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公开(公告)号：US5922573A
公开(公告)日：1999-07-13
申请号：US809185
申请日：1997-04-15
申请人： Diana Boraschi , Paola Bossu , Paolo Ruggiero , Giovanni Macchia , Aldo Tagliabue , Francesco Frigerio , Renata Grifantini , Gianni Frascotti , Guido Grandi
发明人： Diana Boraschi , Paola Bossu , Paolo Ruggiero , Giovanni Macchia , Aldo Tagliabue , Francesco Frigerio , Renata Grifantini , Gianni Frascotti , Guido Grandi
CPC分类号： C07K14/54 , A61K38/00 , Y10S930/141
摘要： DNA molecules that code for IL-1 antagonists with improved biological activity arc described. DNA molecules coding for improved IL-1 antagonists inserted into expression vectors and host cells transformed with the said vectors containing the DNA coding for improved IL-1 antagonists and a method for the production of improved IL-1 antagonists in essentially pure form are also described. Preparations that can be injected or can be administered by some other route, consisting of a pharmaceutical preparation of the said mutants, are particularly useful as drugs in the field of therapy.
摘要翻译： PCT No.PCT / EP95 / 03708 Sec。 371日期1997年04月15日 102（e）1997年4月15日PCT PCT 1995年9月20日PCT公布。 公开号WO96 / 09323 描述1996年3月28日描述了编码具有改善的生物活性的IL-1拮抗剂的DNA分子。 还描述了编码插入到表达载体中的改良的IL-1拮抗剂和用含有编码改进的IL-1拮抗剂的DNA的所述载体转化的宿主细胞的DNA分子和用于生产基本上纯的形式的改良的IL-1拮抗剂的方法 。 可以通过由所述突变体的药物制剂组成的其它途径注射或可以给药的制剂在治疗领域中特别有用。
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公开(公告)号：US6077706A
公开(公告)日：2000-06-20
申请号：US470260
申请日：1995-06-06
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/106 , A61K39/39 , A61K48/00 , A61P1/04 , A61P31/04 , A61P35/00 , C07H21/00 , C07H21/04 , C07K7/06 , C07K14/195 , C07K14/205 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/80 , C12N15/09 , C12N15/31 , C12N15/62 , C12N15/66 , C12N15/74 , C12P19/34 , C12P21/02 , C12Q1/68 , C12R1/01 , C12R1/19 , G01N33/569 , C12N1/20
CPC分类号： C07K14/195 , C07K14/205 , C12Q1/689 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/35 , C07K2319/40
摘要： Helicobacter pylori known to cause or be a cofactor in type B gastritis, peptic ulcers, and gastric tumors. In both developed and developing countries, a high percentage of people are infected with this bacterium. The present invention relates generally to certain H. pylori proteins, to the genes which express these proteins, and to the use of these proteins for diagnostic and vaccine applications. Specifically, molecular cloning, nucleotide, and amino add sequences for the H. pylori cytotoxin (CT), the "Cytotoxin Associated Immunodominant" (CAI) antigen, and the heat shock protein (hsp60) are described herein.
摘要翻译： 幽门螺杆菌已知会导致或成为B型胃炎，消化性溃疡和胃肿瘤中的辅因子。 在发达国家和发展中国家，很高比例的人感染了这种细菌。 本发明一般涉及某些幽门螺杆菌蛋白质，表达这些蛋白质的基因，以及这些蛋白质用于诊断和疫苗应用的用途。 具体地，本文描述了幽门螺杆菌细胞毒素（CT），“细胞毒素相关免疫显性”（CAI）抗原和热休克蛋白（hsp60）的分子克隆，核苷酸和氨基酸序列。
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公开(公告)号：US6090611A
公开(公告)日：2000-07-18
申请号：US471491
申请日：1995-06-06
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/106 , A61P1/04 , A61P31/04 , C07K14/195 , C07K14/205 , C12N1/21 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689 , C07K14/205 , A61K38/00 , A61K39/00 , C07K2319/00 , Y10S435/975
摘要： A cytotoxin associated immunodominant antigen and the nucleic acid encoding the antigen from Helicobacter pylori are described. This antigen was identified from the cytotoxin positive CCUG 17874 Helicobacter pylori strain, and both the antigen and the DNA encoding it have been sequenced. The antigen is a hydrophilic, surface-exposed protein having a molecular weight of 120-132 kDa. The nucleic acid encoding the antigen may be incorporated into a vector for transformation of host cells for expression of the antigen. Both the DNA and the antigen can be used in assays for detection of disease or infection by Helicobacter pylori, and may find use in treating and preventing infection by Helicobacter pylori and the diseases associated with such infection.
摘要翻译： 描述了细胞毒素相关免疫显性抗原和编码幽门螺旋杆菌抗原的核酸。 从细胞毒素阳性CCUG 17874幽门螺杆菌菌株鉴定出该抗原，并且对抗原和编码它的DNA进行了测序。 抗原是亲水性，表面暴露的蛋白质，其分子量为120-132kDa。 编码抗原的核酸可以并入用于转化宿主细胞用于表达抗原的载体中。 DNA和抗原都可用于检测幽门螺杆菌疾病或感染的检测中，可用于治疗和预防幽门螺杆菌感染以及与此类感染有关的疾病。
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公开(公告)号：US20070243204A1
公开(公告)日：2007-10-18
申请号：US11580632
申请日：2006-10-12
CPC分类号： A61K39/105 , A61K39/00 , C07K14/195 , C07K14/205 , Y10S530/825
摘要： This invention provides polypeptides of Helicobacter Pylori cytotoxin associated immunodominant (CAI) antigen. The invention also provides prophylactic and therapeutic vaccines comprising polypeptides of Helicobacter pylori CAI antigen, and methods for preparation. The invention also provides methods of treatment of Helicobacter pylori infection using these vaccines.
