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公开(公告)号：US09869681B2
公开(公告)日：2018-01-16
申请号：US13992589
申请日：2011-12-05
CPC分类号： G01N33/6881 , A61K8/4953 , A61K31/519 , A61K2800/78 , A61Q15/00 , A61Q19/007 , A61Q19/08 , G01N33/6845 , G01N2500/02
摘要： The present invention relates to the use of a compound, suitable for modulating the interaction between first and second partner proteins, or between homologues, mutants, or fragments of said proteins, said first and second proteins being SASPase and filaggrin-2, or FLG2, as an active agent for treating and/or preventing aesthetic defects in the skin, and/or in the appendages thereof, linked to an imbalance in the differentiation and/or proliferation of the cells of the epidermis.
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公开(公告)号：US20140005207A1
公开(公告)日：2014-01-02
申请号：US13992589
申请日：2011-12-05
IPC分类号： A61K31/519 , G01N33/68
CPC分类号： G01N33/6881 , A61K8/4953 , A61K31/519 , A61K2800/78 , A61Q15/00 , A61Q19/007 , A61Q19/08 , G01N33/6845 , G01N2500/02
摘要： The present invention relates to the use of a compound, suitable for modulating the interaction between first and second partner proteins, or between homologues, mutants, or fragments of said proteins, said first and second proteins being SASPase and filaggrin-2, or FLG2, as an active agent for treating and/or preventing aesthetic defects in the skin, and/or in the appendages thereof, linked to an imbalance in the differentiation and/or proliferation of the cells of the epidermis.
摘要翻译： 本发明涉及适用于调节第一和第二配对蛋白之间或所述蛋白质的同系物，突变体或片段之间的相互作用的化合物的用途，所述第一和第二蛋白质是SASPase和丝聚蛋白-2或FLG2， 作为用于治疗和/或预防与皮肤细胞分化和/或增殖不平衡相关的皮肤和/或其附属物中的美学缺陷的活性剂。
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公开(公告)号：US20130324477A1
公开(公告)日：2013-12-05
申请号：US13992564
申请日：2011-12-05
CPC分类号： C07K14/47 , A61K8/606 , A61K8/64 , A61K2800/10 , A61Q19/00 , C07K14/4713 , C07K2319/02 , C07K2319/10 , C07K2319/21 , C07K2319/23 , C07K2319/24 , C07K2319/60 , C12N9/6413 , G01N33/573 , G01N33/6881 , G01N2333/96472 , G01N2500/02
摘要： The invention relates to a peptide isolated from SASpase or FLG2, a fragment or homologue thereof, which can modify the three-dimensional shape of a complex formed by interaction between a first amino acide sequence from Filaggrin-2 and a second amino acid sequence from SASPase.
摘要翻译： 本发明涉及从SASpase或FLG2（其片段或同源物）分离的肽，其可以修饰由来自丝胶蛋白-2的第一氨基酸序列与来自SASPase的第二氨基酸序列之间的相互作用形成的复合物的三维形状 。
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公开(公告)号：US09290553B2
公开(公告)日：2016-03-22
申请号：US13992564
申请日：2011-12-05
CPC分类号： C07K14/47 , A61K8/606 , A61K8/64 , A61K2800/10 , A61Q19/00 , C07K14/4713 , C07K2319/02 , C07K2319/10 , C07K2319/21 , C07K2319/23 , C07K2319/24 , C07K2319/60 , C12N9/6413 , G01N33/573 , G01N33/6881 , G01N2333/96472 , G01N2500/02
摘要： An isolated peptide from skin aspartic protease (SASPase) or filaggrin-2 (FLG2), a fragment or homologue thereof, which can modify the three-dimensional shape of a complex formed by interaction between a first amino acid sequence from filaggrin-2 and a second amino acid sequence from SASPase, is described. The isolated peptide is useful as a target for screening for cosmetic or therapeutic active agents with regard to the skin and/or its appendages.
摘要翻译： 来自皮肤天冬氨酸蛋白酶（SASPase）或丝胶蛋白-2（FLG2）的分离的肽，其片段或同源物，其可以修饰由来自丝胶蛋白-2的第一氨基酸序列与 描述了SASPase的第二个氨基酸序列。 分离的肽可用作筛选关于皮肤和/或其附属物的化妆品或治疗活性剂的靶标。
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5.发明申请COSMETIC USE OF ANNEXIN II-TYPE PROTEINS FOR TREATING DRYNESS OF THE SKIN 审中-公开用于治疗皮肤干燥的新型II型蛋白质的化妆品用途公开(公告)号：US20110098230A1
公开(公告)日：2011-04-28
申请号：US12936320
申请日：2009-04-02
CPC分类号： A61Q19/007 , A61K8/64
摘要： The present invention relates to the use, in particular cosmetic and/or therapeutic use, of annexin II, of polypeptides derived from this protein or of analogues thereof, of a nucleic sequence encoding such a polypeptide or of a modulator of the activity, the stability or the expression of such a polypeptide, in particular for preventing and/or treating the signs of skin dryness.The invention also relates to the use of annexin II, of polypeptides derived from this protein or of analogues thereof, or of a nucleic sequence encoding such a polypeptide, as a marker for evaluating a state of dryness of an epithelium.
