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1.发明授权Oils enriched with diacylglycerols and phytosterol esters and unit dosage forms thereof for use in therapy 有权富含二酰基甘油和植物甾醇酯的油和其单位剂型用于治疗公开(公告)号：US08507466B2
公开(公告)日：2013-08-13
申请号：US12655240
申请日：2009-12-23
申请人： Dorit Plat , Dori Pelled , Avidor Shulman , Gal Ben-Dror
发明人： Dorit Plat , Dori Pelled , Avidor Shulman , Gal Ben-Dror
CPC分类号： A61K31/22 , A23D9/013 , A23L33/11 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/23 , A61K31/56 , A61K31/575 , A61K45/06 , A61K2300/00 , A23V2250/182 , A23V2250/2136
摘要： Described herein are various lipid mixtures, more particularly special mixtures of fatty acids esters, which may be phytosterol esters and/or glyceride esters. Said mixtures are evaluated in the context of their ability to, upon consumption, affect the levels of circulating LDL and HDL particles, and their therapeutic effect on conditions associated with lipid metabolism, such as atherosclerosis, diabetes, metabolic disorders, etc. Compositions, dietary nutrients, food supplements and nutraceuticals comprising the herein described mixtures are also described.
摘要翻译： 本文描述的是各种脂质混合物，更特别的是脂肪酸酯的特殊混合物，其可以是植物甾醇酯和/或甘油酯。 所述混合物在其消耗后能够影响循环LDL和HDL颗粒的水平及其对与脂质代谢相关的病症（例如动脉粥样硬化，糖尿病，代谢紊乱等）的治疗效果的上下文中进行评估。组合物，饮食 还描述了包含本文所述混合物的营养物，食物补充剂和营养制品。
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2.发明申请Oils enriched with diacylglycerols and phytosterol esters and unit dosage forms thereof for use in therapy 有权富含二酰基甘油和植物甾醇酯的油和其单位剂型用于治疗公开(公告)号：US20100184734A1
公开(公告)日：2010-07-22
申请号：US12655240
申请日：2009-12-23
申请人： Dorit Plat , Dori Pelled , Avidor Shulman , Gal Ben-Dror
发明人： Dorit Plat , Dori Pelled , Avidor Shulman , Gal Ben-Dror
CPC分类号： A61K31/22 , A23D9/013 , A23L33/11 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/23 , A61K31/56 , A61K31/575 , A61K45/06 , A61K2300/00 , A23V2250/182 , A23V2250/2136
摘要： Described herein are various lipid mixtures, more particularly special mixtures of fatty acids esters, which may be phytosterol esters and/or glyceride esters. Said mixtures are evaluated in the context of their ability to, upon consumption, affect the levels of circulating LDL and HDL particles, and their therapeutic effect on conditions associated with lipid metabolism, such as atherosclerosis, diabetes, metabolic disorders, etc. Compositions, dietary nutrients, food supplements and nutraceuticals comprising the herein described mixtures are also described.
摘要翻译： 本文描述的是各种脂质混合物，更特别的是脂肪酸酯的特殊混合物，其可以是植物甾醇酯和/或甘油酯。 所述混合物在其消耗后能够影响循环LDL和HDL颗粒的水平及其对与脂质代谢相关的病症（例如动脉粥样硬化，糖尿病，代谢紊乱等）的治疗效果的上下文中进行评估。组合物，饮食 还描述了包含本文所述混合物的营养物，食物补充剂和营养制品。
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公开(公告)号：US20080085320A1
公开(公告)日：2008-04-10
申请号：US11872440
申请日：2007-10-15
申请人： Gai DROR , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-on , Avidor Shulman , Dori Pelled
发明人： Gai DROR , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-on , Avidor Shulman , Dori Pelled
CPC分类号： A61K31/685 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23V2002/00 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： A lipid preparation including a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidyicholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The preparation possesses an improved bioactivity, and is useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes.
摘要翻译： 包括甘油磷脂或盐的缀合物及其衍生物，特别是磷脂酰丝氨酸（PS），磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰肌醇（PI），磷脂酰甘油（PG）和磷脂酸（PA） - 不饱和脂肪酸（PUFA）酰基，特别是长链多不饱和脂肪酸（LC-PUFA）酰基如ω-3和/或ω-6酰基，其中所述PUFA与所述甘油磷脂共价结合。 该制剂具有改善的生物活性，并且可用于治疗各种认知和精神状况和障碍，并用于维持脑相关系统和过程的正常功能。
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公开(公告)号：US07968112B2
公开(公告)日：2011-06-28
申请号：US11872440
申请日：2007-10-15
申请人： Gai Ben Dror , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
发明人： Gai Ben Dror , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
CPC分类号： A61K31/685 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23V2002/00 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： A lipid preparation including a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidyicholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The preparation possesses an improved bioactivity, and is useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes.
