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公开(公告)号:US20060258845A1
公开(公告)日:2006-11-16
申请号:US11329987
申请日:2006-01-11
申请人: Donald Awrey , Teresa McGrath , Vladimir Romanov
发明人: Donald Awrey , Teresa McGrath , Vladimir Romanov
CPC分类号: C07K7/06 , C07K2299/00 , C12N9/001
摘要: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译: 本发明涉及病原菌的新型药物靶标。 因此,本发明提供了包含SEQ ID NO:4所示氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。
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公开(公告)号:US20140033835A1
公开(公告)日:2014-02-06
申请号:US13562762
申请日:2012-07-31
申请人: Jan Hendrikse , Vladimir Romanov
发明人: Jan Hendrikse , Vladimir Romanov
IPC分类号: G01N1/02
CPC分类号: G01N1/44 , G01N2001/002 , H01J49/049
摘要: A sample introduction system configured for introducing analytes of a solid phase micro extraction (SPME) sample into an analytical instrument system (e.g., mass spectrometer) is described. The sample introduction system includes a pressure vessel configured with an inlet port via which a probe portion (e.g., SPME fiber) of a SPME assembly is received into a sealed volume of the pressure vessel. The probe portion of the SPME assembly is coated with an extracting phase material, the analytes being absorbed into and/or adsorbed onto the extracting phase material. The pressure vessel is configured for providing an environment in which desorption of the analytes from the extracting phase material occurs at a gaseous pressure which is substantially less than atmospheric pressure (e.g., less than 100 mTorr). The desorbed analytes are then directed to the vacuum chamber of the analytical instrument system via an outlet port of the pressure vessel.
摘要翻译: 描述了配置用于将固相微萃取(SPME)样品的分析物引入分析仪器系统(例如质谱仪)中的样品引入系统。 样品引入系统包括配置有入口的压力容器,SPME组件的探针部分(例如,SPME纤维)经由该入口接收到压力容器的密封体积中。 SPME组件的探针部分涂覆有萃取相材料,分析物被吸收到和/或吸附到萃取相材料上。 压力容器被配置为提供一种环境,其中分析物从萃取相材料中的解吸附在基本上小于大气压(例如小于100mTorr)的气体压力下发生。 解吸的分析物然后通过压力容器的出口导入分析仪器系统的真空室。
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公开(公告)号:US07799547B2
公开(公告)日:2010-09-21
申请号:US11329987
申请日:2006-01-11
CPC分类号: C07K7/06 , C07K2299/00 , C12N9/001
摘要: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译: 本发明涉及病原菌的新型药物靶标。 因此,本发明提供了包含SEQ ID NO:4所示氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。
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公开(公告)号:US20180136165A1
公开(公告)日:2018-05-17
申请号:US15569822
申请日:2016-04-28
申请人: Jan Hendrikse , Vladimir Romanov , Udo Verkerk , Alan Hopkinson
发明人: Jan Hendrikse , Vladimir Romanov , Udo Verkerk , Alan Hopkinson
CPC分类号: G01N27/64 , G01N27/62 , G01N27/622 , G01N27/68 , H01J49/145
摘要: The present disclosure relates to an ion exchange process, as well as a process and system for detecting nitrates, which employ a class of dopants comprising at least two functional groups capable of simultaneous convergent hydrogen bonding with a nitrate ion. In an aspect, the present disclosure provides an ion exchange process for forming a negatively charged nitrate-dopant ion analyte for analysis by a spectrometry analysis instrument, comprising: providing a gas comprising a dopant in both neutral and ionized forms; contacting a nitrate-containing sample with the gas comprising the dopant and thereby desorbing a nitrate ion from the sample to form a negatively charged nitrate-dopant ion analyte and replacing the desorbed nitrate ion with a negatively charged ionized dopant molecule; wherein the dopant is an organic compound comprising two or more carbon atoms and two or more functional groups capable of simultaneous convergent hydrogen bonding with a nitrate ion; or the dopant is an organic compound comprising at least two carbon atoms and only a single functional group capable of hydrogen bonding with a nitrate ion, which group is a —COOH functional group, and where the carbon atom of the —COOH functional group is bonded directly to another carbonyl group; and with the proviso that the dopant is not lactic acid, a lactic acid salt or a compound that forms lactate ions upon ionization.
