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公开(公告)号:US20050014793A1
公开(公告)日:2005-01-20
申请号:US10900489
申请日:2004-07-28
申请人: Deirdre Hickey , Robert Ife , Colin Leach , John Liddle , Ivan Pinto , Stephen Smith , Steven Stanway
发明人: Deirdre Hickey , Robert Ife , Colin Leach , John Liddle , Ivan Pinto , Stephen Smith , Steven Stanway
IPC分类号: C07D215/20 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61P3/10 , A61P9/00 , A61P9/10 , A61P19/02 , A61P29/00 , C07D211/74 , C07D215/36 , C07D221/04 , C07D401/12 , C07D471/04 , C07D495/04 , C07D513/04 , A61K31/4439 , C07
CPC分类号: C07D221/04 , C04B35/632 , C07D211/74 , C07D215/36 , C07D401/12 , C07D471/04 , C07D495/04 , C07D513/04
摘要: Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis. Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
摘要翻译: 式(I)化合物:是Lp-PLA2酶的抑制剂,可用于治疗,特别是治疗动脉粥样硬化。 式(I)化合物:是Lp-PLA2酶的抑制剂,可用于治疗,特别是治疗动脉粥样硬化。
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公开(公告)号:US20070123549A1
公开(公告)日:2007-05-31
申请号:US11561926
申请日:2006-11-21
申请人: Deirdre Hickey , Robert Ife , Colin Leach , Ivan Pinto , Stephen Smith , Steven Stanway
发明人: Deirdre Hickey , Robert Ife , Colin Leach , Ivan Pinto , Stephen Smith , Steven Stanway
IPC分类号: A61K31/513 , C07D239/47
CPC分类号: C07D239/56 , C07D239/60 , C07D239/70 , C07D239/95 , C07D401/12 , C07D403/12 , C07D495/04
摘要: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.
摘要翻译: 式(I)的嘧啶酮化合物:是Lp-PLA 2酶的抑制剂,可用于治疗动脉粥样硬化。
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公开(公告)号:US20050043335A1
公开(公告)日:2005-02-24
申请号:US10494509
申请日:2002-11-08
申请人: Richard Elliott , Deidre Hickey , Robert Ife , Colin Leach , John Liddle , Ivan Pinto , Stephen Smith , Steven Stanway
发明人: Richard Elliott , Deidre Hickey , Robert Ife , Colin Leach , John Liddle , Ivan Pinto , Stephen Smith , Steven Stanway
IPC分类号: C07D215/22 , A61K31/47 , A61K31/4709 , A61K31/5377 , A61P3/10 , A61P9/10 , A61P9/12 , A61P17/06 , A61P19/02 , A61P29/00 , A61P43/00 , C07D215/06 , C07D215/233 , C07D401/12 , C07D413/12 , C07D471/02 , A61K31/517 , A61K31/519
CPC分类号: C07D215/233
摘要: Compounds of the formula (I) are inhibitors of the enzyme Lp-PLA2? and are of use in therapy, in particular for treating atherosclerosis.
摘要翻译: 式(I)的化合物是酶抑制剂Lp-PLA
2? 并且用于治疗,特别是用于治疗动脉粥样硬化。 -
4.Pyrimidinone Derivatives and Their Use in the Treatment of Atherosclerosis 失效
标题翻译: 嘧啶酮衍生物及其在治疗动脉粥样硬化中的应用公开(公告)号:US20060241126A1
公开(公告)日:2006-10-26
申请号:US11456129
申请日:2006-07-07
申请人: Richard Elliott , Deirdre Hickey , Robert Ife , Colin Leach , Ivan Pinto , Stephen Smith
发明人: Richard Elliott , Deirdre Hickey , Robert Ife , Colin Leach , Ivan Pinto , Stephen Smith
IPC分类号: A61K31/519 , C07D239/70
CPC分类号: C07D239/36 , C07D239/70 , C07D239/91 , C07D401/12 , C07D403/12 , C07D409/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要: Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
摘要翻译: 式(I)化合物:是Lp-PLA 2酶的抑制剂,可用于治疗,特别是用于治疗动脉粥样硬化。
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5.Pyridone, pyridazone and triazone derivatives as lp-pla2 inhibitors 审中-公开
标题翻译: 吡啶酮,哒嗪酮和三嗪衍生物作为lp-pla2抑制剂公开(公告)号:US20050020832A1
公开(公告)日:2005-01-27
申请号:US10495022
申请日:2002-11-08
申请人: Stephen Fell , Deirdre Hickey , Colin Leach , John Liddle , Ivan Pinto , Stephen Smith
发明人: Stephen Fell , Deirdre Hickey , Colin Leach , John Liddle , Ivan Pinto , Stephen Smith
IPC分类号: A61K31/501 , A61P9/10 , A61P17/06 , A61P29/00 , C07D401/12 , C07D401/14 , C07D237/02 , C07D241/02
CPC分类号: C07D401/12 , C07D401/14
摘要: Compounds of the formula (I) are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
摘要翻译: 式(I)的化合物是Lp-PLA2酶的抑制剂,并且在治疗中尤其用于治疗动脉粥样硬化。
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公开(公告)号:US20050033052A1
公开(公告)日:2005-02-10
申请号:US10495025
申请日:2002-11-08
申请人: Colin Leach , Ivan Pinto , Stephen Smith , Steven Stanway
