公开(公告)号：US08709385B2

公开(公告)日：2014-04-29

申请号：US12836444

申请日：2010-07-14

申请人： Dov Tamarkin ,  Alex Besonov ,  Tal Berman ,  David Schuz ,  Elana Gazal

发明人： Dov Tamarkin ,  Alex Besonov ,  Tal Berman ,  David Schuz ,  Elana Gazal

IPC分类号： A61K8/00 ,  A61K8/02 ,  A61K9/00 ,  A61K9/12 ,  A61K31/00 ,  A61K31/60 ,  A61P17/00 ,  A61P31/00 ,  A61P29/00

CPC分类号： A61K9/122 ,  A61K8/046 ,  A61K8/90 ,  A61K9/06 ,  A61K9/107 ,  A61K31/19 ,  A61K31/196 ,  A61K31/506 ,  A61K31/522 ,  A61K31/60 ,  A61K31/7056 ,  A61K47/10 ,  A61K47/36 ,  A61Q19/00

摘要： Pharmaceutical or cosmetic compositions and methods for their use are provided comprising water and a surfactant polymer system comprising a Poloxamer at a concentration of about 0.1% to about 15% by weight; wherein when the Poloxamer is between about 0.1% to about 5% Poloxamer. The composition can further comprise a supporting agent comprising a non-ionic surface active agent or a supporting agent comprising a non surfactant polymer or polysaccharide and an active agent, where the Poloxamer is capable of fixing the composition on delivery to a body surface. There are further provided therapeutic cell compositions and their uses.

摘要翻译： 提供了用于其使用的药物或化妆品组合物和方法，其包含水和表面活性剂聚合物体系，其包含浓度为约0.1重量％至约15重量％的泊洛沙姆; 其中当泊洛沙姆为约0.1％至约5％泊洛沙姆时。 组合物还可以包含含有非离子表面活性剂或包含非表面活性剂聚合物或多糖和活性剂的支持剂的支持剂，其中泊洛沙姆能够将组合物在输送到身体表面时固定。 还提供治疗细胞组合物及其用途。

公开(公告)号：US20110008266A1

公开(公告)日：2011-01-13

申请号：US12836444

申请日：2010-07-14

申请人： Dov Tamarkin ,  Alex Besonov ,  Tal Berman ,  David Schuz ,  Elana Gazal

发明人： Dov Tamarkin ,  Alex Besonov ,  Tal Berman ,  David Schuz ,  Elana Gazal

IPC分类号： A61K9/12 ,  A61K47/34 ,  A61K31/197 ,  A61P29/00 ,  A61K31/60 ,  A61K31/7028 ,  A61P31/00 ,  A61K31/522 ,  A61K31/506 ,  A61K31/327 ,  A61K35/12

CPC分类号： A61K9/122 ,  A61K8/046 ,  A61K8/90 ,  A61K9/06 ,  A61K9/107 ,  A61K31/19 ,  A61K31/196 ,  A61K31/506 ,  A61K31/522 ,  A61K31/60 ,  A61K31/7056 ,  A61K47/10 ,  A61K47/36 ,  A61Q19/00

摘要： Pharmaceutical or cosmetic compositions and methods for their use are provided comprising water and a surfactant polymer system comprising a Poloxamer at a concentration of about 0.1% to about 15% by weight; wherein when the Poloxamer is between about 0.1% to about 5% Poloxamer. The composition can further comprise a supporting agent comprising a non-ionic surface active agent or a supporting agent comprising a non surfactant polymer or polysaccharide and an active agent, where the Poloxamer is capable of fixing the composition on delivery to a body surface. There are further provided therapeutic cell compositions and their uses.

摘要翻译： 提供了用于其使用的药物或化妆品组合物和方法，其包含水和表面活性剂聚合物体系，其包含浓度为约0.1重量％至约15重量％的泊洛沙姆; 其中当泊洛沙姆为约0.1％至约5％泊洛沙姆时。 组合物还可以包含含有非离子表面活性剂或包含非表面活性剂聚合物或多糖和活性剂的支持剂的支持剂，其中泊洛沙姆能够将组合物在输送到身体表面时固定。 还提供治疗细胞组合物及其用途。

公开(公告)号：US20080299220A1

公开(公告)日：2008-12-04

申请号：US12014088

申请日：2008-01-14

申请人： Dov Tamarkin ,  Meir Eini ,  Doron Friedman ,  Alex Besonov ,  David Schuz ,  Tal Berman ,  Jorge Danziger ,  Rita Keynan ,  Ella Zlatkis

