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公开(公告)号：US20060172352A1
公开(公告)日：2006-08-03
申请号：US11400698
申请日：2006-04-06
申请人： Donald Coffey , Alan Partin , Robert Getzenberg
发明人： Donald Coffey , Alan Partin , Robert Getzenberg
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , C07K14/47 , Y10S436/813
摘要： Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are substantially purified polypeptides and nucleotide sequences encoding the NMPs of the invention.
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2.发明申请NUCLEAR MATRIX PROTEIN ALTERATIONS ASSOCIATED WITH COLON CANCER AND COLON METASTASIS TO THE LIVER AND USES THEREOF 审中-公开与癌症相关的核基质蛋白质变体和对肝脏的结肠分化及其用途公开(公告)号：US20070238194A1
公开(公告)日：2007-10-11
申请号：US11675732
申请日：2007-02-16
IPC分类号： G01N33/574
CPC分类号： C07K14/4748 , C07K14/47 , G01N33/57419
摘要： Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-gel electrophoresis or by specific binding partners, such as antibodies.
摘要翻译： 可用于诊断结肠增生性疾病的蛋白质存在于核基质蛋白制剂中，可以通过分子量，等电点和氨基酸序列来表征。 可以例如通过2D凝胶电泳或特异性结合配偶体（例如抗体）鉴定蛋白质。
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3.发明申请Novel bladder matrix protein peptides and methods of detection of bladder cancer 失效新型膀胱基质蛋白肽和膀胱癌检测方法公开(公告)号：US20060154311A1
公开(公告)日：2006-07-13
申请号：US11292278
申请日：2005-12-02
申请人： Robert Getzenberg
发明人： Robert Getzenberg
CPC分类号： C07K16/3038 , C07K14/47 , C07K14/82 , C07K2317/34 , G01N33/574 , G01N33/57407 , G01N33/57496
摘要： Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are substantially purified polypeptides and polynucleotide sequences encoding the NMPs, and particularly, those of BLCA-1, and antibodies thereto.
摘要翻译： 提供以组织中定义的表达为特征的核基质蛋白（NMP）。 这些NMP是诊断和监测细胞恶性肿瘤阶段以及治疗与NMP相关的细胞增殖性疾病的有用标记。 还提供了基本纯化的多肽和编码NMP的多核苷酸序列，特别是BLCA-1的多核苷酸序列及其抗体。
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公开(公告)号：US20050186644A1
公开(公告)日：2005-08-25
申请号：US11090289
申请日：2005-03-28
申请人： Robert Getzenberg
发明人： Robert Getzenberg
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K16/18 , G01N33/574 , G01N33/68 , G01N33/53 , C07K16/30
CPC分类号： G01N33/57407 , A61K38/00 , A61K48/00 , C07K14/47 , C07K16/18 , G01N33/57488 , G01N33/6872 , G01N33/6893 , G01N2500/00 , G01N2800/34
摘要： Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are substantially purified polypeptides and nucleotide sequences encoding the NMPs of the invention.
摘要翻译： 提供以组织中定义的表达为特征的核基质蛋白（NMP）。 这些NMP是诊断和监测细胞恶性肿瘤阶段以及治疗与NMP相关的细胞增殖性疾病的有用标记。 还提供了基本纯化的多肽和编码本发明的NMP的核苷酸序列。
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5.发明申请Early prostate cancer antigens (epca), polynucleotide sequences encoding them, and their use 失效早期前列腺癌抗原（epca），编码它们的多核苷酸序列及其用途公开(公告)号：US20060148011A1
公开(公告)日：2006-07-06
申请号：US10514735
申请日：2004-03-01
申请人： Robert Getzenberg
发明人： Robert Getzenberg
IPC分类号： G01N33/574
CPC分类号： C07K14/4748 , C07K14/47 , G01N33/57434 , Y10T436/143333
摘要： A novel prostate cancer marker is described that is found in cancerous and normal prostate cells of individuals that have prostate cancer but is not found in the prostate of individuals without prostate cancer. The marker also is present in normal tissue adjacent to tumor tissue in individuals having prostate cancer. The marker, however, is absent in the prostate of individuals without prostate cancer. Methods employing the novel prostate cancer marker of the invention to predict the occurrence of the prostate disease, monitor the progression of prostate cancer and effect the treatment of prostate cancer, also are described.
