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    Monoclonal antibody against Interleukin-13 receptor alpha 1 (IL-13Ralpha1)
    3.
    发明申请
    Monoclonal antibody against Interleukin-13 receptor alpha 1 (IL-13Ralpha1) 有权
    白细胞介素-13受体α1单克隆抗体（IL-13Rα1）

    公开(公告)号：US20050058645A1

    公开(公告)日：2005-03-17

    申请号：US10850270

    申请日：2004-05-20

    申请人： Felicity Dunlop ,  Manuel Baca ,  Andrew Nash ,  Louis Fabri ,  Douglas Hilton ,  Nicos Nicola

    发明人： Felicity Dunlop ,  Manuel Baca ,  Andrew Nash ,  Louis Fabri ,  Douglas Hilton ,  Nicos Nicola

    IPC分类号： C07K16/28 ,  C12N5/20 ,  A61K39/395 ,  C07K16/24

    CPC分类号： C07K16/2866 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2319/00

    摘要： The present invention relates generally to antibodies that bind to the Interleukin-13 receptor α1 chain (IL-13Rα1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13Rα1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13Rα1/ligand interaction is also provided.

    摘要翻译： 本发明一般涉及结合白细胞介素-13受体α1链（IL-13Rα1）并通过IL-13和/或IL-4拮抗IL-13受体介导的信号传导的抗体。 更具体地说，本发明为哺乳动物，特别是IL-13Rα1提供人源化或人抗体。 这些抗体在治疗或预防IL-13和/或IL-4介导的疾病或病症中具有应用。 本发明进一步考虑通过施用受试者抗体调节IL-13和/或IL-4介导的疾病或病症的方法。 本发明还提供了可用于鉴定通过IL-13受体复合物调节IL-13和/或IL-4信号传导的抗体或其它试剂的测定系统。 因此，还提供了筛选IL-13Rα1/配体相互作用的调节剂的方法。

    Methods of regulating cytokine signalling
    4.
    发明申请
    Methods of regulating cytokine signalling 审中-公开
    调节细胞因子信号传导的方法

    公开(公告)号：US20080057517A1

    公开(公告)日：2008-03-06

    申请号：US11818589

    申请日：2007-06-15

    申请人： Sandra Nicholson ,  Manuel Baca ,  Nicos Nicola ,  Douglas Hilton ,  Jian Zhang ,  Louis Fabri ,  Andrew Nash

    发明人： Sandra Nicholson ,  Manuel Baca ,  Nicos Nicola ,  Douglas Hilton ,  Jian Zhang ,  Louis Fabri ,  Andrew Nash

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6863

    摘要： The present invention relates generally to a method for regulating cytokine signalling and agents useful for same. The method of the present invention is predicated in part on the identification of the molecular target of suppressor of cytokine signalling (SOCS) interaction in controlling cytokine signalling. The identification of the molecular target permits the development of assays to screen for a range of agonists and antagonists useful in modulating cytokine function. The present invention further provides, therefore, screening assays and more particularly high through-put screening assays for agonists and antagonists of SOCS-receptor interaction. Such agonists and antagonists are useful in the manufacture of medicaments for controlling cytokine signalling. Control of cytokine signalling is important for the treatment of a range of conditions including cancer, inflammatory conditions, immunological disorders and any other conditions involving aberrations of signal transduction.

    摘要翻译： 本发明一般涉及用于调节细胞因子信号传导的方法和可用于其的试剂。 本发明的方法部分地基于在控制细胞因子信号传导中识别细胞因子信号传导抑制剂（SOCS）相互作用的分子靶标。 分子靶标的鉴定允许开发测定以筛选可用于调节细胞因子功能的一系列激动剂和拮抗剂。 因此，本发明进一步提供用于SOCS-受体相互作用的激动剂和拮抗剂的筛选测定和更特别的高通量筛选测定。 这样的激动剂和拮抗剂可用于制备用于控制细胞因子信号传导的药物。 细胞因子信号传导的控制对于治疗一系列病症（包括癌症，炎性病症，免疫学障碍和涉及信号转导异常的任何其他病症）是重要的。

    Methods of Identifying Compounds Which Modulate Granulocite-Colony Stimulating Factor (G-Csf) Dependent Processes by Modulation of the Levels of Suppressor of Cytokine Signaling (Socs)
    8.
    发明申请
    Methods of Identifying Compounds Which Modulate Granulocite-Colony Stimulating Factor (G-Csf) Dependent Processes by Modulation of the Levels of Suppressor of Cytokine Signaling (Socs) 审中-公开
    通过调节细胞因子信号抑制因子水平鉴定化合物的方法，调节粒细胞集落刺激因子（G-Csf）依赖过程

