专利检索 ap:("Donna Ward" OR "Andrew Watt" OR "Brenda Baker" OR "Timothy Vickers" OR "Kenneth Dobie" OR "Bryan Kraynack") AND inv:"Andrew Watt" 第 1 页

1.

发明申请
Modulation of the RNA interference pathway 有权
标题翻译：调节RNA干扰途径

公开(公告)号：US20050037387A1

公开(公告)日：2005-02-17

申请号：US10852630

申请日：2004-05-24

申请人： Donna Ward , Andrew Watt , Brenda Baker , Timothy Vickers , Kenneth Dobie , Bryan Kraynack

发明人： Donna Ward , Andrew Watt , Brenda Baker , Timothy Vickers , Kenneth Dobie , Bryan Kraynack

IPC分类号： C07H21/02 , C12N20060101 , C12N15/11 , C12N15/113 , C12Q1/68

CPC分类号： C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/10 , C12N2320/50 , C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the RNAi pathway. The compositions comprise oligonucleotides, targeted to nucleic acid molecules encoding EIF2C2. Methods of using these compounds for modulation of RNA interference as well as EIF2C2 expression and for diagnosis and treatment of disease associated with expression of EIF2C2 are provided. Also provided are compounds, compositions and methods for modulating the expression of DDX36. The compositions comprise oligonucleotides, targeted to nucleic acid encoding DDX36. Methods of using these compounds for modulation of DDX36 expression and for diagnosis and treatment of diseases and conditions associated with expression of DDX36 are provided.

摘要翻译： 提供化合物，组合物和方法用于调节RNAi途径。组合物包含靶向编码EIF2C2的核酸分子的寡核苷酸。提供了使用这些化合物调节RNA干扰以及EIF2C2表达以及用于诊断和治疗与EIF2C2表达相关的疾病的方法。还提供了用于调节DDX36表达的化合物，组合物和方法。组合物包含针对编码DDX36的核酸的寡核苷酸。提供了使用这些化合物调制DDX36表达和用于诊断和治疗与DDX36表达相关的疾病和病症的方法。

2.

发明申请
Compositions and their uses directed to transferases 审中-公开
标题翻译：组合物及其用于转移酶的用途

公开(公告)号：US20050153925A1

公开(公告)日：2005-07-14

申请号：US11013608

申请日：2004-12-16

申请人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Brenda Baker , Donna Ward , William Gaarde , Lex Cowsert , Andrew Watt , Kenneth Dobie

发明人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Brenda Baker , Donna Ward , William Gaarde , Lex Cowsert , Andrew Watt , Kenneth Dobie

IPC分类号： A61K48/00 , C07H21/02 , C12Q1/68

CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/321 , C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of hepatocyte growth factor receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding hepatocyte growth factor receptor. Methods of using these compounds for modulation of hepatocyte growth factor receptor expression and for diagnosis and treatment of disease associated with expression of hepatocyte growth factor receptor are provided.

摘要翻译： 提供化合物，组合物和方法用于调节肝细胞生长因子受体的表达。组合物包含针对编码肝细胞生长因子受体的核酸的寡核苷酸。提供了使用这些化合物调节肝细胞生长因子受体表达和用于诊断和治疗与肝细胞生长因子受体表达相关的疾病的方法。

3.

发明申请
Antisense modulation of sterol regulatory element-binding protein-1 expression 审中-公开
标题翻译：固醇调节元件结合蛋白-1表达的反义调制

公开(公告)号：US20050215504A1

公开(公告)日：2005-09-29

申请号：US11014360

申请日：2004-12-16

申请人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie

发明人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie

IPC分类号： A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68

CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节甾醇调节元件结合蛋白-1的表达。组合物包含靶向编码固醇调节元件结合蛋白-1的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节固醇调节元件结合蛋白-1表达和治疗与甾醇调节元件结合蛋白-1的表达相关的疾病的方法。

4.

