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1.发明授权Vaporization device for continuous introduction of liquids into a mass spectrometer 失效用于将液体连续引入质谱仪的气化装置
公开(公告)号：US4982097A
公开(公告)日：1991-01-01
申请号：US354643
申请日：1989-05-19
CPC分类号： H01J49/0431 , H01J49/0404 , H01J49/049 , G01N1/22 , G01N2030/3038 , G01N30/7253
摘要： This invention is designed to serve as an interface between a liquid chromatograph and a conventional or tandem mass spectrometer (LC/MS, LC/MS/MS). It may also be used for liquid sampling without prior separation of analytes by a liquid chromatograph. This invention differs from prior art in that vaporization of the analytical sample (LC eluent) occurs through the action of condensing pressurized steam on the exterior of a low thermal mass metal capillary, while the aqueous LC eluent is flowing through the metal capillary. The steam is obtained by heating a small volume of water sealed within the device. LC eluent entering the capillary results in localized cooling and subsequent condensation of the pressurized steam on the outer surface of the capillary. The process of condensation deposits energy to the capillary equivalent to the latent heat of vaporization of water. This energy results in flash vaporization of the LC eluent within the capillary. Condensed water flows along the outer wall of the metal capillary where it is returned to the trapped liquid reservoir for re-vaporization. Energy coupling to the LC eluent is substantially more efficient than methods used in prior art interface devices. This invention minimizes overheating of temperature sensitive analytes separated by the LC and rapidly self compensates for changes in eluent flow or eluent composition without the need for adjustment in operating temperature. This invention eliminates the need for aerosol desolvation prior to ionization.
摘要翻译： 本发明设计用作液相色谱仪和常规或串联质谱仪（LC / MS，LC / MS / MS）之间的界面。 它也可用于液体取样，而无需用液相色谱仪分离分析物。 本发明与现有技术的不同之处在于，分析样品的蒸发（LC洗脱液）通过在低热质量金属毛细管的外部冷凝加压蒸汽的作用而水溶液LC洗脱液流过金属毛细管而发生。 通过加热密封在装置内的少量水来获得蒸汽。 进入毛细管的LC洗脱液导致局部冷却，并随后冷凝加压蒸汽在毛细管外表面。 冷凝过程将毛细管的能量与水的蒸发潜热相当。 该能量导致毛细管内LC洗脱液的闪蒸。 冷凝水沿着金属毛细管的外壁流动，在此被返回到被捕获的液体储存器中，用于再蒸发。 与LC洗脱液的能量耦合比现有技术界面装置中使用的方法显着更有效。 本发明使由LC分离的温度敏感性分析物的过热最小化，并快速自我补偿洗脱剂流动或洗脱液组成的变化，而不需要调整工作温度。 本发明消除了在电离之前气溶胶去溶剂化的需要。
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2.发明申请Surface Sampling Probe for Field Portable Surface Sampling Mass Spectrometer 审中-公开现场便携式表面采样质谱仪的表面采样探头公开(公告)号：US20100096544A1
公开(公告)日：2010-04-22
申请号：US12579782
申请日：2009-10-15
申请人： Laurence E. Slivon , Donald V. Kenny , Carl A. Alexander , Julius S. Ogden , Lee A. Siers , Timothy L. Hayes , Lindy E. Dejarme
发明人： Laurence E. Slivon , Donald V. Kenny , Carl A. Alexander , Julius S. Ogden , Lee A. Siers , Timothy L. Hayes , Lindy E. Dejarme
CPC分类号： H01J49/0022 , H01J49/04
摘要： A portable detection device includes a surface sampling probe connected to a mass spectrometer, preferably mounted on a portable cart, and a transfer line for transporting samples from the probe to the mass spectrometer. The surface sampling probe is formed from a circular block or disk of metal such as copper and is provided with various holes in which cartridge heaters are located. The disk is preferably electroplated with nickel and then gold to allow for efficient heat transfer to the surface to be sampled. With this arrangement, in addition to other advantages, the presence of very low volatile or non-volatile materials may be determined.