发明人： Dov Tamarkin ,  Meir Eini ,  Doron Friedman ,  Alex Besonov ,  David Schuz ,  Tal Berman ,  Jorge Danziger ,  Rita Keynan ,  Ella Zlatkis

IPC分类号： A61K33/00 ,  A61K47/34 ,  A61K31/375 ,  A61K31/355 ,  A61K31/351 ,  A61K31/4412 ,  A61K31/047 ,  A61K31/57 ,  A61K9/12 ,  A61K31/522 ,  A61K31/135

CPC分类号： A61K9/12 ,  A01N25/02 ,  A01N25/16 ,  A61K9/0014 ,  A61K9/122 ,  A61K31/047 ,  A61K31/135 ,  A61K31/351 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4412 ,  A61K31/522 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38

摘要： A waterless composition suitable for delivery of an active agent to a body surface or cavity includes a vehicle having about 70% to about 99% by weight of a hydrophilic polar solvent, said hydrophilic solvent selected from the group consisting of (i) a mixture of two or more different polyethylene glycols (PEGs), wherein at least one PEG is a high molecular weight PEG having a melting point greater than 25° C.; and (ii) propylene glycol (PG); about 0% to about 10% of at least one surface active agent; about 0% to about 5% of a polymeric agent; about 0% to about 30% of a secondary hydrophilic solvent; and about 0% to about 5% of a silicone oil; and about 3% to about 25% hydrophobic propellant. The composition is otherwise substantially free of a hydrophobic solvent and includes at least one of a surface active agent and a polymeric agent. The vehicle and the propellant are sufficiently miscible that the components may be homogeneously distributed with mild shaking.

摘要翻译： 适用于将活性剂递送到体表或空腔的无水组合物包括具有约70％至约99％重量的亲水极性溶剂的载体，所述亲水性溶剂选自（i） 两种或更多种不同的聚乙二醇（PEG），其中至少一种PEG是熔点大于25℃的高分子量PEG; 和（ii）丙二醇（PG）; 约0％至约10％的至少一种表面活性剂; 约0％至约5％的聚合物; 约0％至约30％的第二亲水溶剂; 和约0％至约5％的硅油; 和约3％至约25％的疏水性推进剂。 组合物基本上不含疏水性溶剂，并且包括表面活性剂和聚合物剂中的至少一种。 车辆和推进剂是充分混溶的，这些组分可以均匀分布，温和摇动。

公开(公告)号：US20070292461A1

公开(公告)日：2007-12-20

申请号：US11653205

申请日：2007-01-12

申请人： Dov Tamarkin ,  Doron Friedman ,  Meir Eini ,  Alex Besonov ,  Jorge Danziger ,  David Schuz ,  Tal Berman

发明人： Dov Tamarkin ,  Doron Friedman ,  Meir Eini ,  Alex Besonov ,  Jorge Danziger ,  David Schuz ,  Tal Berman

IPC分类号： A61K8/02 ,  A61P17/12 ,  A61P23/02 ,  A61P3/02 ,  A61P31/00 ,  A61P31/12 ,  A61P35/00 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08

CPC分类号： A61K8/86 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0046 ,  A61K9/122 ,  A61K2800/5422 ,  A61Q17/04 ,  A61Q19/007 ,  A61Q19/04 ,  A61Q19/08 ,  A61Q19/10

摘要： The invention relates to stable pharmaceutical or cosmetic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent comprising polyethylene glycol (PEG) or PEG derivative and mixtures thereof, or comprising propylene glycol, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition.

摘要翻译： 本发明涉及含有某些活性剂的稳定的药物或化妆品泡沫组合物，具有独特的治疗性质和使用这种组合物的治疗方法。 可发泡组合物包括至少一种包含聚乙二醇（PEG）或PEG衍生物及其混合物或包含丙二醇的溶剂，其中溶剂的浓度为总组合物重量的约70％至约96.5％，在 至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％。

公开(公告)号：US08486374B2

公开(公告)日：2013-07-16

申请号：US12014088

申请日：2008-01-14

申请人： Dov Tamarkin ,  Meir Eini ,  Doron Friedman ,  Alex Besonov ,  David Schuz ,  Tal Berman ,  Jorge Danziger ,  Rita Keynan ,  Ella Zlatkis

发明人： Dov Tamarkin ,  Meir Eini ,  Doron Friedman ,  Alex Besonov ,  David Schuz ,  Tal Berman ,  Jorge Danziger ,  Rita Keynan ,  Ella Zlatkis

