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1.发明授权Method for determination of nucleated red blood cells and leukocytes in a whole blood sample in an automated hematology analyzer 有权在自动血液分析仪中测定全血样品中有核红细胞和白细胞的方法公开(公告)号：US07674622B2
公开(公告)日：2010-03-09
申请号：US11644318
申请日：2006-12-22
CPC分类号： G01N33/721 , G01N15/147 , G01N33/80 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G01N2015/1493 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25 , Y10T436/25125
摘要： A method for enumerating white blood cells and nucleated red blood cells. The steps of the method are as follows: (a) providing a lysed sample of whole blood; (b) introducing the lysed sample to a light-scattering multi-angle depolarizing flow cytometer; (c) removing depolarizing interference, e.g., lipid droplets and other measured particles; (d) differentiating nucleated red blood cells and noise from white blood cells in the absence of depolarizing interference; (e) differentiating nucleated red blood cells from noise in the absence of depolarizing interference and white blood cells; and (f) differentiating possible platelet clumps.
摘要翻译： 一种用于计数白细胞和有核红细胞的方法。 该方法的步骤如下：（a）提供全血的裂解样品; （b）将溶解的样品引入光散射多角度去极化流式细胞仪; （c）去除去极化干扰，例如脂滴和其它测量的颗粒; （d）在没有去极化干扰的情况下，区分有核红细胞和白细胞的噪声; （e）在没有去极化干扰和白细胞的情况下，将有核红细胞与噪声区分开来; 和（f）区分可能的血小板结块。
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2.发明申请Method for determination of nucleated red blood cells and leukocytes in a whole blood sample in an automated hematology analyzer 有权在自动血液分析仪中测定全血样品中有核红细胞和白细胞的方法公开(公告)号：US20080153170A1
公开(公告)日：2008-06-26
申请号：US11644318
申请日：2006-12-22
IPC分类号： G01N33/48
CPC分类号： G01N33/721 , G01N15/147 , G01N33/80 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G01N2015/1493 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25 , Y10T436/25125
摘要： A method for enumerating white blood cells and nucleated red blood cells. The method comprises the steps of: (b) providing a lysed sample of whole blood; (b) introducing the lysed sample to a light-scattering multi-angle depolarizing flow cytometer; (c) removing depolarizing interference, e.g., lipid droplets and other measured particles; (d) differentiating nucleated red blood cells and noise from white blood cells in the absence of depolarizing interference; (e) differentiating nucleated red blood cells from noise in the absence of depolarizing interference and white blood cells; and (f) differentiating possible platelet clumps.
摘要翻译： 一种用于计数白细胞和有核红细胞的方法。 该方法包括以下步骤：（b）提供全血的裂解样品; （b）将溶解的样品引入光散射多角度去极化流式细胞仪; （c）去除去极化干扰，例如脂滴和其它测量的颗粒; （d）在没有去极化干扰的情况下，区分有核红细胞和白细胞的噪声; （e）在没有去极化干扰和白细胞的情况下，将有核红细胞与噪声区分开来; 和（f）区分可能的血小板结块。
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公开(公告)号：US20110045525A1
公开(公告)日：2011-02-24
申请号：US12546552
申请日：2009-08-24
申请人： Martin Krockenberger , Richard B. Bordenkircher , Diana G. Garrett , John G. Glazier , James C. Bearden , Bodo Roemer , Giacomo Vacca
发明人： Martin Krockenberger , Richard B. Bordenkircher , Diana G. Garrett , John G. Glazier , James C. Bearden , Bodo Roemer , Giacomo Vacca
CPC分类号： G01N33/4915 , G01N15/1429 , G01N15/1459 , G01N33/492 , G01N2015/0069 , G01N2015/008 , G01N2015/1006 , G01N2015/1486 , G01N2015/1488 , Y10T436/101666 , Y10T436/2575
摘要： A hematology analyzer is provided. In certain embodiments, the hematology analyzer comprises: a) a flow cell; b) a light source for directing light to the flow cell; c) a plurality of detectors for detecting a plurality of optical characteristics of a blood cell passing through the flow cell; and d) a data analysis workstation programmed to: i. enumerate test blood cells passing through the flow cell; and ii. flag a blood sample as containing lysis-resistant red blood cells or fragile white blood cells.
