公开(公告)号：US5507288A

公开(公告)日：1996-04-16

申请号：US434296

申请日：1995-05-03

申请人： Dirk Bocker ,  Hans-Peter Haar ,  Peter Blasberg ,  Reinhard Kotulla

发明人： Dirk Bocker ,  Hans-Peter Haar ,  Peter Blasberg ,  Reinhard Kotulla

IPC分类号： G01N33/52 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495

CPC分类号： A61B5/6822 ,  A61B5/0002 ,  A61B5/14532 ,  A61B2562/0295 ,  Y10S128/903

摘要： Analytical system for monitoring patient blood concentration of a substance to be analyzed, comprising analysis-elements (12) containing reagents and an evaluation instrument comprising a measurement device to measure a change resulting from a reaction of the analyte with the reagents in order to determine, from the measurement values so obtained, analytical data representing element analysis data C.sub.A.In order to allow continuous monitoring of the analyte with good accuracy and a reduced number of invasive sample generation steps it is proposed that the analytical system further comprises (i) a sensor unit (2) portable on the patient body, said sensor unit (2) including a sensor (7) borne on the patient body for the direct and reagent-free measurement of a parameter correlating with the concentration of the analyzed substance and a transmitter for the wireless transmission of data signals; and (ii) a sensor-analysis means to ascertain sensor-analysis data C.sub.S from the measurement values of said parameter measured by said sensor; and the evaluation instrument further comprises a receiver to receive in wireless manner the data signals from the sensor unit (2), calibration means to calibrate the sensor-analysis data C.sub.S on the basis of the element-analysis data C.sub.A and (iii) a data memory for the long-term storage of analytical data, whereby said evaluation instrument forms a central unit (3) of an integrated analysis-element/sensor monitoring system (1).

摘要翻译： 用于监测待分析物质的患者血液浓度的分析系统，包括含有试剂的分析元件（12）和包括测量装置的评估仪器，所述测量装置用于测量由分析物与试剂的反应产生的变化， 从如此获得的测量值，分析数据表示元素分析数据CA。 为了能够以良好的精度和较少数量的侵入性样本生成步骤连续监测分析物，建议分析系统还包括（i）便携式的患者体上的传感器单元（2），所述传感器单元（2 ），其包括承载在患者身上的传感器（7），用于直接和无试剂地测量与分析物质的浓度相关的参数和用于无线传输数据信号的发射器; 以及（ii）传感器分析装置，用于根据由所述传感器测量的所述参数的测量值来确定传感器分析数据CS; 并且所述评估仪器还包括以无线方式接收来自所述传感器单元（2）的数据信号的接收器，用于基于所述元素分析数据CA校准所述传感器分析数据CS的校准装置，以及（iii）数据 用于长期存储分析数据的存储器，由此所述评估仪器形成集成分析元件/传感器监测系统（1）的中央单元（3）。

公开(公告)号：US5786226A

公开(公告)日：1998-07-28

申请号：US619935

申请日：1996-03-18

申请人： Dirk Bocker ,  Gerhard Werner ,  Hans-Peter Haar

发明人： Dirk Bocker ,  Gerhard Werner ,  Hans-Peter Haar

IPC分类号： G01N23/02 ,  G01N21/03 ,  G01N21/27 ,  G01N21/3577 ,  G01N21/59 ,  G01N21/35 ,  G01J5/02 ,  G01N21/25

CPC分类号： G01N21/59 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/0346

摘要： Quantitative transmission spectroscopy where a sample liquid is applied onto a sample carrier having a net in such a manner that the liquid spreads across the meshes of the net. The liquid on the net is exposed to radiation essentially perpendicularly to the net, and the transmitted radiation is detected. The net accomplishes a dosing of the liquid in such a manner that identical meshes include identical quantities of liquid. For a given net, it is possible to derive the amount of liquid, which is located in a mesh and accessible to radiation, from a net constant. Knowing the amount of liquid detected by the radiation, it is possible to use the radiation absorption to calculate the concentration of one or several analytes contained in the sample liquid.