摘要翻译： 描述了一种新型前列腺癌标记，其在具有前列腺癌但在前列腺癌的个体的前列腺中未发现的个体的癌性和正常前列腺细胞中发现。 该标记物也存在于患有前列腺癌的个体中与肿瘤组织相邻的正常组织中。 然而，在没有前列腺癌的个体的前列腺中不存在该标记。 还描述了使用本发明的新型前列腺癌标志物来预测前列腺疾病的发生，监测前列腺癌的进展和影响前列腺癌的治疗的方法。
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公开(公告)号：US20050287567A1
公开(公告)日：2005-12-29
申请号：US11133432
申请日：2005-05-20
申请人： Robert Getzenberg
发明人： Robert Getzenberg
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/574
CPC分类号： G01N33/6893 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57434 , G01N2800/342 , G01N2800/52
摘要： A serum assay for JM-27 identifies individuals having benign prostate hyperplasia (BPH). By means of the serum assay, methods of diagnosing BPH, methods of determining the severity of BPH, methods of monitoring the course of BPH therapy and methods of monitoring the progression of BPH are performed.
摘要翻译： JM-27的血清测定法鉴定出具有良性前列腺增生（BPH）的个体。 通过血清测定，进行诊断BPH的方法，确定BPH严重程度的方法，监测BPH治疗过程的方法和监测BPH进展的方法。
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7.发明申请Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver, and uses thereof 失效与结肠癌和结肠转移到肝脏相关的核基质蛋白质改变及其用途公开(公告)号：US20050221372A1
公开(公告)日：2005-10-06
申请号：US11133177
申请日：2005-05-20
IPC分类号： G01N33/53 , C07K14/47 , C07K14/82 , C07K16/32 , C12N15/02 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/566 , G01N33/574 , G01N33/577 , C07H21/04
CPC分类号： C07K14/4748 , C07K14/47 , G01N33/57419
摘要： Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-gel electrophoresis or by specific binding partners, such as antibodies.
摘要翻译： 可用于诊断结肠增生性疾病的蛋白质存在于核基质蛋白制剂中，可以通过分子量，等电点和氨基酸序列来表征。 可以例如通过2D凝胶电泳或特异性结合配偶体（例如抗体）鉴定蛋白质。
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8.发明申请Nuclear matrix proteins, polynucleotide sequences encoding them, and their use 审中-公开核基质蛋白，编码它们的多核苷酸序列及其用途公开(公告)号：US20050181418A1
公开(公告)日：2005-08-18
申请号：US11080836
申请日：2005-03-16
申请人： Robert Getzenberg
发明人： Robert Getzenberg
IPC分类号： G01N33/53 , A61K31/7088 , A61K48/00 , A61P35/00 , A61P35/04 , C07K14/47 , C07K14/82 , C07K16/32 , C12N15/12 , C12P21/08 , G01N33/574 , C12Q1/68 , C07K16/30
CPC分类号： C07K14/47
摘要： Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue, particularly prostate tissue, are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are substantially purified polypeptides and nucleotide sequences encoding the NMPs of the invention.
摘要翻译： 提供了以组织，特别是前列腺组织中定义的表达为特征的核基质蛋白（NMP）。 这些NMP是诊断和监测细胞恶性肿瘤阶段以及治疗与NMP相关的细胞增殖性疾病的有用标记。 还提供了基本纯化的多肽和编码本发明的NMP的核苷酸序列。
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