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公开(公告)号：US08911669B2
公开(公告)日：2014-12-16
申请号：US12546552
申请日：2009-08-24
申请人： Martin Krockenberger , Richard B. Bordenkircher , Diana G. Garrett , John G. Glazier , James C. Bearden , Bodo Roemer , Giacomo Vacca
发明人： Martin Krockenberger , Richard B. Bordenkircher , Diana G. Garrett , John G. Glazier , James C. Bearden , Bodo Roemer , Giacomo Vacca
CPC分类号： G01N33/4915 , G01N15/1429 , G01N15/1459 , G01N33/492 , G01N2015/0069 , G01N2015/008 , G01N2015/1006 , G01N2015/1486 , G01N2015/1488 , Y10T436/101666 , Y10T436/2575
摘要： A hematology analyzer is provided. In certain embodiments, the hematology analyzer comprises: a) a flow cell; b) a light source for directing light to the flow cell; c) a plurality of detectors for detecting a plurality of optical characteristics of a blood cell passing through the flow cell; and d) a data analysis workstation programmed to: i. enumerate test blood cells passing through the flow cell; and ii. flag a blood sample as containing lysis-resistant red blood cells or fragile white blood cells.
摘要翻译： 提供血液分析仪。 在某些实施方案中，血液分析仪包括：a）流动池; b）用于将光引导到流动池的光源; c）多个检测器，用于检测通过流通池的血细胞的多个光学特性; 和d）数据分析工作站被编程为：i。 列举通过流动池的测试血液细胞; 和ii。 标记含有裂解抗性红细胞或脆弱白细胞的血液样品。
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公开(公告)号：US20110045525A1
公开(公告)日：2011-02-24
申请号：US12546552
申请日：2009-08-24
申请人： Martin Krockenberger , Richard B. Bordenkircher , Diana G. Garrett , John G. Glazier , James C. Bearden , Bodo Roemer , Giacomo Vacca
发明人： Martin Krockenberger , Richard B. Bordenkircher , Diana G. Garrett , John G. Glazier , James C. Bearden , Bodo Roemer , Giacomo Vacca
CPC分类号： G01N33/4915 , G01N15/1429 , G01N15/1459 , G01N33/492 , G01N2015/0069 , G01N2015/008 , G01N2015/1006 , G01N2015/1486 , G01N2015/1488 , Y10T436/101666 , Y10T436/2575
摘要： A hematology analyzer is provided. In certain embodiments, the hematology analyzer comprises: a) a flow cell; b) a light source for directing light to the flow cell; c) a plurality of detectors for detecting a plurality of optical characteristics of a blood cell passing through the flow cell; and d) a data analysis workstation programmed to: i. enumerate test blood cells passing through the flow cell; and ii. flag a blood sample as containing lysis-resistant red blood cells or fragile white blood cells.
摘要翻译： 提供血液分析仪。 在某些实施方案中，血液分析仪包括：a）流动池; b）用于将光引导到流动池的光源; c）多个检测器，用于检测通过流通池的血细胞的多个光学特性; 和d）数据分析工作站被编程为：i。 列举通过流动池的测试血液细胞; 和ii。 标记含有裂解抗性红细胞或脆弱白细胞的血液样品。
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3.发明授权Method for discriminating red blood cells from white blood cells by using forward scattering from a laser in an automated hematology analyzer 有权在自动血液分析仪中使用来自激光的前向散射来鉴别红细胞与白细胞的方法公开(公告)号：US08906309B2
公开(公告)日：2014-12-09
申请号：US12767611
申请日：2010-04-26
申请人： Martin Krockenberger , Jiong Wu , Bodo Roemer , Giacomo Vacca
发明人： Martin Krockenberger , Jiong Wu , Bodo Roemer , Giacomo Vacca
CPC分类号： G01N15/1404 , G01N15/00 , G01N15/1429 , G01N15/1459 , G01N21/53 , G01N33/49 , G01N33/4915 , G01N33/492 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G01N2015/1486 , G01N2800/22 , Y10T436/101666
摘要： A method for identifying, analyzing, and quantifying the cellular components of whole blood by use of an automated hematology analyzer and the detection of the light scattered, absorbed, and fluorescently emitted by each cell. More particularly, the aforementioned method involves identifying, analyzing, and quantifying the cellular components of whole blood by use of a light source having a wavelength ranging from about 400 nm to about 450 nm and multiple in-flow optical measurements and staining without the need for lysing red blood cells.
