.

    摘要翻译: 一种用于预测生物来源物的性质的方法,例如含有水的生物流体,其中生物物质近似可以包含两个隔室,其中一个隔室具有比具有比例更大或更小量的水, 感兴趣的财产。 该方法在近红外(NIR)区域中建立了一个使用已知技术独立量化物质属性的训练集。 在使用比例预处理技术后,根据回归分析发展的相关性对数据进行数学分析。 结果是数学变换方程,其定量地将特定波长的光谱强度与感兴趣的属性相关联。 该变换方程可以应用于未知样本,以便预测它们的性质,从而消除了除了验证或重新校准之外的参考方法的需要。 对未知样品的性质进行快速准确的预测,这可能是整个动物血液中血细胞比容或血红蛋白浓度的特性。