公开(公告)号：US06186012B1

公开(公告)日：2001-02-13

申请号：US09222627

申请日：1998-12-29

申请人： Donald V. Kenny ,  Deborah L. Smith ,  Richard A. Severance

发明人： Donald V. Kenny ,  Deborah L. Smith ,  Richard A. Severance

IPC分类号： G01N100

CPC分类号： G01N1/28 ,  G01N30/02 ,  G01N30/7206

摘要： A manipulator apparatus, system and method for measuring analytes present in sample tubes. The manipulator apparatus includes a housing having a central bore with an inlet end and outlet end; a plunger mechanism with at least a portion thereof slideably disposed for reciprocal movement within the central bore, the plunger mechanism having a tubular gas channel with an inlet end and an outlet end, the gas channel inlet end disposed in the same direction as said inlet end of the central bore, wherein the inlet end of said plunger mechanism is adapted for movement so as to expel a sample tube inserted in the bore at the outlet end of the housing, the inlet end of the plunger mechanism is adapted for connection to gas supply; a first seal is disposed in the housing for sealing between the central bore and the plunger mechanism; a second seal is disposed at the outlet end of the housing for sealing between the central bore and a sample tube; a holder mounted on the housing for holding the sample tube; and a biasing mechanism for returning the plunger mechanism to a starting position.

摘要翻译： 用于测量样品管中存在的分析物的机械手装置，系统和方法。 机械手装置包括具有中心孔的壳体，该中心孔具有入口端和出口端; 柱塞机构，其至少一部分可滑动地设置成用于在中心孔内往复运动，柱塞机构具有带入口端和出口端的管状气体通道，气体通道入口端设置在与所述入口端相同的方向上 的中心孔的入口端，其中所述柱塞机构的入口端适于运动，以便排出在壳体的出口端处插入孔中的样品管，柱塞机构的入口端适于连接到气体供应 ; 第一密封件设置在壳体中用于密封中心孔和柱塞机构之间; 第二密封件设置在壳体的出口端处，用于密封中心孔和样品管之间; 安装在壳体上以保持样品管的保持器; 以及用于将柱塞机构返回到起始位置的偏置机构。

公开(公告)号：US4982097A

公开(公告)日：1991-01-01

申请号：US354643

申请日：1989-05-19

申请人： Laurence E. Slivon ,  Donald V. Kenny ,  Richard A. Severance

发明人： Laurence E. Slivon ,  Donald V. Kenny ,  Richard A. Severance

IPC分类号： G01N1/00 ,  G01N30/30 ,  G01N30/72 ,  H01J49/04

CPC分类号： H01J49/0431 ,  H01J49/0404 ,  H01J49/049 ,  G01N1/22 ,  G01N2030/3038 ,  G01N30/7253

摘要： This invention is designed to serve as an interface between a liquid chromatograph and a conventional or tandem mass spectrometer (LC/MS, LC/MS/MS). It may also be used for liquid sampling without prior separation of analytes by a liquid chromatograph. This invention differs from prior art in that vaporization of the analytical sample (LC eluent) occurs through the action of condensing pressurized steam on the exterior of a low thermal mass metal capillary, while the aqueous LC eluent is flowing through the metal capillary. The steam is obtained by heating a small volume of water sealed within the device. LC eluent entering the capillary results in localized cooling and subsequent condensation of the pressurized steam on the outer surface of the capillary. The process of condensation deposits energy to the capillary equivalent to the latent heat of vaporization of water. This energy results in flash vaporization of the LC eluent within the capillary. Condensed water flows along the outer wall of the metal capillary where it is returned to the trapped liquid reservoir for re-vaporization. Energy coupling to the LC eluent is substantially more efficient than methods used in prior art interface devices. This invention minimizes overheating of temperature sensitive analytes separated by the LC and rapidly self compensates for changes in eluent flow or eluent composition without the need for adjustment in operating temperature. This invention eliminates the need for aerosol desolvation prior to ionization.