摘要翻译： 定量透射光谱法，其中将样品液体施加到具有网的样品载体上，使得液体跨越网的网格。 网上的液体暴露于基本上垂直于网的辐射，并且检测到透射的辐射。 网以这样的方式完成液体的计量，使得相同的网孔包括相同量的液体。 对于给定的网络，可以从净常数导出位于网格中并且可被辐射获得的液体的量。 知道由辐射检测到的液体量，可以使用辐射吸收来计算样品液体中所含的一种或几种分析物的浓度。

公开(公告)号：US08671543B2

公开(公告)日：2014-03-18

申请号：US13311705

申请日：2011-12-06

申请人： Hans-Peter Haar

发明人： Hans-Peter Haar

IPC分类号： B21D39/02 ,  B23P11/00 ,  B21G1/00 ,  A61B5/00 ,  A61B5/15 ,  A61B5/151

CPC分类号： A61B5/14514 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150419 ,  A61B5/150427 ,  A61B5/150511 ,  A61B5/685 ,  A61B17/205 ,  A61M2037/0053 ,  B21G1/08 ,  Y10T29/49826

摘要： In a process for producing a microneedle (12) that can be inserted into body tissue in which a needle tip (20) and a preferably capillary collecting channel (14) having a distal inlet for body fluid formed at the needle tip (20) are formed, it is provided that at least part of a preform (38) prefabricated from a flat material is shaped into a tubular structure (22) so that the collecting channel (14) is at least substantially annularly closed in the cross-section in the area of the tubular structure (22).

摘要翻译： 在用于制造可插入体针组织中的微针（12）的方法中，其中在针尖（20）处形成有用于体液的远端入口的针尖（20）和优选的毛细收集通道（14） 形成的是，从平坦材料预制的预成型件（38）的至少一部分成形为管状结构（22），使得收集通道（14）在截面中至少基本上环形封闭 管状结构（22）的面积。

公开(公告)号：US08586377B2

公开(公告)日：2013-11-19

申请号：US13588494

申请日：2012-08-17

申请人： Otto Fuerst ,  Hans-Peter Haar

发明人： Otto Fuerst ,  Hans-Peter Haar

IPC分类号： G01N33/48

CPC分类号： G01N33/525 ,  B01L3/5023 ,  B01L2300/0887 ,  B01L2300/161 ,  B01L2400/0406 ,  Y10T156/10 ,  Y10T428/23986 ,  Y10T442/20 ,  Y10T442/2484

摘要： An analytical test element is provided having a surface comprising a chemical detection layer on which a spreading net is disposed, the spreading net being configured to provide for the planar distribution of a liquid sample on the detection layer. The spreading net generally comprises a filament structure coated with a metallic layer that is oxidized at least on one or more surface portions thereof facing the detection layer.

摘要翻译： 提供一种分析测试元件，其具有包括其上设置有扩展网的化学检测层的表面，所述扩展网被配置为提供液体样品在检测层上的平面分布。 扩展网通常包括涂覆有金属层的细丝结构，该金属层至少在其面向检测层的一个或多个表面部分被氧化。

公开(公告)号：US08394035B2

公开(公告)日：2013-03-12

申请号：US12356908

申请日：2009-01-21

申请人： Hans-Peter Haar ,  Herbert Harttig ,  Joachim Hoenes ,  Hans-Juergen Kuhr ,  Ortrud Quarder ,  Dirk Voelkel ,  Volker Zimmer

发明人： Hans-Peter Haar ,  Herbert Harttig ,  Joachim Hoenes ,  Hans-Juergen Kuhr ,  Ortrud Quarder ,  Dirk Voelkel ,  Volker Zimmer

IPC分类号： A61B5/00

CPC分类号： A61B5/150458 ,  A61B5/150022 ,  A61B5/150175 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150427 ,  A61B5/150465 ,  A61B5/150526 ,  A61B5/15115 ,  A61B5/15153 ,  A61B5/15161 ,  A61B5/15169 ,  A61B5/15171

摘要： The invention concerns a device for collecting body fluids which has at least one lancet comprising a lancet body with at least two tips of different lengths. The device is characterized in that it has a selection means with the aid of which only one tip is selected before the lancing. This selection means can have different functions and shapes. The selection means is used to select a tip from a plurality of lancet tips which have different lengths and make only this tip available for use in the lancing process. Since the various tips are attached to a lancet body, it is, for example, possible to use a bending element which bends one of the various tips out of the plane of the lancet body in order to provide only one lancet tip for use. This is especially preferable for lancet tips that are arranged linearly relative to one another.