发明人: Colin Leach , Ivan Pinto , Stephen Smith , Steven Stanway
IPC分类号: A61K31/519 , A61P3/10 , A61P9/10 , A61P9/12 , C07D495/04 , C07D213/69 , C07D239/02
CPC分类号: C07D495/04
摘要: Pyrimidone and pyridone compounds of the formula: are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
摘要翻译: 下式的嘧啶酮和吡啶酮化合物是Lp-PLA2酶的抑制剂,可用于治疗,特别是用于治疗动脉粥样硬化。
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公开(公告)号:US20070155762A1
公开(公告)日:2007-07-05
申请号:US11561035
申请日:2006-11-17
申请人: Colin Leach , Stephen Smith , Steven Stanway
发明人: Colin Leach , Stephen Smith , Steven Stanway
IPC分类号: A61K31/513 , A61K31/401 , A61K31/366 , A61K31/22
CPC分类号: C07D239/56 , C07D239/60 , C07D239/70 , C07D239/95 , C07D401/12 , C07D403/12 , C07D495/04
摘要: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.
摘要翻译: 式(I)的嘧啶酮化合物:是Lp-PLA 2酶的抑制剂,可用于治疗动脉粥样硬化。
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8.N-substituted pyridinone and pyrimidinone derivatives for use as lp-pla2 inhibitors in the treatment of artherosclerosis 审中-公开
标题翻译: N-取代的吡啶酮和嘧啶酮衍生物用作治疗动脉粥样硬化的lp-pla2抑制剂公开(公告)号:US20050245552A1
公开(公告)日:2005-11-03
申请号:US10510467
申请日:2003-04-10
申请人: Colin Leach , Stephen Smith
发明人: Colin Leach , Stephen Smith
IPC分类号: A61K31/4545 , A61K31/4709 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/12 , A61P17/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P31/04 , A61P43/00 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/513 , A61K31/4415 , A61K31/4439 , C07D211/72 , C07D43/02
CPC分类号: C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要: Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis. In Formula I R1, R2, R3, R4, R5, R6, X and Y.
摘要翻译: 式(I)化合物:是Lp-PLA 2酶的抑制剂,可用于治疗,特别是用于治疗动脉粥样硬化。 在式IR 1中,R 2,R 3,R 4,R 5,..., R 6,X和Y。
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公开(公告)号:US20220224993A2
公开(公告)日:2022-07-14
申请号:US17114186
申请日:2020-12-07
申请人: Brick Eksten , Stephen Smith , Yuval Fisher , Steven Reynolds
发明人: Brick Eksten , Stephen Smith , Yuval Fisher , Steven Reynolds
IPC分类号: H04N21/845 , H04N21/262 , H04N21/2343 , H04N21/24 , H04L29/06 , H04N21/458 , H04N21/488
摘要: A system for producing fragmented video content is provided. The system includes a processing device, a non-transitory data store, and a memory storage device having at least a Manifest Processing Service (MPS) unit stored therein. The MPS unit is configured to generate at least one master manifest and store the master manifest in the non-transitory data store, the master manifest comprising a timing reference for a video fragment of the fragmented video content, wherein the timing reference indicates a temporal boundary of processing for the video fragment.
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10.Human antibodies that bind the P40 subunit of human IL-12 and methods for using the same 有权
标题翻译: 结合人IL-12的P40亚基的人抗体及其使用方法公开(公告)号:US09035030B2
公开(公告)日:2015-05-19
申请号:US13401559
申请日:2012-02-21
申请人: Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
发明人: Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
IPC分类号: C07K16/24 , C12P21/08 , A61K39/395 , A61K39/00 , C07K16/18 , C07K16/00 , C07K14/54 , A61K38/20
CPC分类号: C07K16/244 , A61K9/0019 , A61K38/208 , A61K39/00 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2039/505 , C07K14/5434 , C07K16/00 , C07K16/18 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/94 , Y10S514/863 , Y10S514/885 , Y10S514/886
摘要: Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
摘要翻译: 公开了特异性结合人白细胞介素-12(hIL-12)的人抗体,优选重组人抗体。 优选的抗体对hIL-12具有高亲和力,并在体外和体内中和hIL-12活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性,例如在患有hIL-12活性有害的病症的人类受试者中。 用于表达本发明的重组人抗体的核酸,载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。
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