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公开(公告)号：US20230416205A1
公开(公告)日：2023-12-28
申请号：US18037999
申请日：2021-11-19
发明人： Alex L. Bagdasarian , Cyril Bucher , Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Brian M. Fox , Cheng Hu , Benjamin J. Huffman , Katrina W. Lexa , Lizanne G. Nilewski , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D217/24 , C07D401/12 , C07D471/04 , C07D401/14 , C07D493/08 , C07D491/107 , C07D413/08 , C07D405/12 , C07D417/12 , C07D487/04 , C07D417/14 , C07D498/04 , C07D405/14 , C07D495/04
CPC分类号： C07D217/24 , C07D401/12 , C07D471/04 , C07D401/14 , C07D493/08 , C07D491/107 , C07D413/08 , C07D405/12 , C07D417/12 , C07D487/04 , C07D417/14 , C07D498/04 , C07D405/14 , C07D495/04
摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
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公开(公告)号：US11643446B2
公开(公告)日：2023-05-09
申请号：US17697771
申请日：2022-03-17
发明人： Gerald Maxwell Cherf , Gunasekaran Kannan , Katrina W. Lexa , Ray L. Y. Low , Rachel Prorok , Ankita Srivastava
IPC分类号： C07K14/47 , A61P25/28 , C07K14/475 , A61K38/00
CPC分类号： C07K14/47 , A61P25/28 , C07K14/475 , A61K38/00 , C07K2319/30
摘要： Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
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公开(公告)号：US20220411433A1
公开(公告)日：2022-12-29
申请号：US17531039
申请日：2021-11-19
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Christopher R.H. Hale , Katrina W. Lexa , Maksim Osipov , Travis Remarchuk , Zachary K. Sweeney
IPC分类号： C07D491/048 , C07C235/22 , C07D207/27 , C07D233/36 , C07D233/42 , C07D233/61 , C07D233/64 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07D263/38 , C07D263/56 , C07D271/06 , C07D271/10 , C07D291/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
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公开(公告)号：US20210188925A1
公开(公告)日：2021-06-24
申请号：US17159038
申请日：2021-01-26
发明人： Gerald Maxwell Cherf , Gunasekaran Kannan , Katrina W. Lexa , Ray L.Y. Low , Rachel Prorok , Ankita Srivastava
摘要： Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
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公开(公告)号：US20240140919A1
公开(公告)日：2024-05-02
申请号：US18526983
申请日：2023-12-01
发明人： Robert A. Craig II, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Katrina W. Lexa , Maksim Osipov , Zachary K. Sweeney , Arun Tottumkara
IPC分类号： C07D271/07 , C07C235/22 , C07C255/46 , C07D205/04 , C07D205/12 , C07D209/52 , C07D211/58 , C07D221/20 , C07D233/32 , C07D401/04 , C07D413/04
CPC分类号： C07D271/07 , C07C235/22 , C07C255/46 , C07D205/04 , C07D205/12 , C07D209/52 , C07D211/58 , C07D221/20 , C07D233/32 , C07D401/04 , C07D413/04
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators of formula A, or a pharmaceutically acceptable salt, stereoisomer, or mixture of stereoisomers thereof and methods of making and using thereof.
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公开(公告)号：US20220220172A1
公开(公告)日：2022-07-14
申请号：US17698456
申请日：2022-03-18
发明人： Gerald Maxwell Cherf , Gunasekaran Kannan , Katrina W. Lexa , Ray L.Y. Low , Rachel Prorok , Ankita Srivastava
IPC分类号： C07K14/475 , A61P25/28
摘要： Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
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公开(公告)号：US20220177456A1
公开(公告)日：2022-06-09
申请号：US17436297
申请日：2020-03-06
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Katrina W. Lexa , Maksim Osipov , Zachary K. Sweeney , Arun Thottumkara
IPC分类号： C07D405/06 , C07D309/14 , C07D405/12 , C07D471/04 , C07D405/04
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.
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公开(公告)号：US20230265137A1
公开(公告)日：2023-08-24
申请号：US18189413
申请日：2023-03-24
发明人： Gerald Maxwell Cherf , Gunasekaran Kannan , Katrina W. Lexa , Ray L. Y. Low , Rachel Prorok , Ankita Srivastava
IPC分类号： C07K14/47 , A61P25/28 , C07K14/475
CPC分类号： C07K14/47 , A61P25/28 , C07K14/475 , C07K2319/30 , A61K38/00
摘要： Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
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公开(公告)号：US20220213155A1
公开(公告)日：2022-07-07
申请号：US17697771
申请日：2022-03-17
发明人： Gerald Maxwell Cherf , Gunasekaran Kannan , Katrina W. Lexa , Ray L.Y. Low , Rachel Prorok , Ankita Srivastava
IPC分类号： C07K14/475 , A61P25/28
摘要： Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
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公开(公告)号：US11236100B2
公开(公告)日：2022-02-01
申请号：US16637718
申请日：2018-08-08
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Christopher R. H. Hale , Katrina W. Lexa , Maksim Osipov , Travis Remarchuk , Zachary K. Sweeney
IPC分类号： C07D491/048 , C07C235/22 , C07C233/05 , C07C217/52 , C07C211/38 , C07D207/27 , C07D233/36 , C07D233/42 , C07D233/61 , C07D233/64 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07D263/38 , C07D263/56 , C07D271/06 , C07D271/10 , C07D291/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
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