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    READ-AFTER-WRITE DETECTION OF ANALYTES VIA NANOPARTICLE-LABELED SUBSTANCES
    5.
    发明申请
    READ-AFTER-WRITE DETECTION OF ANALYTES VIA NANOPARTICLE-LABELED SUBSTANCES 审中-公开
    通过纳米材料标签物质的分析仪的后读写检测

    公开(公告)号：US20110076782A1

    公开(公告)日：2011-03-31

    申请号：US12888394

    申请日：2010-09-22

    申请人： Tara L. Awezec ,  Dylan Joseph Boday ,  Lee Curtis Randall ,  Stephen Leonard Schwartz ,  Anna W. Topol ,  Daniel James Winarski

    发明人： Tara L. Awezec ,  Dylan Joseph Boday ,  Lee Curtis Randall ,  Stephen Leonard Schwartz ,  Anna W. Topol ,  Daniel James Winarski

    IPC分类号： G01N33/53 ,  B01J19/00

    CPC分类号： G01N33/54346 ,  B82Y15/00 ,  G01N33/54326 ,  G01N33/54333

    摘要： Embodiments of the invention relate to magnetizing and detecting nanoparticle-labeled antigens on biosample tracks deposited on a tape media. An aspect of the invention comprises apparatus and methods for labeling antigens with demagnetized nanoparticles, magnetizing the nanoparticles with an electromagnetic write head, and detecting the antigens via the magnetized nanoparticles by reading the tape media with a read sensor in a read-after-write operation. The write head and read sensor are part of a head-module of magnetic tape drive. Target antigens are attached to the biosample tracks by antibodies. Nanoparticles of differing magnetic properties may be selectively paired with antibodies associated with different antigens to allow multiple antigens to be detected upon a single scan by the read sensor.

    摘要翻译： 本发明的实施方案涉及在沉积在带介质上的生物样品轨道上磁化和检测纳米颗粒标记的抗原。 本发明的一个方面包括用去磁纳米颗粒标记抗原的装置和方法，用电磁写头磁化纳米颗粒，并通过在读写操作中用读取传感器读取磁带介质，通过磁化纳米颗粒检测抗原 。 写头和读取传感器是磁带驱动器的头模块的一部分。 靶抗原通过抗体连接到生物样品轨道上。 具有不同磁性的纳米颗粒可以与与不同抗原相关的抗体选择性配对，以允许通过读取传感器进行单次扫描来检测多个抗原。

    Servo control circuit for detecting analytes via nanoparticle-labeled substances with electromagnetic read-write heads
    7.
    发明授权
    Servo control circuit for detecting analytes via nanoparticle-labeled substances with electromagnetic read-write heads 有权
    用于通过具有电磁读写头的纳米颗粒标记物质检测分析物的伺服控制电路

    公开(公告)号：US08694280B2

    公开(公告)日：2014-04-08

    申请号：US12888403

    申请日：2010-09-22

    申请人： Tara L. Awezec ,  Dylan Joseph Boday ,  Stephen Leonard Schwartz ,  Anna W. Topol ,  Daniel James Winarski

    发明人： Tara L. Awezec ,  Dylan Joseph Boday ,  Stephen Leonard Schwartz ,  Anna W. Topol ,  Daniel James Winarski

    IPC分类号： G01C9/00

    CPC分类号： G01N33/54346 ,  B82Y15/00 ,  G01N33/54326 ,  G01N33/54333

    摘要： A circuit for controlling an electromagnetic head module to detect antigens on a biosample track comprising a processor for receiving position-error-servo signal from the PES read sensor, a write head for magnetizing nanoparticles attached to antigens, and a read sensor for detecting the nanoparticle-labeled antigens. The circuit may further comprise an X-axis actuator for controlling the head module in the direction perpendicular to the track and an Y-axis actuator coupled to the head module and the X-axis actuator for controlling the head module in the direction of the track. Target antigens are attached to the biosample track and nanoparticles via antibodies.