摘要翻译： 一种通过使用自动血液分析仪来鉴定，分析和定量全血细胞成分的方法，以及每个细胞散射，吸收和荧光发射的光的检测。 更具体地，上述方法包括通过使用波长范围为约400nm至约450nm的光源和多次流入光学测量和染色来识别，分析和定量全血的细胞组分，并且不需要 裂解红细胞。
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4.发明申请METHOD FOR DISCRIMINATING RED BLOOD CELLS FROM WHITE BLOOD CELLS BY USING FORWARD SCATTERING FROM A LASER IN AN AUTOMATED HEMATOLOGY ANALYZER 有权用于通过使用来自自动化学分析仪中的激光的前向散射来鉴别来自白血球细胞的红细胞的方法公开(公告)号：US20100273168A1
公开(公告)日：2010-10-28
申请号：US12767611
申请日：2010-04-26
申请人： Martin Krockenberger , Jiong Wu , Bodo Roemer , Giacomo Vacca
发明人： Martin Krockenberger , Jiong Wu , Bodo Roemer , Giacomo Vacca
CPC分类号： G01N15/1404 , G01N15/00 , G01N15/1429 , G01N15/1459 , G01N21/53 , G01N33/49 , G01N33/4915 , G01N33/492 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G01N2015/1486 , G01N2800/22 , Y10T436/101666
摘要： A method for identifying, analyzing, and quantifying the cellular components of whole blood by means of an automated hematology analyzer and the detection of the light scattered, absorbed, and fluorescently emitted by each cell. More particularly, the aforementioned method involves identifying, analyzing, and quantifying the cellular components of whole blood by means of a light source having a wavelength ranging from about 400 nm to about 450 nm and multiple in-flow optical measurements and staining without the need for lysing red blood cells.
摘要翻译： 一种通过自动血液分析仪识别，分析和定量全血细胞成分的方法，以及每个细胞散射，吸收和荧光发射的光的检测。 更具体地，上述方法包括通过具有波长范围为约400nm至约450nm的光源和多次流入光学测量和染色来鉴定，分析和定量全血的细胞组分，并且不需要 裂解红细胞。
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5.发明授权Method for determination of nucleated red blood cells and leukocytes in a whole blood sample in an automated hematology analyzer 有权在自动血液分析仪中测定全血样品中有核红细胞和白细胞的方法公开(公告)号：US07674622B2
公开(公告)日：2010-03-09
申请号：US11644318
申请日：2006-12-22
CPC分类号： G01N33/721 , G01N15/147 , G01N33/80 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G01N2015/1493 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25 , Y10T436/25125
摘要： A method for enumerating white blood cells and nucleated red blood cells. The steps of the method are as follows: (a) providing a lysed sample of whole blood; (b) introducing the lysed sample to a light-scattering multi-angle depolarizing flow cytometer; (c) removing depolarizing interference, e.g., lipid droplets and other measured particles; (d) differentiating nucleated red blood cells and noise from white blood cells in the absence of depolarizing interference; (e) differentiating nucleated red blood cells from noise in the absence of depolarizing interference and white blood cells; and (f) differentiating possible platelet clumps.
摘要翻译： 一种用于计数白细胞和有核红细胞的方法。 该方法的步骤如下：（a）提供全血的裂解样品; （b）将溶解的样品引入光散射多角度去极化流式细胞仪; （c）去除去极化干扰，例如脂滴和其它测量的颗粒; （d）在没有去极化干扰的情况下，区分有核红细胞和白细胞的噪声; （e）在没有去极化干扰和白细胞的情况下，将有核红细胞与噪声区分开来; 和（f）区分可能的血小板结块。
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6.发明申请Method for determination of nucleated red blood cells and leukocytes in a whole blood sample in an automated hematology analyzer 有权在自动血液分析仪中测定全血样品中有核红细胞和白细胞的方法公开(公告)号：US20080153170A1
公开(公告)日：2008-06-26
申请号：US11644318
申请日：2006-12-22
IPC分类号： G01N33/48
CPC分类号： G01N33/721 , G01N15/147 , G01N33/80 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G01N2015/1493 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25 , Y10T436/25125
摘要： A method for enumerating white blood cells and nucleated red blood cells. The method comprises the steps of: (b) providing a lysed sample of whole blood; (b) introducing the lysed sample to a light-scattering multi-angle depolarizing flow cytometer; (c) removing depolarizing interference, e.g., lipid droplets and other measured particles; (d) differentiating nucleated red blood cells and noise from white blood cells in the absence of depolarizing interference; (e) differentiating nucleated red blood cells from noise in the absence of depolarizing interference and white blood cells; and (f) differentiating possible platelet clumps.
摘要翻译： 一种用于计数白细胞和有核红细胞的方法。 该方法包括以下步骤：（b）提供全血的裂解样品; （b）将溶解的样品引入光散射多角度去极化流式细胞仪; （c）去除去极化干扰，例如脂滴和其它测量的颗粒; （d）在没有去极化干扰的情况下，区分有核红细胞和白细胞的噪声; （e）在没有去极化干扰和白细胞的情况下，将有核红细胞与噪声区分开来; 和（f）区分可能的血小板结块。
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