IPC分类号： A61K33/00 ,  A61K47/34 ,  A61K31/375 ,  A61K31/355 ,  A61K31/351 ,  A61K31/4412 ,  A61K31/47 ,  A61K31/57 ,  A61K9/12 ,  A61K31/522 ,  A61K31/135 ,  A61K31/00

CPC分类号： A61K9/12 ,  A01N25/02 ,  A01N25/16 ,  A61K9/0014 ,  A61K9/122 ,  A61K31/047 ,  A61K31/135 ,  A61K31/351 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4412 ,  A61K31/522 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38

摘要： A waterless composition suitable for delivery of an active agent to a body surface or cavity includes a vehicle having about 70% to about 99% by weight of a hydrophilic polar solvent, said hydrophilic solvent selected from the group consisting of (i) a mixture of two or more different polyethylene glycols (PEGs), wherein at least one PEG is a high molecular weight PEG having a melting point greater than 25° C.; and (ii) propylene glycol (PG); about 0% to about 10% of at least one surface active agent; about 0% to about 5% of a polymeric agent; about 0% to about 30% of a secondary hydrophilic solvent; and about 0% to about 5% of a silicone oil; and about 3% to about 25% hydrophobic propellant. The composition is otherwise substantially free of a hydrophobic solvent and includes at least one of a surface active agent and a polymeric agent. The vehicle and the propellant are sufficiently miscible that the components may be homogeneously distributed with mild shaking.

摘要翻译： 适用于将活性剂递送到体表或空腔的无水组合物包括具有约70％至约99％重量的亲水极性溶剂的载体，所述亲水性溶剂选自（i） 两种或更多种不同的聚乙二醇（PEG），其中至少一种PEG是熔点大于25℃的高分子量PEG; 和（ii）丙二醇（PG）; 约0％至约10％的至少一种表面活性剂; 约0％至约5％的聚合物; 约0％至约30％的第二亲水溶剂; 和约0％至约5％的硅油; 和约3％至约25％的疏水性推进剂。 组合物基本上不含疏水性溶剂，并且包括表面活性剂和聚合物剂中的至少一种。 车辆和推进剂是充分混溶的，这些组分可以均匀分布，温和摇动。

公开(公告)号：US20080063607A1

公开(公告)日：2008-03-13

申请号：US11894798

申请日：2007-08-20

申请人： Dov Tamarkin ,  Doron Friedman ,  Meir Eini ,  Alex Besonov ,  Jorge Danziger ,  David Schuz ,  Tal Berman

发明人： Dov Tamarkin ,  Doron Friedman ,  Meir Eini ,  Alex Besonov ,  Jorge Danziger ,  David Schuz ,  Tal Berman

IPC分类号： A61K9/12 ,  A61K47/00 ,  A61P17/00

CPC分类号： A61K8/86 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0046 ,  A61K9/122 ,  A61K2800/5422 ,  A61Q17/04 ,  A61Q19/007 ,  A61Q19/04 ,  A61Q19/08 ,  A61Q19/10

摘要： The invention relates to stable pharmaceutical or cosmetic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent comprising polyethylene glycol (PEG) or PEG derivative and mixtures thereof, or comprising propylene glycol, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition.

摘要翻译： 本发明涉及含有某些活性剂的稳定的药物或化妆品泡沫组合物，具有独特的治疗性质和使用这种组合物的治疗方法。 可发泡组合物包括至少一种包含聚乙二醇（PEG）或PEG衍生物及其混合物或包含丙二醇的溶剂，其中溶剂的浓度为总组合物重量的约70％至约96.5％，在 至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％。

公开(公告)号：US10117812B2

公开(公告)日：2018-11-06

申请号：US11488989

申请日：2006-07-19

申请人： Dov Tamarkin ,  Doron Friedman ,  Meir Eini ,  Alex Besonov

发明人： Dov Tamarkin ,  Doron Friedman ,  Meir Eini ,  Alex Besonov

IPC分类号： A61K8/04 ,  A61K47/14 ,  A61K47/22 ,  A61K8/49 ,  A61K8/06 ,  A61K8/31 ,  A61K8/37 ,  A61K9/00 ,  A61K9/107 ,  A61K9/12 ,  A61Q19/00 ,  A01N25/16 ,  A61K8/96 ,  A61K35/04 ,  A61K47/06 ,  A61K47/10 ,  A61K8/73 ,  A61K8/81 ,  A61K47/32 ,  A61K47/38 ,  A61Q19/02 ,  A61Q19/08

摘要： The present invention relates to a foamable vehicle or cosmetic or pharmaceutical composition, comprising: (1) an organic carrier, at a concentration of 10% to 70% by weight, wherein said organic carrier concurrently comprises: (i) at least one hydrophobic organic carrier, and (ii) at least one polar solvent; (2) at least one surface-active agent; (3) water; and (4) at least one liquefied or compressed gas propellant at a concentration of 3% to 25% by weight of the total composition.The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.