摘要翻译： 本发明涉及一种用于收集体液的装置，其具有至少一个刺血针，其包括具有不同长度的至少两个尖端的柳叶刀体。 该装置的特征在于其具有选择装置，借助于在穿刺之前仅选择一个尖端。 该选择方式可以具有不同的功能和形状。 选择装置用于从具有不同长度的多个刺血针尖端选择尖端，并且仅使该尖端可用于采血过程。 由于各种尖端附着于柳叶刀体，所以例如可以使用弯曲元件，该弯曲元件将各种尖端中的一个弯曲到柳叶刀体的平面内，以便仅提供一个刺血针头用于使用。 这对于相对于彼此线性布置的刺血针尖特别优选。

公开(公告)号：US08280642B2

公开(公告)日：2012-10-02

申请号：US12233889

申请日：2008-09-19

申请人： Hans-Peter Haar

发明人： Hans-Peter Haar

IPC分类号： G01N33/48 ,  G06F11/00

CPC分类号： G01N33/48792 ,  G01N21/78 ,  G01N21/8483

摘要： An analysis system for determining an analyte of a body fluid comprises a test element and an analysis instrument having a measurement and evaluation unit. The test element has a sample application zone and two analysis zones and a reagent system, whose reaction with the analyte results in a detectable change characteristic for the desired analytical result. The measurement and evaluation unit comprises two analog measuring units, in each of which an analog measurement signal corresponding to one of the analysis zones is generated, two analog-digital converters for digitizing the analog measurement signal, a comparator unit for comparing control data values based on the digitized measurement signals, and a final processing unit, in which, if the determined deviation between the control data values of the digitized measurement signals is less than a predefined value, at least one of the control data values is allowed to pass for further processing into the desired analytical result.

摘要翻译： 用于确定体液分析物的分析系统包括测试元件和具有测量和评估单元的分析仪器。 测试元件具有样品应用区域和两个分析区域和试剂系统，其与分析物的反应产生可检测的变化特征以用于期望的分析结果。 测量和评估单元包括两个模拟测量单元，每个模拟测量单元分别产生与分析区之一相对应的模拟测量信号，两个用于数字化模拟测量信号的模数转换器，用于比较控制数据值的比较单元 对于数字化的测量信号，以及最终处理单元，其中如果所确定的数字化测量信号的控制数据值之间的偏差小于预定值，则允许控制数据值中的至少一个进一步通过 加工成所需的分析结果。

公开(公告)号：US08052618B2

公开(公告)日：2011-11-08

申请号：US12389778

申请日：2009-02-20

申请人： Hans-Peter Haar ,  Karin Schwind ,  Michael Marquant ,  Nigel A. Surridge

发明人： Hans-Peter Haar ,  Karin Schwind ,  Michael Marquant ,  Nigel A. Surridge

IPC分类号： A61B5/151

CPC分类号： A61B5/15174 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150282 ,  A61B5/150335 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150427 ,  A61B5/150519 ,  A61B5/15115 ,  A61B5/15153 ,  A61B5/685

摘要： The invention concerns a process for producing a diagnostic test element for analyzing a body fluid in which a lancing member that can puncture a body part is provided with a collecting channel for body fluid obtained by the puncture, wherein the collecting channel exhibits capillary action, and wherein a sensor member for an optical or electrochemical measurement is connected to the lancing member. According to the invention, the sensor member and the lancing member can be joined together as interlocking connecting components wherein a measuring element of the sensor member is inserted into the collecting channel through an insertion opening of the lancing member.

