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    Method of delivering PESP/ICC as well as adjusting the refractory period of the heart
    1.
    发明授权
    Method of delivering PESP/ICC as well as adjusting the refractory period of the heart 有权
    提供PESP / ICC的方法以及调整心脏的不应期

    公开(公告)号：US08046064B2

    公开(公告)日：2011-10-25

    申请号：US11379892

    申请日：2006-04-24

    申请人： Dwight H. Warkentin ,  D. Curtis Deno

    发明人： Dwight H. Warkentin ,  D. Curtis Deno

    IPC分类号： A61N1/39

    CPC分类号： A61N1/3627 ,  A61N1/36014 ,  A61N1/36114 ,  A61N1/36514 ,  A61N1/36585 ,  A61N1/368

    摘要： Medical devices and methods are used to treat cardiac dysfunction conditions which involve delivery of stimulation pulses in cardiac refractory periods in order to modulate an effective refractory period (ERP). Such devices and methods may be used in conjunction with or in place of other therapies, including increased cardiac contractility (ICC) therapy, post extrasystolic potentiation (PESP) therapy, and other therapies to achieve increased heart contractility, provide a safer and more effective regimen for the corresponding stimulation therapies, and reduce the risk of inducing an arrhythmia.

    摘要翻译： 医疗器械和方法被用于治疗心脏功能障碍状况，其涉及在心脏不应期内输送刺激脉冲以调节有效的不应期（ERP）。 这些装置和方法可以与其他疗法结合使用或替代其它疗法，包括增加心肌收缩力（ICC）治疗，收缩后增强疗法（PESP）疗法和其他疗法以达到增加的心脏收缩力，提供更安全和更有效的方案 用于相应的刺激疗法，并降低引起心律失常的风险。

    Communications system for an implantable device and a drug dispenser
    2.
    发明授权
    Communications system for an implantable device and a drug dispenser 有权
    用于可植入装置和药物分配器的通信系统

    公开(公告)号：US06824512B2

    公开(公告)日：2004-11-30

    申请号：US10123958

    申请日：2002-04-17

    申请人： Dwight H. Warkentin ,  Bozidar Ferek-Petric

    发明人： Dwight H. Warkentin ,  Bozidar Ferek-Petric

    IPC分类号： A61B500

    CPC分类号： A61N1/37282 ,  A61N1/08 ,  Y10S128/903 ,  Y10S128/904 ,  Y10S128/92

    摘要： A closed loop system for monitoring drug dose, intake and effectiveness includes a pill dispenser in data communications with at least one implantable medical device. The system is preferably implemented in a web-enabled environment in which a remote data center communicates with the implantable devices (IMDs) in a patient via a programmer or the pill dispenser. Th data center includes high speed computers and databases relating to patient history and device information. A physician or clinician may access the remote data center to review and monitor the IMDs remotely. More specifically, the IMDs are adapted to chronically monitor the pill dispenser to thereby log and document drug dose, patient compliance with prescriptive regimens and as well to monitor drug efficacy in the patient. The system further provides a dynamic drug management system, compatible with a web-enabled interactive data communication environment, that accurately monitors dose and specific drug effectiveness in a patient to enhance patient care.

    摘要翻译： 用于监测药物剂量，摄入量和有效性的闭环系统包括与至少一个可植入医疗装置的数据通信中的药丸分配器。 该系统优选地在web启用的环境中实现，其中远程数据中心通过编程器或药丸分配器与患者中的可植入装置（IMD）通信。 数据中心包括与病历和设备信息相关的高速计算机和数据库。 医生或临床医生可以访问远程数据中心以远程审查和监视IMD。 更具体地，IMD适于长期监测药丸分配器，从而记录和记录药物剂量，患者对规定方案的依从性以及监测患者的药物功效。 该系统进一步提供了一种动态药物管理系统，与能够准确地监测患者剂量和特异性药物效力的网络互动数据通信环境兼容以增强患者护理。

    Multi-site ventricular pacing system measuring QRS duration
    3.
    发明授权
    Multi-site ventricular pacing system measuring QRS duration 有权
    多站点心室起搏系统测量QRS持续时间