发明申请
Antisense modulation of p70 S6 kinase expression 审中-公开
标题翻译： p70 S6激酶表达的反义调制

公开(公告)号：US20050267063A1

公开(公告)日：2005-12-01

申请号：US11117013

申请日：2005-04-27

申请人： C. Bennett , Brett Monia , Susan Freier , Brenda Baker , William Gaarde , Erich Koller , Susan Murray , Andrew Watt , Jacqueline Wyatt , Pamela Nero , Mark Roach , Lex Cowsert , Kenneth Dobie

发明人： C. Bennett , Brett Monia , Susan Freier , Brenda Baker , William Gaarde , Erich Koller , Susan Murray , Andrew Watt , Jacqueline Wyatt , Pamela Nero , Mark Roach , Lex Cowsert , Kenneth Dobie

IPC分类号： A61K38/00 , A61K48/00 , C07H21/04 , C12N5/02 , C12N15/113 , C12N15/85

CPC分类号： C12N15/1137 , A61K38/00 , B23Q2011/0808 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of p70 S6 kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding p70 S6 kinase. Methods of using these compounds for modulation of p70 S6 kinase expression and for treatment of diseases associated with expression of p70 S6 kinase are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节p70 S6激酶的表达。组合物包含靶向编码p70 S6激酶的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节p70 S6激酶表达和治疗与p70 S6激酶表达相关的疾病的方法。

5.

发明申请
Modulation of SLC26A2 expression 审中-公开
标题翻译：调控SLC26A2表达

公开(公告)号：US20060154885A1

公开(公告)日：2006-07-13

申请号：US11072846

申请日：2005-03-04

申请人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes

发明人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes

IPC分类号： A61K48/00 , C07H21/02

CPC分类号： C12N15/1138 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of SLC26A2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SLC26A2. Methods of using these compounds for modulation of SLC26A2 expression and for diagnosis and treatment of disease associated with expression of SLC26A2 are provided.

摘要翻译： 提供化合物，组合物和方法用于调节SLC26A2的表达。组合物包含针对编码SLC26A2的核酸的寡核苷酸。提供了使用这些化合物调节SLC26A2表达和用于诊断和治疗与SLC26A2表达相关的疾病的方法。

6.

发明申请
Antisense modulation of TFAP2C expression 审中-公开
标题翻译： TFAP2C表达的反义调制

公开(公告)号：US20050227938A1

公开(公告)日：2005-10-13

申请号：US11015193

申请日：2004-12-17

申请人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach

发明人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach

IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113

CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/335 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3521 , C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节TFAP2C的表达。组合物包含靶向编码TFAP2C的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节TFAP2C表达和治疗与TFAP2C表达相关的疾病的方法。

7.

发明申请
Antisense modulation of matrix metalloproteinase 1 expression 审中-公开

公开(公告)号：US20060074043A1

公开(公告)日：2006-04-06

申请号：US11250884

申请日：2005-10-13

申请人： Brett Monia , Susan Freier , Sanjay Bhanot , Madeline Butler , Andrew Watt , Jacqueline Wyatt , Brenda Baker , Lex Cowsert , Kenneth Dobie

发明人： Brett Monia , Susan Freier , Sanjay Bhanot , Madeline Butler , Andrew Watt , Jacqueline Wyatt , Brenda Baker , Lex Cowsert , Kenneth Dobie

IPC分类号： A61K48/00 , C07H21/04

CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of matrix metalloproteinase 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding matrix metalloproteinase 1. Methods of using these compounds for modulation of matrix metalloproteinase 1 expression and for treatment of diseases associated with expression of matrix metalloproteinase 1 are provided.

8.

发明申请
Antisense modulation of interferon gamma receptor 2 审中-公开
标题翻译：干扰素γ受体2的反义调制

公开(公告)号：US20050153924A1

公开(公告)日：2005-07-14

申请号：US11013543

申请日：2004-12-15

申请人： C. Bennett , Brett Monia , Susan Murray , Madeline Butler , Nicholas Dean , Rosanne Crooke , Mark Graham , Hong Zhang , Susan Freier , Brenda Baker , Eric Marcusson , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Andrew Watt

发明人： C. Bennett , Brett Monia , Susan Murray , Madeline Butler , Nicholas Dean , Rosanne Crooke , Mark Graham , Hong Zhang , Susan Freier , Brenda Baker , Eric Marcusson , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Andrew Watt

IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68

CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Interferon gamma receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interferon gamma receptor 2. Methods of using these compounds for modulation of Interferon gamma receptor 2 expression and for treatment of diseases associated with expression of Interferon gamma receptor 2 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节干扰素γ受体2的表达。组合物包含靶向编码干扰素γ受体2的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节干扰素γ受体2的方法提供了与干扰素γ受体2表达相关的疾病的表达和治疗。