    公开(公告)号：US20070275916A1

    公开(公告)日：2007-11-29

    申请号：US10559711

    申请日：2004-06-04

    申请人： Ben Croker ,  Andrew Roberts ,  Don Metcalf ,  Warren Alexander ,  Doug Hilton ,  Nicos Nicola

    发明人： Ben Croker ,  Andrew Roberts ,  Don Metcalf ,  Warren Alexander ,  Doug Hilton ,  Nicos Nicola

    IPC分类号： A61K48/00 ,  A01K67/00 ,  C07H21/04 ,  C07K1/00

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2267/0381 ,  C07K14/4703 ,  C12N2800/30 ,  C12N2830/008

    摘要： The present invention relates generally to compounds which modulate cytokine-dependent processes. More particularly, the compounds of the present invention modulate responses to a colony stimulating factor and even more particularly to granulocyte-colony stimulating factor (G-CSF) by modulating the levels of molecules which inhibit G-CSF such as but not limited to a suppressor of cytokine signaling (SOCS) and in particular SOCS-3. The present invention further contemplates methods for regulating G-CSF-dependent processes by contacting cells in vitro with or administering to a subject a compound which up- or down-regulates the level of activity of G-CSF by modulating the level or activity of a SOCS molecule such as SOCS-3. The instant compounds are further useful for modulating a range of G-CSF-induced cellular responses including neutrophil recovery after chemotherapy or radiotherapy, mobilizing stem and progenitor cells, treating infection and treating inflammatory conditions.

    摘要翻译： 本发明一般涉及调节细胞因子依赖性过程的化合物。 更具体地，本发明的化合物通过调节抑制G-CSF的分子的水平来调节对集落刺激因子的反应，甚至更特别地调节粒细胞集落刺激因子（G-CSF），例如但不限于抑制因子 的细胞因子信号（SOCS），特别是SOCS-3。 本发明进一步考虑了通过使细胞在体外与受试者接触的方法来调节G-CSF依赖性过程的方法，所述化合物通过调节G-CSF的水平或活性来上调或下调G-CSF的活性水平 SOCS分子如SOCS-3。 本发明化合物还可用于调节一系列G-CSF诱导的细胞反应，包括化疗或放疗后的嗜中性粒细胞回收，动员干细胞和祖细胞，治疗感染和治疗炎性病症。

    Structure of SOCS and uses thereof
    9.
    发明申请
    Structure of SOCS and uses thereof 有权
    SOCS的结构及其用途

    公开(公告)号：US20070179089A1

    公开(公告)日：2007-08-02

    申请号：US11598212

    申请日：2006-11-09

    申请人： Raymond Norton ,  Jeffrey Babon ,  Sandra Nicholson ,  Nicos Nicola ,  Edward McManus ,  Manuel Baca ,  Shenggen Yao

    发明人： Raymond Norton ,  Jeffrey Babon ,  Sandra Nicholson ,  Nicos Nicola ,  Edward McManus ,  Manuel Baca ,  Shenggen Yao

    IPC分类号： A61K48/00 ,  C07K14/705 ,  A61K38/17 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/4703 ,  A61K38/17

    摘要： The present invention relates to the identification of a PEST motif in Suppressor of Cytokine Signalling (SOCS) proteins, the deletion/inactivation of which has been found to increase the stability of the protein whilst maintaining at least one biological activity of the protein. Such SOCS proteins with deleted/inactivated PEST motifs can be used in gene and protein therapy procedures to provide a more stable SOCS protein when compared to the native protein. The present invention also relates to the characterization of the structure of SOCS proteins, and methods of using this structural information to identify compounds which modulate the activity of SOCS.

    摘要翻译： 本发明涉及鉴定细胞因子信号传导抑制因子（SOCS）蛋白质的抑制因子的PEST基序，已经发现其缺失/失活增加了蛋白质的稳定性，同时保持蛋白质的至少一种生物学活性。 具有缺失/失活的PEST基序的这种SOCS蛋白质可用于基因和蛋白质治疗程序，以便与天然蛋白质相比提供更稳定的SOCS蛋白质。 本发明还涉及SOCS蛋白质结构的表征，以及使用该结构信息鉴定调节SOCS活性的化合物的方法。