摘要翻译： 本发明涉及一种生产用于分析身体液体的诊断测试元件的方法，其中穿刺身体部位的穿刺部件设置有通过穿刺获得的体液收集通道，其中收集通道具有毛细作用，并且 其中用于光学或电化学测量的传感器构件连接到所述穿刺构件。 根据本发明，传感器构件和采血构件可以作为互锁连接部件接合在一起，其中传感器构件的测量元件通过穿刺构件的插入孔插入收集通道中。

公开(公告)号：US07985057B2

公开(公告)日：2011-07-26

申请号：US11686176

申请日：2007-03-14

申请人： Hans-Peter Haar

发明人： Hans-Peter Haar

IPC分类号： F04B43/12

CPC分类号： A61M5/14232 ,  A61M5/14228 ,  A61M5/14244 ,  A61M5/16886 ,  A61M5/365 ,  A61M2205/0294 ,  A61M2205/18 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3317 ,  A61M2205/3331 ,  A61M2205/3375 ,  F04B43/082

摘要： The invention relates to a micropump for peristaltic pumping of a liquid medium and to a device which contains a peristaltic micropump and which is for metered administration of a liquid drug.

摘要翻译： 本发明涉及一种用于液体介质的蠕动泵送的微型泵和包含蠕动式微型泵的装置，其用于计量给药液体药物。

公开(公告)号：US07811236B2

公开(公告)日：2010-10-12

申请号：US12122908

申请日：2008-05-19

申请人： Hans List ,  Hans-Peter Haar ,  George Bevan Kirby Meacham ,  Michael Eusemann

发明人： Hans List ,  Hans-Peter Haar ,  George Bevan Kirby Meacham ,  Michael Eusemann

IPC分类号： A61B5/00 ,  A61B5/15 ,  A61B5/157 ,  A61B17/32

CPC分类号： A61B5/15196 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150175 ,  A61B5/15019 ,  A61B5/150419 ,  A61B5/150519 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15119 ,  A61B5/15128 ,  A61B5/1519 ,  A61B5/15194

摘要： A microsampler puncturing system for collecting a body fluid from a body part is described, comprising a sample collection unit having a piercing element, and a puncturing instrument having a drive, by which a sample collection unit is movable on a movement path for piercing the piercing element into the skin of the body part and withdrawing it in a piercing and retraction movement, a setting device for setting the puncturing depth of the piercing wound to be generated, and a control device for controlling the piercing and retraction movement having the following sequentially executed movement phases: a forward phase, a retraction phase, and a collecting phase (S). The setting device is settable independently of the chronological mean of the defined residual puncturing depth (dr), with reference to the collecting phase.

摘要翻译： 描述了一种用于从身体部分收集体液的微量取样器穿刺系统，包括具有刺穿元件的样本收集单元和具有驱动器的穿刺器械，通过该穿刺器具，样本收集单元可在用于刺穿穿孔的移动路径上移动 元件进入身体部分的皮肤并且在穿刺和收缩运动中取出，用于设定要产生的穿刺伤口的穿刺深度的设置装置，以及用于控制穿刺和缩回运动的控制装置，其具有以下顺序执行 移动阶段：前进阶段，退回阶段和收集阶段（S）。 参考收集阶段，设定装置可独立于定义的残留穿刺深度（dr）的时间平均值来设定。

公开(公告)号：US20100227348A1

公开(公告)日：2010-09-09

申请号：US12696665

申请日：2010-01-29

申请人： Wolfgang Petrich ,  Hans-Peter Haar ,  Joachim Hoenes ,  Carina Horn

发明人： Wolfgang Petrich ,  Hans-Peter Haar ,  Joachim Hoenes ,  Carina Horn

IPC分类号： C12Q1/54 ,  C12M1/34

CPC分类号： C12Q1/32 ,  C12Q1/54

摘要： A method is presented for determining the concentration of an analyte in a liquid sample using a reagent system. The reaction of the sample with the reagent system results in a change of the quantity of a fluorophore, the quantity of the fluorophore correlating with the concentration of the analyte, a characteristic measurement variable for the quantity of the fluorophore being measured, and the concentration of the analyte being determined using an evaluation algorithm on the basis of the measurement variable. The reagent system is integrated in an analysis system and the fluorescence lifetime of the fluorophore is used in the ascertainment of the concentration of the analyte.

摘要翻译： 提出了一种使用试剂系统确定液体样品中分析物浓度的方法。 样品与试剂系统的反应导致荧光团量的变化，荧光团的量与分析物的浓度相关，测量的荧光团的量的特征测量变量和浓度 使用基于测量变量的评估算法确定分析物。 试剂系统集成在分析系统中，荧光团的荧光寿命用于确定分析物的浓度。