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    High impedance active fixation electrode of an electrical medical lead
    6.
    发明授权
    High impedance active fixation electrode of an electrical medical lead 有权
    电气医用引线的高阻抗主动固定电极

    公开(公告)号：US08332051B2

    公开(公告)日：2012-12-11

    申请号：US12782465

    申请日：2010-05-18

    申请人： John L. Sommer ,  Daniel C. Sigg ,  James A. Coles, Jr.

    发明人： John L. Sommer ,  Daniel C. Sigg ,  James A. Coles, Jr.

    IPC分类号： A61N1/00

    CPC分类号： A61N1/0573

    摘要： Electrical medical leads having active fixation electrodes, particularly helix electrodes intended to be screwed into body tissue, e.g., the heart, are disclosed having selectively applied insulation to optimize exposed electrode surface area and dispose the exposed electrode surface area toward tissue that is less traumatized by injury caused by screwing in the fixation helix. In a preferred fabrication method, an outer helical surface is masked by contact with a masking tube while a dielectric coating is applied to the inner helical surface of the coil turns of the helix, and the masking tube is removed when the dielectric coating has set. In one variation, at least one aperture is formed through the masking tube sidewall exposing an area of the outer helical surface thereby interrupting the uninsulated outer helical electrode.

    摘要翻译： 公开了具有主动固定电极的电医疗引线，特别是旨在拧入身体组织（例如心脏）的螺旋电极，其具有选择性地施加的绝缘体以优化暴露的电极表面积，并将暴露的电极表面区域设置成较少受到创伤的组织 螺钉固定螺旋引起的损伤。 在优选的制造方法中，外部螺旋表面通过与掩蔽管的接触而被掩蔽，同时将电介质涂层施加到螺旋线圈匝的内螺旋形表面，并且当电介质涂层固化时，掩蔽管被去除。 在一个变型中，通过掩蔽管侧壁形成至少一个孔，暴露外螺旋表面的一个区域，从而中断未绝缘的外螺旋电极。

    HIGH IMPEDANCE ACTIVE FIXATION ELECTRODE OF AN ELECTRICAL MEDICAL LEAD
    7.
    发明申请
    HIGH IMPEDANCE ACTIVE FIXATION ELECTRODE OF AN ELECTRICAL MEDICAL LEAD 有权
    电气医疗铅的高阻抗活性固定电极

    公开(公告)号：US20100292768A1

    公开(公告)日：2010-11-18

    申请号：US12782465

    申请日：2010-05-18

    申请人： John L. Sommer ,  Daniel C. Sigg ,  James A. Coles, JR.

    发明人： John L. Sommer ,  Daniel C. Sigg ,  James A. Coles, JR.

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0573

    摘要： Electrical medical leads having active fixation electrodes, particularly helix electrodes intended to be screwed into body tissue, e.g., the heart, are disclosed having selectively applied insulation to optimize exposed electrode surface area and dispose the exposed electrode surface area toward tissue that is less traumatized by injury caused by screwing in the fixation helix. In a preferred fabrication method, an outer helical surface is masked by contact with a masking tube while a dielectric coating is applied to the inner helical surface of the coil turns of the helix, and the masking tube is removed when the dielectric coating has set. In one variation, at least one aperture is formed through the masking tube sidewall exposing an area of the outer helical surface thereby interrupting the uninsulated outer helical electrode.

    摘要翻译： 公开了具有主动固定电极的电医疗引线，特别是旨在拧入身体组织（例如心脏）的螺旋电极，其具有选择性地施加的绝缘体以优化暴露的电极表面积，并将暴露的电极表面区域设置成较少受到创伤的组织 螺钉固定螺旋引起的损伤。 在优选的制造方法中，外部螺旋表面通过与掩蔽管的接触而被掩蔽，同时将电介质涂层施加到螺旋线圈匝的内螺旋形表面，并且当电介质涂层固化时，掩蔽管被去除。 在一个变型中，通过掩蔽管侧壁形成至少一个孔，暴露外螺旋表面的一个区域，从而中断未绝缘的外螺旋电极。

    Medical fluid delivery system
    8.
    发明授权
    Medical fluid delivery system 有权
    医疗液体输送系统

    公开(公告)号：US07274966B2

    公开(公告)日：2007-09-25

    申请号：US10754173

    申请日：2004-01-08

    申请人： John L. Sommer ,  James A. Coles, Jr. ,  Daniel C. Sigg

    发明人： John L. Sommer ,  James A. Coles, Jr. ,  Daniel C. Sigg

    IPC分类号： A61N1/00

    CPC分类号： A61M25/0082 ,  A61M25/0026 ,  A61M25/0084 ,  A61M2025/0089 ,  A61M2025/0095 ,  A61N1/05 ,  A61N1/0575 ,  A61N1/0587

    摘要： A medical fluid delivery system includes an implantable medical lead including a fixation element adapted to secure the lead to a tissue site and a fluid delivery device including a tissue piercing distal tip; the device is adapted to pass through a proximal port, a lumen and a distal port of the lead. The system further includes means for adjusting a position of the device distal tip with respect to the lead distal port.

