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公开(公告)号：US5378604A
公开(公告)日：1995-01-03
申请号：US3367
申请日：1993-01-12
CPC分类号： C12Q1/689
摘要： This invention relates to compositions of oligonucleotide probes for use in the detection of bacteria associated with medical disorders of the human mouth, wherein said probes consist essentially of a segment of nucleic acid capable of selectively hybridizing under hybridizing conditions, to the 16S or 23S ribosomal RNA [rRNA] of said bacteria. Methods for detection, as well as diagnostic kits for the assay of these bacterium, are also disclosed.
摘要翻译： 本发明涉及用于检测与人口的医学病症相关的细菌的寡核苷酸探针的组合物，其中所述探针基本上由能够在杂交条件下选择性杂交的核酸片段与16S或23S核糖体RNA 所述细菌的[rRNA]。 还公开了检测方法以及用于这些细菌测定的诊断试剂盒。
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公开(公告)号：US5212059A
公开(公告)日：1993-05-18
申请号：US571563
申请日：1990-08-29
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689
摘要： This invention relates to compositions of oligonucleotide probes for use in the detection of bacteria associated with medical disorders of the human mouth, wherein said probes consist essentially of a segment of nucleic acid capable of selectively hybridizing under hybridizing conditions, to the 16S or 23S ribosomal RNA [rRNA] of said bacteria. Methods for detection, as well as diagnostic kits for the assay of these bacterium, are also disclosed.
摘要翻译： PCT No.PCT / US89 / 00072 Sec。 371日期1990年8月29日第 102（e）1990年8月29日的PCT日期1989年1月9日提交PCT本发明涉及用于检测与人口的医学病症相关的细菌的寡核苷酸探针的组合物，其中所述探针基本上由 的能够在杂交条件下选择性杂交的核酸与所述细菌的16S或23S核糖体RNA [rRNA]。 还公开了检测方法以及用于这些细菌测定的诊断试剂盒。
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公开(公告)号：US5334501A
公开(公告)日：1994-08-02
申请号：US41804
申请日：1993-04-01
CPC分类号： C12Q1/6888 , C12Q1/689
摘要： This invention provides for a method of quantifying bacteria using a bacterial specific nucleic acid probe which is complementary to a unique and highly conserved region of the 16S ribosomal RNA (rRNA) of bacteria. This probe permits the rapid detection of 16S rRNA in a sample and by comparison with known standards, one can estimate the total bacterial count in the sample. The method is accurate and reproducible and conducted at temperatures of between about 120.degree. to about 40.degree. C.
摘要翻译： 本发明提供了使用与细菌的16S核糖体RNA（rRNA）的独特且高度保守的区域互补的细菌特异性核酸探针来定量细菌的方法。 该探针允许快速检测样品中的16S rRNA，并与已知标准进行比较，可以估计样品中的总细菌数。 该方法是精确和可重复的，并且在约120℃至约40℃的温度下进行。
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4.发明授权S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy 失效代谢途径的S-腺苷甲硫氨酸调节及其在诊断和治疗中的应用公开(公告)号：US06596701B1
公开(公告)日：2003-07-22
申请号：US08930128
申请日：1998-03-16
IPC分类号： A01N4304
CPC分类号： A61K31/7076 , A61K31/198 , A61K31/4188 , A61K31/455 , A61K38/1709 , A61K45/06 , G01N33/6893
摘要： A new paradigm of disease centers around the metabolic pathways of S-adenosyl-L-methionine (SAM), the intermediates of these pathways and other metabolic pathways influenced by the SAM pathways. Methods are provided to analyze and modulate SAM pathways associated with a disease or condition. Such methods permit identification and utilization of diagnostic and therapeutic protocols and agents for such disease states and conditions.