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公开(公告)号:US09134208B2
公开(公告)日:2015-09-15
申请号:US13562762
申请日:2012-07-31
申请人: Jan Hendrikse , Vladimir Romanov
发明人: Jan Hendrikse , Vladimir Romanov
CPC分类号: G01N1/44 , G01N2001/002 , H01J49/049
摘要: A sample introduction system configured for introducing analytes of a solid phase micro extraction (SPME) sample into an analytical instrument system (e.g., mass spectrometer) is described. The sample introduction system includes a pressure vessel configured with an inlet port via which a probe portion (e.g., SPME fiber) of a SPME assembly is received into a sealed volume of the pressure vessel. The probe portion of the SPME assembly is coated with an extracting phase material, the analytes being absorbed into and/or adsorbed onto the extracting phase material. The pressure vessel is configured for providing an environment in which desorption of the analytes from the extracting phase material occurs at a gaseous pressure which is substantially less than atmospheric pressure (e.g., less than 100 mTorr). The desorbed analytes are then directed to the vacuum chamber of the analytical instrument system via an outlet port of the pressure vessel.
摘要翻译: 描述了配置用于将固相微萃取(SPME)样品的分析物引入分析仪器系统(例如质谱仪)中的样品引入系统。 样品引入系统包括配置有入口的压力容器,SPME组件的探针部分(例如,SPME纤维)经由该入口接收到压力容器的密封体积中。 SPME组件的探针部分涂覆有萃取相材料,分析物被吸收到和/或吸附到萃取相材料上。 压力容器被配置为提供一种环境,其中分析物从萃取相材料中的解吸附在基本上小于大气压(例如小于100mTorr)的气体压力下发生。 解吸的分析物然后通过压力容器的出口导入分析仪器系统的真空室。
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公开(公告)号:US20060003983A1
公开(公告)日:2006-01-05
申请号:US11171076
申请日:2005-06-30
申请人: Andrei Reshetnikov , Igor Zalevsky , Jury Kemov , Andrei Ivanov , Artashes Karmenyan , Alexandr Gradjushko , Vladimir Laptev , Nataliya Neugodova , Olga Abakumova , Valery Privalov , Alexandr Lappa , Vladimir Romanov
发明人: Andrei Reshetnikov , Igor Zalevsky , Jury Kemov , Andrei Ivanov , Artashes Karmenyan , Alexandr Gradjushko , Vladimir Laptev , Nataliya Neugodova , Olga Abakumova , Valery Privalov , Alexandr Lappa , Vladimir Romanov
IPC分类号: A61K31/409 , A61K31/555 , C07D487/22
CPC分类号: A61K49/0013 , A61K41/0057 , A61K41/0071 , C07D487/22
摘要: The invention relates to medicine and concerns a photosensitizer for detecting and curing tumors. The inventive photosensitizer is embodied in the form of a composition containing chlorin in the form of salt and alkali metals. The chlorin is composed of 80-90% of chlorin e6, 5-20 of purpurin 5 and the rest being purpurin 18-chlorin p6. Said photosensitizer is produced by extracting Spirulina biomass with the aid of acetone. Afterwards said biomass is exposed to acid treatment, neutralization, hydrolysis, extraction of pheophorbide a, dissolution in acetone, addition of a strong base, neutralization and reprecipitation of chlorin e6.
摘要翻译: 本发明涉及药物,涉及用于检测和治愈肿瘤的光敏剂。 本发明的光敏剂以含有盐和碱金属形式的二氢卟酚的组合物的形式体现。 二氢卟酚由80%至90%的二氢卟酚,5-20的紫草素组成,其余为紫草素18-二氢卟酚6。 所述光敏剂是借助丙酮提取螺旋藻生物质来生产的。 之后,生物量暴露于酸处理,中和,水解,脱镁叶酸a的提取,丙酮溶解,加碱强碱,中和和二氢卟酚6重新沉淀。
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