摘要翻译： 提供血液分析仪。 在某些实施方案中，血液分析仪包括：a）流动池; b）用于将光引导到流动池的光源; c）多个检测器，用于检测通过流通池的血细胞的多个光学特性; 和d）数据分析工作站被编程为：i。 列举通过流动池的测试血液细胞; 和ii。 标记含有裂解抗性红细胞或脆弱白细胞的血液样品。
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公开(公告)号：US08911669B2
公开(公告)日：2014-12-16
申请号：US12546552
申请日：2009-08-24
申请人： Martin Krockenberger , Richard B. Bordenkircher , Diana G. Garrett , John G. Glazier , James C. Bearden , Bodo Roemer , Giacomo Vacca
发明人： Martin Krockenberger , Richard B. Bordenkircher , Diana G. Garrett , John G. Glazier , James C. Bearden , Bodo Roemer , Giacomo Vacca
CPC分类号： G01N33/4915 , G01N15/1429 , G01N15/1459 , G01N33/492 , G01N2015/0069 , G01N2015/008 , G01N2015/1006 , G01N2015/1486 , G01N2015/1488 , Y10T436/101666 , Y10T436/2575
摘要： A hematology analyzer is provided. In certain embodiments, the hematology analyzer comprises: a) a flow cell; b) a light source for directing light to the flow cell; c) a plurality of detectors for detecting a plurality of optical characteristics of a blood cell passing through the flow cell; and d) a data analysis workstation programmed to: i. enumerate test blood cells passing through the flow cell; and ii. flag a blood sample as containing lysis-resistant red blood cells or fragile white blood cells.
摘要翻译： 提供血液分析仪。 在某些实施方案中，血液分析仪包括：a）流动池; b）用于将光引导到流动池的光源; c）多个检测器，用于检测通过流通池的血细胞的多个光学特性; 和d）数据分析工作站被编程为：i。 列举通过流动池的测试血液细胞; 和ii。 标记含有裂解抗性红细胞或脆弱白细胞的血液样品。
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5.发明申请Method for determining volume and hemoglobin content of individual red blood cells 有权测定个体红细胞体积和血红蛋白含量的方法公开(公告)号：US20110178716A1
公开(公告)日：2011-07-21
申请号：US12657218
申请日：2010-01-15
IPC分类号： G06F19/00
CPC分类号： G01N15/06 , G01N15/0656 , G01N15/1459 , G01N15/147 , G01N33/4915 , G01N33/492 , G01N33/721 , G01N2015/0065 , G01N2015/0073 , G01N2015/0687 , G01N2015/0693 , G01N2333/805 , Y10T436/101666
摘要： Provided herein is a method for determining the volume or hemoglobin content of an individual red blood cell in a sample containing a population of red blood cells. The method may be performed on a hematology analyzer. Also provided are a hematology analyzer for performing the method and a computer-readable medium containing programming for performing the method.
摘要翻译： 本文提供了用于测定含有红细胞群体的样品中各个红细胞的体积或血红蛋白含量的方法。 该方法可以在血液分析仪上进行。 还提供了用于执行该方法的血液分析仪和包含用于执行该方法的程序的计算机可读介质。
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6.发明授权Method for determining volume and hemoglobin content of individual red blood cells 有权测定个体红细胞体积和血红蛋白含量的方法公开(公告)号：US08906308B2
公开(公告)日：2014-12-09
申请号：US12657218
申请日：2010-01-15
CPC分类号： G01N15/06 , G01N15/0656 , G01N15/1459 , G01N15/147 , G01N33/4915 , G01N33/492 , G01N33/721 , G01N2015/0065 , G01N2015/0073 , G01N2015/0687 , G01N2015/0693 , G01N2333/805 , Y10T436/101666
摘要： A method for determining the volume or hemoglobin content of an individual red blood cell in a sample containing a population of red blood cells. The method may be performed on a hematology analyzer. Also provided are a hematology analyzer for performing the method and a computer-readable medium containing programming for performing the method.
摘要翻译： 一种用于测定含有红细胞群的样品中各个红细胞的体积或血红蛋白含量的方法。 该方法可以在血液分析仪上进行。 还提供了用于执行该方法的血液分析仪和包含用于执行该方法的程序的计算机可读介质。
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