    公开(公告)号：US06804555B2

    公开(公告)日：2004-10-12

    申请号：US09896281

    申请日：2001-06-29

    申请人： Dwight H. Warkentin

    发明人： Dwight H. Warkentin

    IPC分类号： A61N1368

    CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： Bi-Ventricular or AV synchronous cardiac pacing systems that pace and sense in at least one atrial heart chamber and deliver ventricular pacing pulses to right ventricular (RV) and left ventricular (LV) sites separated by a V—V delay for treatment of heart failure are disclosed that optimize one or more of the AV delay and V—V delay to enhance left ventricular filling and cardiac output as a function of QRS duration. A system and method for monitoring the QRS duration, processing such signals to provide data from which the onset or progression of heart failure is determined, and adjusting synchronous pacing delay parameters including SAV delay and/or PAV delay and/or V—V delay to enhance cardiac output as a function of QRS duration is provided. The SAV, PAV, and/or the V—V delays can be varied from the prevailing delays as a function of measured QRS duration so as to minimize the width of the QRS complex.

    摘要翻译： 公开了双心室或AV同步心脏起搏系统，其在至少一个心房室中起搏和感觉，并将心室起搏脉冲输送到通过VV延迟分离用于治疗心力衰竭的右心室（RV）和左心室（LV）部位。 优化AV延迟和VV延迟中的一个或多个以增强作为QRS持续时间的函数的左心室充盈和心输出量的系统和方法。用于监测QRS持续时间的系统和方法，处理这些信号以提供来自其的起始或进展的数据 确定了心力衰竭，并且提供了包括SAV延迟和/或PAV延迟和/或VV延迟的同步起搏延迟参数，以增强作为QRS持续时间的函数的心输出量。 SAV，PAV和/或V-V延迟可以从作为测量QRS持续时间的函数的主要延迟变化，以便使QRS复合体的宽度最小化。

    Mechanically-based interval optimization for a biventricular pacing engine
    6.
    发明授权
    Mechanically-based interval optimization for a biventricular pacing engine 失效
    用于双心室起搏引擎的基于机械的间隔优化

    公开(公告)号：US07027866B2

    公开(公告)日：2006-04-11

    申请号：US10629075

    申请日：2003-07-29

    申请人： Dwight H. Warkentin

    发明人： Dwight H. Warkentin

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

    摘要： According to the present invention, discrete measurements of fluid pressure development (and derivatives thereof) are used in optimizing hemodynamics for cardiac resynchronization therapy (CRT) delivery and multiple chamber cardiac pacing, and in enhancing hemodynamics in the event of a sub-optimal left-side lead placement. For example, such diverse pressure measurements include: maximum positive or negative dP/dt values, ePAD, RV systolic, RV diastolic, pulse pressure, and the like. According to the present invention, on a periodic basis or upon demand one or more cardiac pacing intervals are iteratively cycled through a predetermined range and the resulting pressure measurements stored for comparison. The cardiac pacing intervals are then adjusted based at least in part upon the most appropriate, or desirable, measured hemodynamics of the patient. The present invention may be implemented as computer readable instructions executed by a microprocessor-based implantable medical device.

    摘要翻译： 根据本发明，流体压力发展（及其衍生物）的离散测量用于优化用于心脏再同步治疗（CRT）递送和多室心脏起搏的血液动力学，并且在用于增强血液动力学的情况下， 侧排位置。 例如，这种不同的压力测量包括：最大正或负dP / dt值，ePAD，RV收缩压，RV舒张压，脉压等。 根据本发明，周期性地或根据需要，一个或多个心脏起搏间隔在预定范围内迭代循环，并且将所得到的压力测量值存储用于比较。 然后至少部分地基于最合适的或期望的测量的患者的血液动力学来调整心脏起搏间隔。 本发明可以被实现为由基于微处理器的可植入医疗装置执行的计算机可读指令。

    Dual chamber pacing system and method with automatic adjustment of the AV escape interval for treating cardiomyopathy
    7.
    发明授权
    Dual chamber pacing system and method with automatic adjustment of the AV escape interval for treating cardiomyopathy 失效
    双室起搏系统及方法，自动调整心肌病AV逃逸间隔