摘要翻译： 疾病的新范例围绕S-腺苷-L-甲硫氨酸（SAM）的代谢途径，这些途径的中间体和其他由SAM途径影响的代谢途径。 提供了用于分析和调节与疾病或病症相关的SAM途径的方法。 这样的方法允许鉴定和利用诊断和治疗方案和药剂用于这种疾病状态和状况。
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5.发明授权
公开(公告)号：US4886741A
公开(公告)日：1989-12-12
申请号：US130709
申请日：1987-12-09
申请人： Dennis E. Schwartz
发明人： Dennis E. Schwartz
CPC分类号： C12Q1/6841 , C12Q1/6832 , C12Q1/708 , Y10S435/81
摘要： This invention relates to methods for using volume exclusion agents to enhance in situ hybridization rates between short oligonucleotide probes and their target polynucleotides where the cells containing the target polynucleotides are adhered onto a glass substrate. In one aspect, the invention specifically relates to the use of volume exclusion agents to facilitate assay and diagnostic procedures for the detection of a virus, such as human papillomavirus (HPV). In addition, diagnostic kits embracing the above methods are described herein.
摘要翻译： 本发明涉及使用体积排阻剂来增强短寡核苷酸探针与其靶多核苷酸之间的原位杂交速率的方法，其中含有靶多核苷酸的细胞粘附到玻璃基底上。 在一个方面，本发明具体涉及体积排阻剂用于检测病毒如人乳头状瘤病毒（HPV）的测定和诊断程序的用途。 此外，本文描述了包括上述方法的诊断试剂盒。
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6.发明授权
公开(公告)号：US6020139A
公开(公告)日：2000-02-01
申请号：US428963
申请日：1995-04-25
IPC分类号： A61K31/198 , A61K31/4188 , A61K31/455 , A61K38/17 , A61K45/06 , G01N33/53 , A01N37/30 , C12N9/08
CPC分类号： A61K31/7076 , A61K31/198 , A61K31/4188 , A61K31/455 , A61K38/1709 , A61K45/06
摘要： A new paradigm of disease centers around the metabolic pathways of S-adenosyl-L-methionine (SAM), the intermediates of these pathways and other metabolic pathways influenced by the SAM pathways. Methods are provided to analyze and modulate SAM pathways associated with a disease or condition. Such methods permit identification and utilization of diagnostic and therapeutic protocols and agents for such disease states and conditions.
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公开(公告)号：US4749647A
公开(公告)日：1988-06-07
申请号：US623838
申请日：1984-06-22
IPC分类号： C12Q1/68 , C12Q1/70 , G01N33/537
CPC分类号： G01N33/5375 , C12Q1/68 , C12Q1/682 , C12Q1/701 , Y10S436/827 , Y10S525/904
摘要： Methods and compounds are disclosed for determining the presence, amount of, or association between substances of interest in samples suspected of containing same. The methods are based on the polymerization-induced separation of specifically-bound, reporter-labeled recognition reactants from free, reporter-labeled recognition reactants. The methods described are applicable to any substance for which suitable recognition reactants exist or can be made and are not limited by considerations such as chemical composition or molecular size.
摘要翻译： 公开了用于确定怀疑含有其的样品中感兴趣的物质的存在，量或关联的方法和化合物。 该方法基于聚合诱导的分离来自游离的报道分子标记的识别反应物的特异结合的报道分子标记的识别反应物。 所描述的方法适用于存在或可以制备合适的识别反应物的任何物质，并且不受诸如化学组成或分子大小等考虑的限制。
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公开(公告)号：US5872104A
公开(公告)日：1999-02-16
申请号：US364246
申请日：1994-12-27
CPC分类号： A61K45/06 , Y10S977/80 , Y10S977/801
摘要： Disclosed are novel methods, combinations of agents and kits for use in killing, or inhibiting the growth of, microorganisms. Enhanced antimicrobial action is provided by using a methylation inhibitor, as exemplified by using an agent that inhibits methylation or maturation of bacterial RNA in combination with, e.g., a macrolide lincosamide streptogramin B (MLS) antibiotic. The methods and compositions described may be employed to reduce the resistance of susceptible microorganisms to antimicrobial agents and thus to treat animals or patients with infections.
摘要翻译： 公开了用于杀死或抑制微生物生长的新方法，试剂和试剂盒的组合。 通过使用甲基化抑制剂提供增强的抗微生物作用，例如通过使用抑制细菌RNA的甲基化或成熟的药剂与例如大环内酯氯胺素链霉素B（MLS）抗生素的组合来实施。 可以使用所描述的方法和组合来降低敏感微生物对抗微生物剂的抵抗力，从而治疗感染的动物或患者。
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