摘要翻译： 本发明提供幽门螺杆菌细胞毒素相关免疫显性（CAI）抗原的多肽。 本发明还提供包含幽门螺杆菌CAI抗原多肽的预防和治疗疫苗及其制备方法。 本发明还提供使用这些疫苗治疗幽门螺杆菌感染的方法。
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公开(公告)号：US6130059A
公开(公告)日：2000-10-10
申请号：US466662
申请日：1995-06-06
IPC分类号： A61P31/04 , C12N1/21 , C12Q1/68 , A61K39/106 , C07H21/04 , C07K14/205
CPC分类号： C12Q1/689 , Y10S435/975
摘要： Helicobacter pylori is known to cause or be a cofactor in type B gastritis, peptic ulcers, and gastric tumors. In both developed and developing countries, a high percentage of people are infected with this bacterium. The present invention relates generally to certain H. pylori proteins, to the genes which express these proteins, and to the use of these proteins for diagnostic and vaccine applications. Specifically, molecular cloning, nucteotide, and amino acid sequences for the H. pylori cytotoxin (CT), the "Cytotoxin Associated Immunodominant" (CAI) antigen, and the heat shock protein (hsp60). are described herein.
摘要翻译： 已知幽门螺杆菌可引起或成为B型胃炎，消化性溃疡和胃肿瘤中的辅因子。 在发达国家和发展中国家，很高比例的人感染了这种细菌。 本发明一般涉及某些幽门螺杆菌蛋白质，表达这些蛋白质的基因，以及这些蛋白质用于诊断和疫苗应用的用途。 具体地，幽门螺杆菌细胞毒素（CT），“细胞毒素相关免疫显性”（CAI）抗原和热休克蛋白（hsp60）的分子克隆，核苷酸和氨基酸序列。 在此描述。
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公开(公告)号：US07700755B2
公开(公告)日：2010-04-20
申请号：US10615668
申请日：2003-07-08
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , C07K14/205 , C07K2319/00 , C07K2319/35 , C07K2319/40 , C12Q1/689
摘要： This invention provides polynucleotides encoding Helicobacter pylori cytotoxin associated immunodominant antigen. The polynucleotides can be used as probes to identify the presence of complementary target nucleotide sequences. The invention also provides kits and vectors containing the polynucleotides of the invention.
摘要翻译： 本发明提供编码幽门螺杆菌细胞毒素相关免疫显性抗原的多核苷酸。 多核苷酸可用作探针以鉴定互补靶核苷酸序列的存在。 本发明还提供了含有本发明的多核苷酸的试剂盒和载体。
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公开(公告)号：US07141244B1
公开(公告)日：2006-11-28
申请号：US09360685
申请日：1999-07-26
CPC分类号： A61K39/105 , A61K39/00 , C07K14/195 , C07K14/205 , Y10S530/825
摘要： This invention provides polypeptides of Helicobacter pylori cytotoxin associated immunodominant (CAI) antigen. The invention also provides prophylactic and therapeutic vaccines comprising polypeptides of Helicobacter pylori CAI antigen, and methods for their preparation. The invention also provides methods of treatment of Helicobactor pylori infection using these vaccines.
摘要翻译： 本发明提供幽门螺杆菌细胞毒素相关免疫显性（CAI）抗原的多肽。 本发明还提供包含幽门螺杆菌CAI抗原多肽的预防和治疗疫苗及其制备方法。 本发明还提供使用这些疫苗治疗幽门螺杆菌感染幽门螺杆菌感染的方法。
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公开(公告)号：US20050276819A1
公开(公告)日：2005-12-15
申请号：US10615668
申请日：2003-07-08
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/106 , A61K39/39 , A61K48/00 , A61P1/04 , A61P31/04 , A61P35/00 , C07H21/00 , C07H21/04 , C07K7/06 , C07K14/195 , C07K14/205 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/80 , C12N15/09 , C12N15/31 , C12N15/62 , C12N15/66 , C12N15/74 , C12P19/34 , C12P21/02 , C12Q1/68 , C12R1/01 , C12R1/19 , G01N33/569
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , C07K14/205 , C07K2319/00 , C07K2319/35 , C07K2319/40 , C12Q1/689
摘要： This invention provides polynucleotides encoding Helicobacter pylori cytotoxin associated immunodominant antigen. The polynucleotides can be used as probes to identify the presence of complementary target nucleotide sequences. The invention also provides kits and vectors containing the polynucleotides of the invention.
摘要翻译： 本发明提供编码幽门螺杆菌细胞毒素相关免疫显性抗原的多核苷酸。 多核苷酸可用作探针以鉴定互补靶核苷酸序列的存在。 本发明还提供了含有本发明的多核苷酸的试剂盒和载体。
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