    公开(公告)号：US5527347A

    公开(公告)日：1996-06-18

    申请号：US391884

    申请日：1995-02-21

    申请人： Michael B. Shelton ,  Dwight H. Warkentin

    发明人： Michael B. Shelton ,  Dwight H. Warkentin

    IPC分类号： A61N1/368 ,  A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/3682

    摘要： There is provided a dual chamber pacemaker system and method for ventricular pacing to provide therapy for a patient with cardiomyopathy, this system being characterized by automatically adjusting the AV escape interval so that ventricular pace pulses are delivered at an AV delay which is optimized for HOCM and/or dialated cardiomyopathy therapy. The pacemaker system continually obtains and stores representations of a QRS wave characteristic such as duration, derived either directly from the QRS signal or from an FFRS signal, and compares duration data from one or more cycles to prior stored duration data. The system then adjusts the AV interval as a function of the duration comparison, and the direction of the last adjustment of AV escape interval. By this means, the AV escape interval is maintained at or just short of the onset of fusion, thereby automatically providing for optimally lengthened AV escape intervals consistent with full capture by the delivered ventricular pace pulse.

    摘要翻译： 提供了一种用于心室起搏的双室心脏起搏器系统和方法，用于为患有心肌病的患者提供治疗，该系统的特征在于自动调节AV逃逸间隔，使得心室起搏脉冲在AV延迟下被传递，该AV延迟被优化用于HOCM， /或拨号心肌病治疗。 起搏器系统连续地获得并存储QRS波特征的表示，例如持续时间，直接从QRS信号或从FFRS信号导出，并将来自一个或多个周期的持续时间数据与先前存储的持续时间数据进行比较。 然后，系统根据持续时间比较调整AV间隔，并调整AV转义间隔的最后调整方向。 通过这种方式，AV逃逸间隔保持在融合开始或短于融合开始，从而自动提供与被传递的心室起搏脉冲的完全捕获相一致的最佳延长的AV逃逸间隔。

    Communications system for an implantable device and a drug dispenser
    10.
    发明授权
    Communications system for an implantable device and a drug dispenser 失效
    用于可植入装置和药物分配器的通信系统

    公开(公告)号：US06471645B1

    公开(公告)日：2002-10-29

    申请号：US09475709

    申请日：1999-12-30

    申请人： Dwight H. Warkentin ,  Bozidar Ferek-Petric

    发明人： Dwight H. Warkentin ,  Bozidar Ferek-Petric

    IPC分类号： A61B500

    CPC分类号： A61N1/37282 ,  A61N1/08 ,  Y10S128/903 ,  Y10S128/904 ,  Y10S128/92

    摘要： A closed loop system for monitoring drug dose, intake and effectiveness includes a pill dispenser in data communications with at least one implantable medical device. The system is preferably implemented in a web-enabled environment in which a remote data center communicates with the implantable devices (IMDs) in a patient via a programmer or the pill dispenser. Th data center includes high speed computers and databases relating to patient history and device information. A physician or clinician may access the remote data center to review and monitor the IMDs remotely. More specifically, the IMDs are adapted to chronically monitor the pill dispenser to thereby log and document drug dose, patient compliance with prescriptive regimens and as well to monitor drug efficacy in the patient. The system further provides a dynamic drug management system, compatible with a web-enabled interactive data communication environment, that accurately monitors dose and specific drug effectiveness in a patient to enhance patient care.

    摘要翻译： 用于监测药物剂量，摄入量和有效性的闭环系统包括与至少一个可植入医疗装置的数据通信中的药丸分配器。 该系统优选地在web启用的环境中实现，其中远程数据中心通过编程器或药丸分配器与患者中的可植入装置（IMD）通信。 数据中心包括与病历和设备信息相关的高速计算机和数据库。 医生或临床医生可以访问远程数据中心以远程审查和监视IMD。 更具体地，IMD适于长期监测药丸分配器，从而记录和记录药物剂量，患者对规定方案的依从性以及监测患者的药物功效。 该系统进一步提供了一种动态药物管理系统，与能够准确地监测患者剂量和特异性药物效力的网络互动数据通信环境兼容以增强患者护理。