摘要翻译： 本发明设计用作液相色谱仪和常规或串联质谱仪（LC / MS，LC / MS / MS）之间的界面。 它也可用于液体取样，而无需用液相色谱仪分离分析物。 本发明与现有技术的不同之处在于，分析样品的蒸发（LC洗脱液）通过在低热质量金属毛细管的外部冷凝加压蒸汽的作用而水溶液LC洗脱液流过金属毛细管而发生。 通过加热密封在装置内的少量水来获得蒸汽。 进入毛细管的LC洗脱液导致局部冷却，并随后冷凝加压蒸汽在毛细管外表面。 冷凝过程将毛细管的能量与水的蒸发潜热相当。 该能量导致毛细管内LC洗脱液的闪蒸。 冷凝水沿着金属毛细管的外壁流动，在此被返回到被捕获的液体储存器中，用于再蒸发。 与LC洗脱液的能量耦合比现有技术界面装置中使用的方法显着更有效。 本发明使由LC分离的温度敏感性分析物的过热最小化，并快速自我补偿洗脱剂流动或洗脱液组成的变化，而不需要调整工作温度。 本发明消除了在电离之前气溶胶去溶剂化的需要。

公开(公告)号：US4845364A

公开(公告)日：1989-07-04

申请号：US161546

申请日：1988-02-29

申请人： Carl A. Alexander ,  Julius S. Ogden ,  Richard A. Severance

发明人： Carl A. Alexander ,  Julius S. Ogden ,  Richard A. Severance

IPC分类号： H01J49/14

CPC分类号： H01J49/142

摘要： An improved ion source for characterization of a surface of a sample including a housing oriented about a central axis, Z; a magnet cooperatively disposed within the housing for producing a magnetic field along the Z axis direction an anode radially disposed within the housing and within the magnetic field of the magnet that defines an annular ionization chamber having an open annular space and further forming a central tubular space about the Z axis; a cathode cooperatively disposed at the anode and within the annular ionization chamber; an extractor grids means cooperatively disposed within the housing so as to form a boundary of the ionization chamber; annular focusing rings disposed on the housing and externally to the extractor grids for focusing ions emerging therefrom; neutralizer filament cooperatively disposed with focusing rings; a central lens cooperatively disposed about the central axis Z in the central tubular space formed by the anode and adapted to accept ions and neutrals emanating from a sample; an entrance grid disposed at the sample end of the central lens; a second ionizer disposed along the length of the central lens; an exit grid for directing ions toward a measurement instrument such as a mass spectrometer; and an input gas pipe cooperatively disposed with the housing and anode so as to supply gas to the ionization chamber. A shield is preferably used to shield the apparatus from electromagnetic interference.

摘要翻译： 用于表征样品表面的改进的离子源，包括围绕中心轴Z定向的壳体; 协同地设置在壳体内的磁体，用于产生沿着Z轴方向的磁场，阳极，径向地设置在壳体内并且在磁体的磁场内，该磁体限定具有开放环形空间的环形电离室，并进一步形成中心管状空间 关于Z轴; 阴极，协同地设置在阳极和环形电离室内; 提取器网格协同地设置在壳体内，以便形成电离室的边界; 环形聚焦环设置在壳体上并且在提取器栅格的外部，用于聚焦离开其的离子; 中和器长丝与聚焦环协同配置; 中心透镜在由阳极形成的中心管状空间中围绕中心轴线Z配合设置并适于接收从样品发出的离子和中性粒子; 布置在中心透镜的样品端的入口格栅; 沿着所述中心透镜的长度设置的第二离子发生器; 用于将离子引导到诸如质谱仪的测量仪器的出口格栅; 以及与所述壳体和阳极配合配置的输入气体管道，以向所述电离室供应气体。 优选地使用屏蔽来屏蔽设备免受电磁干扰。