摘要翻译： 便携式检测装置包括连接到质谱仪的表面采样探针，优选安装在便携式推车上，以及用于将样品从探针输送到质谱仪的传输线。 表面采样探针由诸如铜的金属的圆形块或盘形成，并且设置有盒式加热器所在的各种孔。 该盘优选用镍电镀，然后镀金以允许有效的热传递到待采样的表面。 利用这种布置，除了其它优点之外，可以确定非常低挥发性或非挥发性材料的存在。
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公开(公告)号：US06186012B1
公开(公告)日：2001-02-13
申请号：US09222627
申请日：1998-12-29
IPC分类号： G01N100
CPC分类号： G01N1/28 , G01N30/02 , G01N30/7206
摘要： A manipulator apparatus, system and method for measuring analytes present in sample tubes. The manipulator apparatus includes a housing having a central bore with an inlet end and outlet end; a plunger mechanism with at least a portion thereof slideably disposed for reciprocal movement within the central bore, the plunger mechanism having a tubular gas channel with an inlet end and an outlet end, the gas channel inlet end disposed in the same direction as said inlet end of the central bore, wherein the inlet end of said plunger mechanism is adapted for movement so as to expel a sample tube inserted in the bore at the outlet end of the housing, the inlet end of the plunger mechanism is adapted for connection to gas supply; a first seal is disposed in the housing for sealing between the central bore and the plunger mechanism; a second seal is disposed at the outlet end of the housing for sealing between the central bore and a sample tube; a holder mounted on the housing for holding the sample tube; and a biasing mechanism for returning the plunger mechanism to a starting position.
摘要翻译： 用于测量样品管中存在的分析物的机械手装置，系统和方法。 机械手装置包括具有中心孔的壳体，该中心孔具有入口端和出口端; 柱塞机构，其至少一部分可滑动地设置成用于在中心孔内往复运动，柱塞机构具有带入口端和出口端的管状气体通道，气体通道入口端设置在与所述入口端相同的方向上 的中心孔的入口端，其中所述柱塞机构的入口端适于运动，以便排出在壳体的出口端处插入孔中的样品管，柱塞机构的入口端适于连接到气体供应 ; 第一密封件设置在壳体中用于密封中心孔和柱塞机构之间; 第二密封件设置在壳体的出口端处，用于密封中心孔和样品管之间; 安装在壳体上以保持样品管的保持器; 以及用于将柱塞机构返回到起始位置的偏置机构。
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公开(公告)号：US5645072A
公开(公告)日：1997-07-08
申请号：US535929
申请日：1995-09-28
IPC分类号： A61B5/08 , G01N33/00 , G01N33/497 , A61B5/09
CPC分类号： A61B5/0813 , G01N33/0009 , G01N33/497
摘要： The apparatus of the present invention is a combination of a breath interface and an external exposure dosimeter interface to a chemical analysis device, all controlled by an electronic processor for quantitatively analyzing chemical analysis data from both the breath interface and the external exposure dosimeter for determining internal tissue dose. The method of the present invention is a combination of steps of measuring an external dose, measuring breath content, then analyzing the external dose and breath content and determining internal tissue dose.
摘要翻译： 本发明的装置是呼吸界面和化学分析装置的外部曝光剂量计界面的组合，全部由电子处理器控制，用于定量分析来自呼吸界面和外部曝光剂量计的化学分析数据，用于确定内部 组织剂量。 本发明的方法是测量外部剂量，测量呼吸含量，然后分析外部剂量和呼吸含量并确定内部组织剂量的步骤的组合。
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公开(公告)号：US5042501A
公开(公告)日：1991-08-27
申请号：US518010
申请日：1990-05-01
申请人： Donald V. Kenny , Thomas J. Kelly
发明人： Donald V. Kenny , Thomas J. Kelly
IPC分类号： A61B5/087 , A61B5/097 , G01N33/497 , H01J49/04
CPC分类号： G01N33/497 , A61B5/0878 , A61B5/097
摘要： Apparatus and method for providing breath for introduction to a measuring device such as a mass spectrometer. The apparatus includes a mouthpiece for interfacing a subject with the apparatus; a tube for carrying exhaled breath from the subject to the inlet of a mixing chamber; a mixing chamber having an inlet, sample outlet and exit tube, that provides a residence time for the exhaled breath sufficient to mix the breath and provide an adequate sample to the measuring device; and heating apparatus for maintaining the apparatus above a temperature where condensation of vapor occurs.
摘要翻译： 用于提供呼吸以引入诸如质谱仪的测量装置的装置和方法。 该装置包括：用于使受试者与装置接合的接口管; 用于将呼吸气从受试者携带到混合室的入口的管; 具有入口，样本出口和出口管的混合室，其为呼出的呼吸提供足以混合呼吸并向测量装置提供足够的样品的停留时间; 以及用于将装置维持在发生蒸气冷凝的温度以上的加热装置。
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