摘要翻译： 包括甘油磷脂或盐的缀合物及其衍生物，特别是磷脂酰丝氨酸（PS），磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰肌醇（PI），磷脂酰甘油（PG）和磷脂酸（PA） - 不饱和脂肪酸（PUFA）酰基，特别是长链多不饱和脂肪酸（LC-PUFA）酰基如ω-3和/或ω-6酰基，其中所述PUFA与所述甘油磷脂共价结合。 该制剂具有改善的生物活性，并且可用于治疗各种认知和精神状况和障碍，并用于维持脑相关系统和过程的正常功能。
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公开(公告)号：US20080085319A1
公开(公告)日：2008-04-10
申请号：US11872258
申请日：2007-10-15
申请人： Gai DROR , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-on , Avidor Shulman , Dori Pelled
发明人： Gai DROR , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-on , Avidor Shulman , Dori Pelled
IPC分类号： A61K31/66 , A23D7/005 , A61K35/00 , A61K35/12 , A61K35/60 , A61K36/00 , A61K36/02 , A61P43/00
CPC分类号： A61K31/685 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23V2002/00 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： A lipid preparation including a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The preparation possesses an improved bioactivity, and is useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes.
摘要翻译： 一种包含甘油磷脂或盐的缀合物及其衍生物，特别是磷脂酰丝氨酸（PS），磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰肌醇（PI），磷脂酰甘油（PG）和磷脂酸（PA） - 不饱和脂肪酸（PUFA）酰基，特别是长链多不饱和脂肪酸（LC-PUFA）酰基如ω-3和/或ω-6酰基，其中所述PUFA与所述甘油磷脂共价结合。 该制剂具有改善的生物活性，并且可用于治疗各种认知和精神状况和障碍，并用于维持脑相关系统和过程的正常功能。
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6.发明授权Glycerophospholipids containing omega-3 and omega-6 fatty acids and their use in the treatment and improvement of cognitive functions 有权含有ω-3和ω-6脂肪酸的甘油磷脂及其在治疗和改善认知功能中的应用公开(公告)号：US08052992B2
公开(公告)日：2011-11-08
申请号：US11414150
申请日：2006-04-28
申请人： Gai Ben Dror , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
发明人： Gai Ben Dror , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
CPC分类号： A21D2/32 , A23D7/011 , A23D7/013 , A23D9/013 , A23K20/158 , A23L33/12 , A23V2002/00 , A61K31/685 , C07F9/106 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： Disclosed herein is a lipid preparation, said preparation comprising a phosphatidylserine moiety, and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. Said lipid preparations are particularly useful in the treatment of mental and cognitive disorders, e.g. ADHD (attention deficit hyperactivity disorder) and Alzheimer's disease.The disclosed preparations present improved bioactivity, and are useful in the treatment of various cognitive and mental conditions and disorders, as well as for maintenance of normal functions of brain-related systems and processes.
摘要翻译： 本文公开了一种脂质制剂，所述制剂包含磷脂酰丝氨酸部分和多不饱和脂肪酸（PUFA）酰基，特别是长链多不饱和脂肪酸（LC-PUFA）酰基，例如ω-3和/或 ω-6酰基，其中所述PUFA与所述甘油磷脂共价结合。 所述脂质制剂特别可用于治疗精神和认知障碍，例如， ADHD（注意缺陷多动障碍）和阿尔茨海默病。 所公开的制剂提供了改善的生物活性，并且可用于治疗各种认知和精神状况和障碍，以及维持脑相关系统和过程的正常功能。
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7.发明申请Glycerophospholipids containing omega-3 and omega-6 fatty acids and their use in the treatment and improvement of cognitive functions 有权含有ω-3和ω-6脂肪酸的甘油磷脂及其在治疗和改善认知功能中的应用公开(公告)号：US20060241080A1
公开(公告)日：2006-10-26
申请号：US11414150
申请日：2006-04-28
申请人： Gai Dror , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
发明人： Gai Dror , Dorit Plat , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled
IPC分类号： A61K31/685 , C07F9/02 , C12P13/00
CPC分类号： A21D2/32 , A23D7/011 , A23D7/013 , A23D9/013 , A23K20/158 , A23L33/12 , A23V2002/00 , A61K31/685 , C07F9/106 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： Disclosed herein is a lipid preparation, said preparation comprising a phosphatidylserine moiety, and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. Said lipid preparations are particularly useful in the treatment of mental and cognitive disorders, e.g. ADHD (attention deficit hyperactivity disorder) and Alzheimer's disease. The disclosed preparations present improved bioactivity, and are useful in the treatment of various cognitive and mental conditions and disorders, as well as for maintenance of normal functions of brain-related systems and processes.