    摘要翻译： 一种用于控制电磁头模块以检测生物样本轨道上的抗原的电路，包括用于从PES读取传感器接收位置误差伺服信号的处理器，用于磁化附着于抗原的纳米颗粒的写入头和用于检测纳米颗粒的读取传感器 标记的抗原。 电路还可以包括用于在垂直于轨道的方向上控制头模块的X轴致动器，以及耦合到头模块的Y轴致动器和用于在轨道方向上控制头模块的X轴致动器 。 靶抗原通过抗体连接到生物样品轨道和纳米颗粒上。

    Method for calibrating read sensors of electromagnetic read-write heads
    8.
    发明授权
    Method for calibrating read sensors of electromagnetic read-write heads 有权
    校准电磁读写头读取传感器的方法

    公开(公告)号：US08855957B2

    公开(公告)日：2014-10-07

    申请号：US13099360

    申请日：2011-05-03

    申请人： David Berman ,  Dylan Joseph Boday ,  Icko E. T. Iben ,  Wayne Isami Imaino ,  Stephen Leonard Schwartz ,  Anna Wanda Topol ,  Daniel James Winarski

    发明人： David Berman ,  Dylan Joseph Boday ,  Icko E. T. Iben ,  Wayne Isami Imaino ,  Stephen Leonard Schwartz ,  Anna Wanda Topol ,  Daniel James Winarski

    IPC分类号： G01D18/00 ,  G01C25/00 ,  G01R33/00 ,  G01R33/12

    CPC分类号： G01R35/00 ,  G01N27/04 ,  G01N27/72 ,  G01N33/53 ,  G01R33/0035 ,  G01R33/1207

    摘要： Described are embodiments to ensure that the equipment utilized to detect antigens is reliable and accurate. If it is determined that a read sensor is degraded a method of calibrating a read sensor of a read head is described. In one embodiment, a method of calibrating a magnetic read sensor includes measuring a first resistance of the magnetic read sensor upon an application of a forward bias current to the magnetic read sensor and measuring a second resistance of the magnetic read sensor upon an application of a reverse bias current to the magnetic read sensor. A calibration constant is determined based on at least the first measured resistance and the second measured resistance. In one embodiment the method further includes storing the determined calibration constant for the magnetic read sensor in memory. Further, in one embodiment the head module having the magnetic read sensor is swept over at least one nanoparticle to obtain a read response of the magnetic read sensor to the nanoparticle. The read response from the magnetic read sensor of the at least one nanoparticle is adjusted based on the determined calibration constant. Calibration of each individual read sensor allows for uniform read responses from each of the read sensors on a read head, and prevents unreliable an inaccurate detection of analytes due to sensor degradation.

    摘要翻译： 描述了确保用于检测抗原的设备是可靠和准确的实施方案。 如果确定读取传感器劣化，则描述校准读取头的读取传感器的方法。 在一个实施例中，一种校准磁性读取传感器的方法包括：在向磁性读取传感器施加正向偏置电流时测量磁性读取传感器的第一个电阻，并测量磁性读取传感器的应用时的第二个电阻 反向偏置电流到磁性读取传感器。 基于至少第一测量电阻和第二测量电阻来确定校准常数。 在一个实施例中，该方法还包括将所确定的磁读取传感器的校准常数存储在存储器中。 此外，在一个实施例中，具有磁读取传感器的头模块扫过至少一个纳米颗粒，以获得磁读取传感器对纳米颗粒的读取响应。 基于所确定的校准常数来调整来自至少一个纳米颗粒的磁读取传感器的读取响应。 每个单独的读取传感器的校准允许来自读取头上的每个读取传感器的均匀的读取响应，并且防止由于传感器劣化而导致的分析物不可靠的检测不可靠。

    Calibration assembly for aide in detection of analytes with electromagnetic read-write heads
    9.
    发明授权
    Calibration assembly for aide in detection of analytes with electromagnetic read-write heads 有权
    用于检测电磁读写头的分析物的校准组件

    公开(公告)号：US09040311B2

    公开(公告)日：2015-05-26

    申请号：US13099358

    申请日：2011-05-03

    申请人： David Berman ,  Dylan Joseph Boday ,  Icko E.T. Iben ,  Wayne Isami Imaino ,  Stephen Leonard Schwartz ,  Anna Wanda Topol ,  Daniel James Winarski

    发明人： David Berman ,  Dylan Joseph Boday ,  Icko E.T. Iben ,  Wayne Isami Imaino ,  Stephen Leonard Schwartz ,  Anna Wanda Topol ,  Daniel James Winarski