摘要翻译： 本发明涉及膜联蛋白II的用途，特别是化妆品和/或治疗用途，其衍生自该蛋白质或其类似物的多肽编码这种多肽或活性调节剂的核酸序列，其稳定性 或这种多肽的表达，特别是用于预防和/或治疗皮肤干燥症状。 本发明还涉及膜联蛋白II来自该蛋白质或其类似物的多肽或编码这种多肽的核酸序列作为评价上皮干燥状态的标记物的用途。
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6.发明申请2-OXOTHIAZOLIDINE 4-CARBOXYLIC ACID COMPOUNDS FOR PROMOTING DESQUAMATION OF THE SKIN 审中-公开用于促进皮肤脱屑的2-氧杂环丁烷4-羧酸化合物公开(公告)号：US20100179200A1
公开(公告)日：2010-07-15
申请号：US12683088
申请日：2010-01-06
IPC分类号： A61K31/426 , A61P17/00
CPC分类号： A61Q19/00 , A61K8/49 , A61K2800/28 , A61Q19/08
摘要： 2-oxothiazolidine-4-carboxylic acid compounds having the structural formula (I): are suited for promoting desquamation of the skin and/or stimulating epidermal renewal and/or combating aging of the skin.
摘要翻译： 具有结构式（I）的2-氧代噻唑烷-4-羧酸化合物：适于促进皮肤脱皮和/或刺激表皮更新和/或抵抗皮肤老化。
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公开(公告)号：US20060009380A1
公开(公告)日：2006-01-12
申请号：US10879056
申请日：2004-06-30
申请人： Bruno Mehul , Dominique Bernard , Lucie Simonetti
发明人： Bruno Mehul , Dominique Bernard , Lucie Simonetti
CPC分类号： C07K14/4728 , A61K8/64 , A61K38/00 , A61K47/42 , A61K48/00 , A61K2800/86 , A61Q19/00 , Y10S514/863
摘要： The invention concerns an isolated polypeptide, of the family of calcium-fixing proteins, a mixture of polypeptides derived from proteolysis of the isolated polypeptide, compositions containing them, the uses of said polypeptide and a cosmetic treatment method for dry skin, hyperkeratosis, parakeratosis, psoriasis, ichthyosis, and neoplasia. The invention also concerns a deoxyribonucleic acid sequence coding for said polypeptide and the uses of said deoxyribonucleic sequence.
摘要翻译： 本发明涉及钙固定蛋白家族的分离的多肽，衍生自分离的多肽的蛋白水解的多肽的混合物，含有它们的组合物，所述多肽的用途和用于干性皮肤，角化过度，角化不全的化妆品处理方法， 牛皮癣，鱼鳞病和瘤形成。 本发明还涉及编码所述多肽的脱氧核糖核酸序列和所述脱氧核糖核酸序列的用途。
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8.发明授权Isolated cathepsin L type cysteine proteases and reducing intercorneocyte cohesion/promoting desquamation therewith 有权分离的组织蛋白酶L型半胱氨酸蛋白酶，并减少角质细胞内聚力/促进脱屑公开(公告)号：US06737055B2
公开(公告)日：2004-05-18
申请号：US09884953
申请日：2001-06-21
IPC分类号： A61K3848
CPC分类号： C12N9/6472 , A61K8/64 , A61K39/00 , A61Q19/00
摘要： Isolated, substantially pure natural or synthetic polypeptides comprising cathepsin L type cysteine proteases, or polypeptide fragments or polypeptide admixtures obtained via proteolysis thereof, are useful for reducing intercorneocyte cohesion and, thus, for promoting desquamation.
摘要翻译： 分离的，基本上纯的包含组织蛋白酶L型半胱氨酸蛋白酶的天然或合成多肽或通过其蛋白水解获得的多肽片段或多肽混合物可用于减少角间细胞内聚，从而促进脱屑。
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公开(公告)号：US09421157B2
公开(公告)日：2016-08-23
申请号：US12306565
申请日：2007-06-29
CPC分类号： A61K8/602 , A61K2800/28 , A61K2800/88 , A61Q5/006 , A61Q19/00 , A61Q19/008
摘要： A cosmetic use of at least one C-glycoside derivative in a composition comprising a physiologically acceptable medium, as a cosmetic agent for promoting the desquamation of the skin and/or the scalp and/or for stimulating epidermal renewal.
摘要翻译： 至少一种C-糖苷衍生物在包含生理学上可接受的培养基的组合物中的化妆用途，作为用于促进皮肤脱皮和/或头皮的化妆品和/或用于刺激表皮更新。
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10.发明申请COSMETIC USE OF A LYSATE OF BIFIDOBACTERIUM SPECIES FOR TREATING BODY ODOR 审中-公开用于处理身体气味的双歧杆菌物种的化学使用公开(公告)号：US20130129653A1
公开(公告)日：2013-05-23
申请号：US13641799
申请日：2011-04-22
摘要： The present invention is directed toward protecting the cosmetic use of at least an effective amount of a lysate of at least one microorganism of the genus Bifidobacterium species, or a fraction thereof, for preventing and/or treating body odor.
摘要翻译： 本发明旨在保护至少有效量的至少一种双歧杆菌属物种的微生物或其一部分的裂解物的化妆品用途，以防止和/或治疗身体的气味。
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