摘要翻译： 本文公开了一种脂质制剂，所述制剂包含磷脂酰丝氨酸部分和多不饱和脂肪酸（PUFA）酰基，特别是长链多不饱和脂肪酸（LC-PUFA）酰基，例如ω-3和/或 ω-6酰基，其中所述PUFA与所述甘油磷脂共价结合。 所述脂质制剂特别可用于治疗精神和认知障碍，例如， ADHD（注意缺陷多动障碍）和阿尔茨海默病。 所公开的制剂提供了改善的生物活性，并且可用于治疗各种认知和精神状况和障碍，以及维持脑相关系统和过程的正常功能。
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公开(公告)号：US08772270B2
公开(公告)日：2014-07-08
申请号：US11673726
申请日：2007-02-12
申请人： Avidor Shulman , Dori Pelled , Tzafra Cohen , Orly Farkash
发明人： Avidor Shulman , Dori Pelled , Tzafra Cohen , Orly Farkash
CPC分类号： A23D9/013 , A23L33/11 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/23 , A61K31/56 , A61K31/575 , A61K2300/00 , A23V2200/332 , A23V2200/3262 , A23V2250/182 , A23V2250/2136
摘要： The invention provides methods for treatment of conditions which require phytosterol therapy without adversely affecting the bioavailability of lipophilic vitamins or lipophilic drugs. The method includes administering a mixture of phytosterol ester(s) (PS-E) and 1,3-diglyceride(s) (DAG) dissolved in an edible oil or fat. The invention also provides a method of improving weight management and a method of treating metabolic conditions that result in overweight. Dietary nutrients, food supplements and food articles containing the mixture are also provided.
摘要翻译： 本发明提供了治疗需要植物甾醇治疗而不会不利地影响亲脂维生素或亲脂性药物的生物利用度的条件的方法。 该方法包括施用溶解在食用油或脂肪中的植物甾醇酯（PS-E）和1,3-二甘油酯（DAG）的混合物。 本发明还提供了改善体重管理的方法和治疗导致超重的代谢病症的方法。 还提供膳食营养素，食品添加剂和含有混合物的食品。
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公开(公告)号：US20090011075A1
公开(公告)日：2009-01-08
申请号：US11912925
申请日：2006-04-27
申请人： Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
发明人： Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
IPC分类号： A23L1/30
CPC分类号： A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要： Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
摘要翻译： 本文公开了包含甘油磷脂如磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰丝氨酸（PS）和磷脂酰肌醇（PI）以及鞘脂如鞘氨醇（SM）的极性脂质混合物。 最重要的是，所述混合物中磷脂的比例与HMF的比例相当，并且由SM> PC> PE> PS> PI或SM = PC> PE> PS> PI表示。 本文还描述了制备所述混合物的方法及其用途。
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公开(公告)号：US20080058415A1
公开(公告)日：2008-03-06
申请号：US10576239
申请日：2004-10-21
申请人： Avidor Shulman , Gai Ben Dror , Dori Pelled
发明人： Avidor Shulman , Gai Ben Dror , Dori Pelled
CPC分类号： A21D2/165 , A23C11/04 , A23D7/001 , A23D9/00 , A23G3/346 , A23G2200/08 , A23G2200/12 , C11C3/08
摘要： Disclosed is a dietary ingredient comprising at least one edible lipid which does not inhibit mineral absorption, enhances mineral absorption and intake, particularly a chemically or enzymatically synthesized synthetic oil, particularly glyceride-based lipid with high levels of mono- or polyunsaturated fatty acids at positions sn-1 and sn-3 of the glycerol backbone, vegetable- and plant-derived oil, such as flax and canola oils, short and medium chains lipid, preferably MCT and an oil mimicking the triglyceride composition of human mother's milk fat and its various uses.The dietary ingredient is particularly intended for use in enhancing calcium absorption and in the prevention and/or treatment of disorders associated with depletion of bone calcium and bone density, prevention and treatment of osteoporosis, for the enhancement of bone formation and bone mass maximization and for the enhancement of bone formation in infants and young children.
摘要翻译： 公开了包含至少一种不抑制矿物质吸收的可食用脂质，增强矿物质吸收和摄入的膳食成分，特别是化学或酶合成的合成油，特别是甘油酯类脂质，其具有高水平的单不饱和脂肪酸或多不饱和脂肪酸 甘油骨架的sn-1和sn-3，植物和植物来源的油，例如亚麻和低芥酸菜子油，短链和中链脂质，优选MCT和模仿人母乳脂肪的甘油三酯组合物的油及其各种 用途。 膳食成分特别用于增强钙的吸收，以及预防和/或治疗与骨钙素和骨密度消耗相关的疾病，预防和治疗骨质疏松症，用于增强骨形成和骨量最大化以及 增强婴幼儿骨骼形成。
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