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1.Preparation of salts of 4-[4-[(1R)-[4-(trifluoromethyl)phenyl]-2-methoxyethyl]-(3S)-methyl-1-piperazinyl]-4-methyl-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl] 失效
标题翻译: 制备4- [4 - [(1R) - [4-(三氟甲基)苯基] -2-甲氧基乙基] - (3S) - 甲基-1-哌嗪基] -4-甲基-1 - [(4,6 - 二甲基-5-嘧啶基)羰基]公开(公告)号:US06943251B2
公开(公告)日:2005-09-13
申请号:US10304674
申请日:2002-11-26
申请人: Dinesh Gala , Andrew J. Goodman , Gary Lee , Hongbiao Liao , Martin L. Schwartz , Suhan Tang , David Js Tsai , Wenxue Wu
发明人: Dinesh Gala , Andrew J. Goodman , Gary Lee , Hongbiao Liao , Martin L. Schwartz , Suhan Tang , David Js Tsai , Wenxue Wu
IPC分类号: C07D401/14 , A61K31/095 , A61K31/19 , A61K31/194 , A61K31/506 , A61P1/04 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D401/06
CPC分类号: C07D401/06
摘要: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.
摘要翻译: 在一个实施方案中,本发明公开了通过创造性地选择溶剂介质来直接制备酸性盐与碱性化合物的不等比例的旋转异构体的方法。 该方法特别可用于制备具有期望优势的药学上有用的盐的特定旋转异构体。
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公开(公告)号:US07534884B2
公开(公告)日:2009-05-19
申请号:US11093560
申请日:2005-03-30
申请人: Dinesh Gala , Andrew J. Goodman , Gary Lee , Hongbiao Liao , Martin L. Schwartz , Suhan Tang , David J. S. Tsai , Wenxue Wu
发明人: Dinesh Gala , Andrew J. Goodman , Gary Lee , Hongbiao Liao , Martin L. Schwartz , Suhan Tang , David J. S. Tsai , Wenxue Wu
IPC分类号: C07D401/14
CPC分类号: C07D401/06
摘要: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.
摘要翻译: 在一个实施方案中,本发明公开了通过创造性地选择溶剂介质来直接制备酸性盐与碱性化合物的不等比例的旋转异构体的方法。 该方法特别可用于制备具有期望优势的药学上有用的盐的特定旋转异构体。
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公开(公告)号:US20050171117A1
公开(公告)日:2005-08-04
申请号:US11093560
申请日:2005-03-30
申请人: Dinesh Gala , Andrew Goodman , Gary Lee , Hongbiao Liao , Martin Schwartz , Suhan Tang , David Tsai , Wenxue Wu
发明人: Dinesh Gala , Andrew Goodman , Gary Lee , Hongbiao Liao , Martin Schwartz , Suhan Tang , David Tsai , Wenxue Wu
IPC分类号: C07D401/14 , A61K31/095 , A61K31/19 , A61K31/194 , A61K31/506 , A61P1/04 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D401/06 , C07D43/14
CPC分类号: C07D401/06
摘要: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.
