公开(公告)号：US20080171061A1

公开(公告)日：2008-07-17

申请号：US11880126

申请日：2007-07-19

申请人： Douglas Nixon ,  Keith Garrison ,  Duncan Meiklejohn ,  Mario Ostrowski ,  R. Bradley Jones ,  Ashish Agrawal ,  Jack Lenz ,  Seth Rakoff-Nahoum ,  Frederick M. Hecht

发明人： Douglas Nixon ,  Keith Garrison ,  Duncan Meiklejohn ,  Mario Ostrowski ,  R. Bradley Jones ,  Ashish Agrawal ,  Jack Lenz ,  Seth Rakoff-Nahoum ,  Frederick M. Hecht

IPC分类号： A61K39/21 ,  A61K31/70 ,  C07K16/00 ,  C12N5/00

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55583 ,  C12N2740/16034

摘要： The present invention provides isolated HERV polypeptides; and compositions, including immunogenic compositions, comprising a HERV polypeptide. The present invention provides immunogenic compositions comprising a nucleic acid comprising a nucleotide sequence encoding a HERV polypeptide. The immunogenic compositions are useful for stimulating a T cell immune response to a lentiviral peptide. The present invention further provides methods of stimulating an immune response in an individual to a retrovirus- or lentivirus-infected cell. The present invention further provides methods of treating cancers in which HERV polypeptides are expressed. Also provided are methods of treating disorders, involving decreasing an immune response to a HERV polypeptide.

摘要翻译： 本发明提供了分离的HERV多肽; 和包含HERV多肽的组合物，包括免疫原性组合物。 本发明提供了包含含有编码HERV多肽的核苷酸序列的核酸的免疫原性组合物。 免疫原性组合物可用于刺激对慢病毒肽的T细胞免疫应答。 本发明还提供刺激个体对逆转录病毒或慢病毒感染细胞的免疫应答的方法。 本发明还提供了治疗其中表达HERV多肽的癌症的方法。 还提供了治疗疾病的方法，涉及降低对HERV多肽的免疫应答。

公开(公告)号：US20110046042A1

公开(公告)日：2011-02-24

申请号：US12677278

申请日：2008-09-19

申请人： Douglas F. Nixon ,  Keith Garrison ,  Duncan Meiklejohn ,  Mario Ostrowski ,  R. Bradley Jones ,  Ashish Agrawal ,  Frederick M. Hecht

发明人： Douglas F. Nixon ,  Keith Garrison ,  Duncan Meiklejohn ,  Mario Ostrowski ,  R. Bradley Jones ,  Ashish Agrawal ,  Frederick M. Hecht

IPC分类号： A61K38/08 ,  C07K7/06 ,  C07H21/04 ,  C07K7/08 ,  A61P31/18 ,  C12N15/63 ,  A61K31/7088 ,  A61K38/10 ,  C12Q1/02 ,  A61P35/00 ,  A61P31/12

CPC分类号： C07K14/47 ,  A61K39/0005 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/55 ,  A61K2039/57 ,  C12N2740/16011 ,  G01N33/5047 ,  G01N2333/15 ,  G01N2333/52

摘要： The present invention provides LINE polypeptides; and compositions, including immunogenic compositions, comprising a subject LINE polypeptide. The present invention provides a recombinant nucleic acid comprising a nucleotide sequence encoding a subject LINE polypeptide. A subject composition is useful for stimulating a T-cell immune response to a LINE peptide. The present invention further provides methods of stimulating an immune response in an individual to a retrovirus- or lentivirus-infected cell. The present invention further provides methods of treating cancers that are associated with tissues in which LINE polypeptides are aberrantly expressed. Also provided are methods of treating disorders, involving decreasing an immune response to a LINE polypeptide.

摘要翻译： 本发明提供LINE多肽; 和包含免疫原性组合物的组合物，其包含受试者LINE多肽。 本发明提供了包含编码受试者LINE多肽的核苷酸序列的重组核酸。 主题组合物可用于刺激对LINE肽的T细胞免疫应答。 本发明还提供刺激个体对逆转录病毒或慢病毒感染细胞的免疫应答的方法。 本发明还提供了治疗与LINE多肽异常表达的组织相关的癌症的方法。 还提供了治疗疾病的方法，涉及降低对LINE多肽的免疫应答。