    摘要翻译： 医疗流体递送系统包括可植入医疗引线，其包括适于将引线固定到组织部位的固定元件和包括组织穿刺远端的流体输送装置; 该装置适于穿过导线的近端口，内腔和远端口。 所述系统还包括用于调节所述装置远侧尖端相对于所述引线远端端口的位置的装置。

    Rate control during AF using cellular intervention to modulate AV node
    9.
    发明授权
    Rate control during AF using cellular intervention to modulate AV node 有权
    使用细胞干预调整AV节点的AF期间的速率控制

    公开(公告)号：US08565898B2

    公开(公告)日：2013-10-22

    申请号：US11116621

    申请日：2005-04-28

    申请人： Vinod Sharma ,  Daniel C. Sigg

    发明人： Vinod Sharma ,  Daniel C. Sigg

    IPC分类号： A61N1/00 ,  A61K38/00 ,  A61K38/16

    CPC分类号： A61N1/362 ,  A61K9/0019 ,  A61K31/221 ,  A61K38/177 ,  A61N1/0568

    摘要： A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient-specific needs.

    摘要翻译： 生物干预方法和装置对于在该药剂已经成熟但随后随后施用药剂而可变化的生理稳定的AV节点产生持久性修饰。 具体地，通用代理用于调制心脏传导系统中的节点，包括使用一个K +通道或等效物系的组合的速率控制。 具体地，通过在动作电位和复极相优化期间产生向外的电流来实现缓慢传导，从而减少可用于激发下游单元的电流。 例如，可以使用Kv1.3通道作为生物通道。 本发明能够根据医疗和患者特定的需要逆转各种心率（BPM）的调节或调整。

    PRESSURE MONITORING TO CONTROL DELIVERY OF THERAPEUTIC AGENT
    10.
    发明申请
    PRESSURE MONITORING TO CONTROL DELIVERY OF THERAPEUTIC AGENT 有权
    压力监测控制治疗药物的输送

    公开(公告)号：US20100274221A1

    公开(公告)日：2010-10-28

    申请号：US12767224

    申请日：2010-04-26

    申请人： Daniel C. Sigg ,  Prasanga D. Hiniduma-Lokuge ,  Mary M. Morris

    发明人： Daniel C. Sigg ,  Prasanga D. Hiniduma-Lokuge ,  Mary M. Morris

    IPC分类号： A61M5/172 ,  A61B5/03

    CPC分类号： A61B5/036 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/4839 ,  A61M5/14276 ,  A61M5/16854 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3331 ,  A61M2205/3334

    摘要： A method for adjusting delivery of a therapeutic fluid to a patient suffering from or at risk of pulmonary arterial hypertension includes introducing the therapeutic fluid to a patient via a catheter at a predetermined rate. The catheter is positioned to deliver the fluid to the right ventricle or the pulmonary artery. The catheter a one-way valve configured to allow the fluid to flow from the catheter to the target location. The method further includes monitoring pressure of the target location by monitoring internal catheter pressure, and adjusting the rate at which the therapeutic fluid is introduced to the catheter based on the monitored pressure. The rate at which the fluid is introduced to the catheter is increased if internal catheter pressure increases, and the rate at which the fluid is introduced to the catheter is decreased if the internal catheter pressure decreases.

    摘要翻译： 用于调节对患有或具有肺动脉高压的风险的患者的治疗流体的递送的方法包括以预定的速率经由导管将治疗流体引入患者体内。 定位导管以将流体输送到右心室或肺动脉。 导管是单向阀，其构造成允许流体从导管流到目标位置。 该方法还包括通过监测内部导管压力来监测目标位置的压力，并且基于所监测的压力来调节治疗流体被引入导管的速率。 如果内部导管压力增加，流体被引入导管的速率增加，并且如果内部导管压力降低，则将流体引入导管的速率降低。