摘要:
The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
摘要:
The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
摘要:
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
摘要:
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
摘要:
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
摘要:
Use of a compound of formula (I): wherein each R, which are the same or different, is H or C1–C6 alkyl, and X completes a ring which is a substituted triazine having one of the following formulae (II) to (IV): wherein R′ is H or C1–C6 alkyl; or an enol tautomer of a compound of formula (I) in which any of the groups R or R′ is hydrogen; in the manufacture of a medicament for use as a protein tyrosine phosphatase (PTP) inhibitor. Formula (I) embraces 2-methylfervenulone, which can be produced by fermentation of a novel microbial strain. Fermentation of the said strain also produces novel precursors to 2-methylfervenulone having utility as prodrugs.
摘要:
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
摘要:
A method and apparatus for processing an image is described. In one embodiment, the method comprises: receiving a portion of an encoded version of a downsized image and one or more encoded residual images, decoding the portion of the encoded version of the downsized image to create a decoded portion of the downsized image, decoding a portion of at least one or more encoded residual images, enlarging the decoded portion of the portion of the downsized image, and combining the enlarged and decoded portion of the downsized image with a first decoded residual image to create a new image.
摘要:
A data encoder and method encodes color image data. The image data include Y, U and V data. A data image quality level is selected, which corresponds to a compression ratio. The Y data is encoded using a wavelet or wavelet-like compression method in accordance with the selected data image quality level. When the compression ratio is less than a threshold value, indicating a low compression ratio, the U and V data are compressed using a JPEG compression method. Otherwise the U and V data are compressed using the wavelet or wavelet-like compression method. The encoded image data includes an indication of which compression method was used to encode the U and V data. When encoded image data is decoded by a data decoder, the decoder determines which compression method was used to encode the U and V data, and then decodes the encoded image data accordingly.
摘要:
A method and related system of encoding or re-encoding video is disclosed. In the method, video data comprising a sequence of frames is received. For a respective frame in the sequence of frames, a multi-level frame is generated comprising the respective frame and a plurality of copies of the respective frame. Each copy has an associated video resolution level that is a member of a predefined range of video resolution levels, ranging from a highest video resolution level to a lowest video resolution level. The multi-level frame is encoded.