摘要翻译: 在一个实施方案中,本发明公开了通过创造性地选择溶剂介质来直接制备酸性盐与碱性化合物的不等比例的旋转异构体的方法。 该方法特别可用于制备具有期望优势的药学上有用的盐的特定旋转异构体。
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公开(公告)号:US20050171120A1
公开(公告)日:2005-08-04
申请号:US11089858
申请日:2005-03-25
申请人: Wenxue Wu , Hongbiao Liao , David Tsai , David Andrews , Dinesh Gala , Gary Lee , Martin Schwartz , Timothy McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram Thiruvengadam , Chou-Hang Tann
发明人: Wenxue Wu , Hongbiao Liao , David Tsai , David Andrews , Dinesh Gala , Gary Lee , Martin Schwartz , Timothy McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram Thiruvengadam , Chou-Hang Tann
IPC分类号: C07D241/04 , C07B53/00 , C07B61/00 , C07C45/51 , C07C303/28 , C07C309/73 , C07D295/084 , C07D295/088 , C07D295/185 , C07D295/192 , C07D295/205 , A61K31/495 , A61K31/496
CPC分类号: C07D295/185 , C07B2200/07 , C07C45/512 , C07C67/343 , C07C309/73 , C07D295/088 , C07D295/092 , C07D295/192 , C07D295/205 , C07C49/255 , C07C69/734 , C07C49/84
摘要: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
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5.Stereoselective alkylation of chiral 2-methyl-4-protected piperazines 失效
标题翻译: 手性2-甲基-4-保护的哌嗪的立体选择性烷基化公开(公告)号:US06872826B2
公开(公告)日:2005-03-29
申请号:US10400429
申请日:2003-03-27
申请人: Wenxue Wu , Hongbiao Liao , David J. S. Tsai , David R. Andrews , Dinesh Gala , Gary M. Lee , Martin Lawrence Schwartz , Timothy L. McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram K. Thiruvengadam , Chou-Hang Tann
发明人: Wenxue Wu , Hongbiao Liao , David J. S. Tsai , David R. Andrews , Dinesh Gala , Gary M. Lee , Martin Lawrence Schwartz , Timothy L. McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram K. Thiruvengadam , Chou-Hang Tann
IPC分类号: C07D241/04 , C07B53/00 , C07B61/00 , C07C45/51 , C07C303/28 , C07C309/73 , C07D295/084 , C07D295/088 , C07D295/185 , C07D295/192 , C07D295/205 , C07D295/067
CPC分类号: C07D295/185 , C07B2200/07 , C07C45/512 , C07C67/343 , C07C309/73 , C07D295/088 , C07D295/092 , C07D295/192 , C07D295/205 , C07C49/255 , C07C69/734 , C07C49/84
摘要: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
摘要翻译: 在说明性实施方案中,本发明通过新的立体选择性烷基化方法描述了具有高立体化学纯度的以下化合物和类似化合物的合成:
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6.Stereoselective alkylation of chiral 2-methyl-4-protected piperazines 失效
标题翻译: 手性2-甲基-4-保护的哌嗪的立体选择性烷基化公开(公告)号:US07745626B2
公开(公告)日:2010-06-29
申请号:US11089858
申请日:2005-03-25
申请人: Wenxue Wu , Hongbiao Liao , David J. Tsai , David R. Andrews , Dinesh Gala , Gary M. Lee , Martin Lawrence Schwartz , Timothy L. McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram K. Thiruvengadam , Chou-Hang Tann
发明人: Wenxue Wu , Hongbiao Liao , David J. Tsai , David R. Andrews , Dinesh Gala , Gary M. Lee , Martin Lawrence Schwartz , Timothy L. McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram K. Thiruvengadam , Chou-Hang Tann
IPC分类号: C07D295/023
CPC分类号: C07D295/185 , C07B2200/07 , C07C45/512 , C07C67/343 , C07C309/73 , C07D295/088 , C07D295/092 , C07D295/192 , C07D295/205 , C07C49/255 , C07C69/734 , C07C49/84
摘要: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
摘要翻译: 在说明性实施方案中,本发明通过新的立体选择性烷基化方法描述了具有高立体化学纯度的以下化合物和类似化合物的合成:
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7.Stereoselective Alkylation of Chiral 2-Methly-4 Protected Piperazines 审中-公开
标题翻译: 手性2-甲基-4保护的哌嗪的立体选择性烷基化公开(公告)号:US20100249411A1
公开(公告)日:2010-09-30
申请号:US12748882
申请日:2010-03-29
申请人: Wenxue Wu , Hongbiao Liao , David J.S. Tsai , David R. Andrews , Dinesh Gala , Gary M. Lee , Martin Lawrence Schwartz , Timothy L. McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram K. Thiruvengadam , Chou-Hang Tann
发明人: Wenxue Wu , Hongbiao Liao , David J.S. Tsai , David R. Andrews , Dinesh Gala , Gary M. Lee , Martin Lawrence Schwartz , Timothy L. McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram K. Thiruvengadam , Chou-Hang Tann
IPC分类号: C07D241/04 , C07C309/73 , C07C45/54
CPC分类号: C07D295/185 , C07B2200/07 , C07C45/512 , C07C67/343 , C07C309/73 , C07D295/088 , C07D295/092 , C07D295/192 , C07D295/205 , C07C49/255 , C07C69/734 , C07C49/84
摘要: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
摘要翻译: 在说明性实施方案中,本发明描述了通过新的立体选择性烷基化方法合成具有高立体化学纯度的以下化合物和类似化合物:
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8.Synthesis of quinoline 5-carboxamides useful for the preparation of PDE IV inhibitors 失效
标题翻译: 用于制备PDE IV抑制剂的喹啉5-甲酰胺的合成公开(公告)号:US07129357B2
公开(公告)日:2006-10-31
申请号:US10939740
申请日:2004-09-13
申请人: David R. Andrews , Suhan Tang , Wenxue Wu , Sami Y. Kalliney , Anantha Sudhakar , Christopher Nielsen
发明人: David R. Andrews , Suhan Tang , Wenxue Wu , Sami Y. Kalliney , Anantha Sudhakar , Christopher Nielsen
IPC分类号: C07D215/20 , C07D215/38
CPC分类号: C04B35/632 , C07C229/64 , C07D215/48 , C07D401/12
摘要: In one embodiment, the present application discloses a process for making the compound of the formula:
摘要翻译: 在一个实施方案中,本申请公开了制备下式的化合物的方法:
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9.Synthesis of quinoline 5-carboxamides useful for the preparation of PDE IV inhibitors 失效
标题翻译: 用于制备PDE IV抑制剂的喹啉5-甲酰胺的合成公开(公告)号:US20050124655A1
公开(公告)日:2005-06-09
申请号:US10939740
申请日:2004-09-13
申请人: David Andrews , Suhan Tang , Wenxue Wu , Sami Kalliney , Anantha Sudhakar , Christopher Nielsen
发明人: David Andrews , Suhan Tang , Wenxue Wu , Sami Kalliney , Anantha Sudhakar , Christopher Nielsen
IPC分类号: A61K31/47 , C07C229/64 , C07D215/14 , C07D215/48 , C07D401/12
CPC分类号: C04B35/632 , C07C229/64 , C07D215/48 , C07D401/12
摘要: In one embodiment, the present application discloses a process for making the compound of the formula:
摘要翻译: 在一个实施方案中,本申请公开了制备下式的化合物的方法:
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10.Synthesis of 4-(piperidyl)(2-pyridyl)methanone-(E)-O-methyloxime and salts 失效
标题翻译: 4-(哌啶基)(2-吡啶基)甲酮 - (E)-O-甲基肟及其盐的合成公开(公告)号:US06642385B2
公开(公告)日:2003-11-04
申请号:US10269786
申请日:2002-10-11
申请人: Wenxue Wu , Hongbiao Liao , David J Tsai
发明人: Wenxue Wu , Hongbiao Liao , David J Tsai
IPC分类号: C07D40106
CPC分类号: C07D401/06
摘要: In one embodiment, the present invention describes the synthesis of 4-(piperidyl)(2-pyridyl)methanone-(E)-O-methyloxime dihydrochloride, monohydrochloride and free base, and similar compounds, in high stereochemical purity.
摘要翻译: 在一个实施方案中,本发明描述了具有高立体化学纯度的4-(哌啶基)(2-吡啶基)甲酮 - (E)-O-甲基肟二盐酸盐,一盐酸盐和游离碱以及类似化合物的合成。
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