公开(公告)号：US09622947B2

公开(公告)日：2017-04-18

申请号：US12350854

申请日：2009-01-08

申请人： Dov Tamarkin ,  Doron Friedman ,  Meir Eini ,  Alex Besonov

发明人： Dov Tamarkin ,  Doron Friedman ,  Meir Eini ,  Alex Besonov

IPC分类号： A61K8/04 ,  A61K8/96 ,  A61K47/14 ,  A61K47/06 ,  A61K47/10 ,  A61K9/00 ,  A61K35/04 ,  A61K9/12 ,  A61K8/37 ,  A61K8/31 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  A01N25/16

CPC分类号： A61K8/046 ,  A01N25/16 ,  A61K8/062 ,  A61K8/31 ,  A61K8/37 ,  A61K8/375 ,  A61K8/4973 ,  A61K8/731 ,  A61K8/8176 ,  A61K8/965 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/122 ,  A61K35/04 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/32 ,  A61K47/38 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08

摘要： The present invention relates to a foamable vehicle or cosmetic or pharmaceutical composition, comprising: (1) an organic carrier, at a concentration of 10% to 70% by weight, wherein said organic carrier concurrently comprises: (i) at least one hydrophobic organic carrier, and (ii) at least one polar solvent; (2) at least one surface-active agent; (3) water; and (4) at least one liquefied or compressed gas propellant at a concentration of 3% to 25% by weight of the total composition.The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.

公开(公告)号：US08362091B2

公开(公告)日：2013-01-29

申请号：US12767511

申请日：2010-04-26

申请人： Dov Tamarkin ,  Doron Friedman ,  Meir Eini ,  Alex Besonov

发明人： Dov Tamarkin ,  Doron Friedman ,  Meir Eini ,  Alex Besonov

IPC分类号： A01N25/16 ,  A61K47/00 ,  A61K47/30 ,  A61K47/32

CPC分类号： A61K47/10 ,  A01N25/16 ,  A61K8/046 ,  A61K9/0014 ,  A61K9/0034 ,  A61K9/12 ,  A61K9/122 ,  A61K47/14 ,  A61K47/38 ,  A61Q19/00 ,  Y10S514/945 ,  A01N53/00

摘要： A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

摘要翻译： 吸湿性药物组合物包括至少一种浓度足以提供至少0.9的Aw值的吸湿物质和抗感染剂。 起泡药物载体包括约50％至约98％的选自多元醇和PEG的极性溶剂; 0％至约48％的第二极性溶剂; 约0.2重量％至约5重量％的表面活性剂; 约0.01重量％至约5重量％的至少一种聚合物; 和以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

公开(公告)号：US07820145B2

公开(公告)日：2010-10-26

申请号：US10835505

申请日：2004-04-28

申请人： Dov Tamarkin ,  Doron Friedman ,  Meir Eini ,  Alex Besonov

发明人： Dov Tamarkin ,  Doron Friedman ,  Meir Eini ,  Alex Besonov

IPC分类号： A61K9/12

CPC分类号： A61K9/122 ,  A01N25/16 ,  A61K8/046 ,  A61K9/0034 ,  A61K9/107 ,  A61K9/12 ,  A61K31/351 ,  A61K31/436 ,  A61K31/496 ,  A61K31/522 ,  A61K31/573 ,  A61K38/13 ,  A61K47/10 ,  A61K47/14 ,  A61Q19/00

摘要： The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.

摘要翻译： 本发明涉及含有某些活性剂的稳定的含油化妆品或治疗性泡沫组合物，其具有独特的治疗性质和使用这种组合物的治疗方法。 可发泡组合物包括至少一种选自疏水性溶剂，硅油，软化剂，​​共溶剂及其混合物的溶剂，其中溶剂的浓度为约70重量％至约96.5重量％ 总组合物，至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％; 浓度为总组合物重量的约0.1％至约5％的至少一种胶凝剂; 治疗有效量的至少一种活性剂; 和至少一种液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。