    IPC分类号： H01L21/00 ,  G01R33/00 ,  G01R33/12 ,  G01N27/74

    CPC分类号： G01R33/0035 ,  G01N27/72 ,  G01N27/745 ,  G01R33/09 ,  G01R33/1269 ,  G01R35/00 ,  G01R35/005

    摘要： Described are embodiments to ensure that the equipment utilized to detect antigens is reliable and accurate. Accordingly, one embodiment of the invention includes a calibration assembly having nanoparticles, with known magnetic properties, spaced apart at known y-axis locations along the calibration assembly. In one embodiment, the calibration assembly may be used to calibrate a matched filter of the write and read circuitry. Because the calibration assembly comprises nanoparticles with known magnetic properties the read response of the read circuitry to a particular nanoparticle may be stored in the matched filter as an ideal signal for that nanoparticle. The ideal signal stored in the matched filter may then be utilized for reliably and accurately detecting antigens. Still further, the ideal signal stored within the matched filter of the write and read circuitry may be utilized in a correlation test of a calibration assembly to ensure that the calibration assembly is within a manufacturer's or user's acceptable standards for calibration of their write and read assemblies.

    摘要翻译： 描述了确保用于检测抗原的设备是可靠和准确的实施方案。 因此，本发明的一个实施例包括具有已知磁性的纳米颗粒的校准组件，沿着校准组件在已知的y轴位置间隔开。 在一个实施例中，校准组件可用于校准写入和读取电路的匹配滤波器。 因为校准组件包括具有已知磁性的纳米颗粒，读取电路对特定纳米颗粒的读取响应可以作为该纳米颗粒的理想信号存储在匹配滤波器中。 然后可以将存储在匹配滤波器中的理想信号用于可靠且准确地检测抗原。 此外，存储在写入和读取电路的匹配滤波器内的理想信号可以用于校准组件的相关测试中，以确保校准组件在制造商或用户可接受的标准内用于校准其写入和读取组件 。

    Calibration Assembly for Aide in Detection of Analytes with Electromagnetic Read-Write Heads
    10.
    发明申请
    Calibration Assembly for Aide in Detection of Analytes with Electromagnetic Read-Write Heads 有权
    用电磁读写头检测分析物的助听器校准组件

    公开(公告)号：US20120280675A1

    公开(公告)日：2012-11-08

    申请号：US13099358

    申请日：2011-05-03

    申请人： David Berman ,  Dylan Joseph Boday ,  Icko E.T. Iben ,  Wayne Isami Imaino ,  Stephen Leonard Schwartz ,  Anna Wanda Topol ,  Daniel James Winarski

    发明人： David Berman ,  Dylan Joseph Boday ,  Icko E.T. Iben ,  Wayne Isami Imaino ,  Stephen Leonard Schwartz ,  Anna Wanda Topol ,  Daniel James Winarski

    IPC分类号： G01R35/00 ,  B29C71/04 ,  B05D5/12

    CPC分类号： G01R33/0035 ,  G01N27/72 ,  G01N27/745 ,  G01R33/09 ,  G01R33/1269 ,  G01R35/00 ,  G01R35/005

    摘要： Described are embodiments to ensure that the equipment utilized to detect antigens is reliable and accurate. Accordingly, one embodiment of the invention includes a calibration assembly having nanoparticles, with known magnetic properties, spaced apart at known y-axis locations along the calibration assembly. In one embodiment, the calibration assembly may be used to calibrate a matched filter of the write and read circuitry. Because the calibration assembly comprises nanoparticles with known magnetic properties the read response of the read circuitry to a particular nanoparticle may be stored in the matched filter as an ideal signal for that nanoparticle. The ideal signal stored in the matched filter may then be utilized for reliably and accurately detecting antigens. Still further, the ideal signal stored within the matched filter of the write and read circuitry may be utilized in a correlation test of a calibration assembly to ensure that the calibration assembly is within a manufacturer's or user's acceptable standards for calibration of their write and read assemblies.

    摘要翻译： 描述了确保用于检测抗原的设备是可靠和准确的实施方案。 因此，本发明的一个实施例包括具有已知磁性的纳米颗粒的校准组件，沿着校准组件在已知的y轴位置间隔开。 在一个实施例中，校准组件可用于校准写入和读取电路的匹配滤波器。 因为校准组件包括具有已知磁性的纳米颗粒，读取电路对特定纳米颗粒的读取响应可以存储在匹配滤波器中作为该纳米颗粒的理想信号。 然后可以将存储在匹配滤波器中的理想信号用于可靠且准确地检测抗原。 此外，存储在写入和读取电路的匹配滤波器内的理想信号可以用于校准组件的相关测试，以确保校准组件在制造商或用户可接受的标准内用于校准其写入和读取组件 。