公开(公告)号：US09683028B2

公开(公告)日：2017-06-20

申请号：US14557171

申请日：2014-12-01

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner ,  Edward Hirsch Cohen ,  Horacio Gabriel Nastri ,  Kristin L. Rookey ,  Rene Hoet ,  Hendricus Renerus Jacobus Mattheus Hoogenboom

IPC: C40B40/08 ,  C07K16/00 ,  C12N15/10 ,  C12N15/66 ,  C40B40/02

CPC classification number: C07K16/005 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/622 ,  C12N15/10 ,  C12N15/1037 ,  C12N15/1093 ,  C12N15/66 ,  C40B40/02 ,  C40B40/08

Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.

公开(公告)号：US20210087256A1

公开(公告)日：2021-03-25

申请号：US16984655

申请日：2020-08-04

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner ,  Edward H. Cohen ,  Horacio G. Nastri ,  Kristin L. Rookey ,  Rene Hoet ,  Hendricus Renerus Jacobus Mattheus Hoogenboom

IPC: C07K16/00 ,  C12N15/10 ,  C12N15/66 ,  C40B40/02

Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.

公开(公告)号：US20150158932A1

公开(公告)日：2015-06-11

申请号：US14557171

申请日：2014-12-01

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner ,  Edward Hirsch Cohen ,  Horacio Gabriel Nastri ,  Kristin L. Rookey ,  Rene Hoet ,  Hendricus Renerus Jacobus Mattheus Hoogenboom

IPC: C07K16/00

CPC classification number: C07K16/005 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/622 ,  C12N15/10 ,  C12N15/1037 ,  C12N15/1093 ,  C12N15/66 ,  C40B40/02 ,  C40B40/08

Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.

Abstract translation: 用于构建共同显示和/或表达肽，多肽或蛋白质不同家族成员的文库的方法和使用这些方法产生的文库。 筛选这些文库和通过这种筛选鉴定的肽，多肽或蛋白质的方法。

公开(公告)号：US10829541B2

公开(公告)日：2020-11-10

申请号：US15612938

申请日：2017-06-02

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner ,  Edward H. Cohen ,  Horacio G. Nastri ,  Kristin L. Rookey ,  Rene Hoet ,  Hendricus Renerus Jacobus Mattheus Hoogenboom

IPC: C40B50/06 ,  C07K16/00 ,  C12N15/10 ,  C12N15/66 ,  C40B40/02 ,  C40B40/08

Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.

公开(公告)号：US20170369557A1

公开(公告)日：2017-12-28

申请号：US15612938

申请日：2017-06-02

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner ,  Edward H. Cohen ,  Horacio G. Nastri ,  Kristin L. Rookey ,  Rene Hoet ,  Hendricus Renerus Jacobus Mattheus Hoogenboom

IPC: C07K16/00 ,  C40B40/02 ,  C12N15/10 ,  C12N15/66 ,  C40B40/08

Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.

公开(公告)号：US20150023978A1

公开(公告)日：2015-01-22

申请号：US14157967

申请日：2014-01-17

Applicant: Baxter International Inc. ,  Dyax Corp. ,  Baxter Healthcare SA

Inventor： Randolf Kerschbaumer ,  Friedrich Scheiflinger ,  Manfred Rieger ,  Michael Thiele ,  Geert C. Mudde ,  Juergen Muellberg ,  Rene Hoet

IPC: C07K16/24

CPC classification number: C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The invention also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.

Abstract translation: 本发明涉及特异性结合巨噬细胞迁移抑制因子（MIF）的C端或中心区域的单克隆抗体及其抗原结合部分。 这些抗MIF抗体及其抗原结合部分进一步抑制人MIF生物学功能。 本发明还涉及衍生自抗MIF抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及鉴定抗MIF抗体的方法，包含这些抗体的药物组合物和使用这些抗体和组合物用于治疗MIF相关病症的方法。