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    Trenched sample assembly for detection of analytes with electromagnetic read-write heads
    4.
    发明授权
    Trenched sample assembly for detection of analytes with electromagnetic read-write heads 有权
    用电磁读写头检测分析物的倾斜样品组件

    公开(公告)号：US09304130B2

    公开(公告)日：2016-04-05

    申请号：US12970837

    申请日：2010-12-16

    申请人： Dylan J. Boday ,  Stephen L. Schwartz ,  Anna Wanda Topol ,  Sandra L. Waters ,  Daniel J. Winarski

    发明人： Dylan J. Boday ,  Stephen L. Schwartz ,  Anna Wanda Topol ,  Sandra L. Waters ,  Daniel J. Winarski

    IPC分类号： G01N33/553 ,  G01N33/543 ,  B82Y15/00

    CPC分类号： G01N33/54333 ,  B82Y15/00 ,  G01N27/745 ,  G01N33/543 ,  G01N33/54346 ,  G01N33/54366

    摘要： Described are embodiments of an invention for a sample assembly with trenches for detection of analytes with electromagnetic read heads. The sample assembly includes an outer layer with at least one sample trench. The sample trench includes a first set of antibodies that are bonded on a first surface of a base layer. Target antigens are bonded with the first set of antibodies, and a second set of antibodies are bonded to the target antigens. Further, the sample trench includes nanoparticles that are bonded to the second set of antibodies. A head module includes a write head for magnetizing nanoparticles and a read sensor for detecting the magnetized nanoparticles, and thus, the target antigens. The sample trench constrains the biological sample, and thus the target antigen, during the preparation and subsequent analysis of the biological sample. Accordingly, the target antigen is aligned with read elements of a head module such that the target antigen is reliably and accurately detected. Further, to ensure reliable and accurate detection, the outer layer is formed with a low friction material allowing the read head to remain in contact with the upper surface of the outer layer during the process of detection.

    摘要翻译： 描述了具有用于检测具有电磁读取头的分析物的沟槽的样品组件的发明的实施例。 样品组件包括具有至少一个样品沟槽的外层。 样品槽包括结合在基层的第一表面上的第一组抗体。 靶抗原与第一组抗体结合，第二组抗体与靶抗原结合。 此外，样品沟槽包括与第二组抗体结合的纳米颗粒。 头模块包括用于磁化纳米颗粒的写入头和用于检测磁化纳米颗粒的读取传感器，从而检测靶抗原。 样品沟槽在生物样品的制备和随后分析过程中约束生物样品，从而限制靶抗原。 因此，目标抗原与头部模块的读取元件对准，从而可靠且准确地检测靶抗原。 此外，为了确保可靠且准确的检测，外层由低摩擦材料形成，允许读取头在检测过程中与外层的上表面保持接触。

    Method for calibrating read sensors of electromagnetic read-write heads
    5.
    发明授权
    Method for calibrating read sensors of electromagnetic read-write heads 有权
    校准电磁读写头读取传感器的方法

    公开(公告)号：US08855957B2

    公开(公告)日：2014-10-07

    申请号：US13099360

    申请日：2011-05-03

    申请人： David Berman ,  Dylan Joseph Boday ,  Icko E. T. Iben ,  Wayne Isami Imaino ,  Stephen Leonard Schwartz ,  Anna Wanda Topol ,  Daniel James Winarski

    发明人： David Berman ,  Dylan Joseph Boday ,  Icko E. T. Iben ,  Wayne Isami Imaino ,  Stephen Leonard Schwartz ,  Anna Wanda Topol ,  Daniel James Winarski

    IPC分类号： G01D18/00 ,  G01C25/00 ,  G01R33/00 ,  G01R33/12

    CPC分类号： G01R35/00 ,  G01N27/04 ,  G01N27/72 ,  G01N33/53 ,  G01R33/0035 ,  G01R33/1207

    摘要： Described are embodiments to ensure that the equipment utilized to detect antigens is reliable and accurate. If it is determined that a read sensor is degraded a method of calibrating a read sensor of a read head is described. In one embodiment, a method of calibrating a magnetic read sensor includes measuring a first resistance of the magnetic read sensor upon an application of a forward bias current to the magnetic read sensor and measuring a second resistance of the magnetic read sensor upon an application of a reverse bias current to the magnetic read sensor. A calibration constant is determined based on at least the first measured resistance and the second measured resistance. In one embodiment the method further includes storing the determined calibration constant for the magnetic read sensor in memory. Further, in one embodiment the head module having the magnetic read sensor is swept over at least one nanoparticle to obtain a read response of the magnetic read sensor to the nanoparticle. The read response from the magnetic read sensor of the at least one nanoparticle is adjusted based on the determined calibration constant. Calibration of each individual read sensor allows for uniform read responses from each of the read sensors on a read head, and prevents unreliable an inaccurate detection of analytes due to sensor degradation.

    摘要翻译： 描述了确保用于检测抗原的设备是可靠和准确的实施方案。 如果确定读取传感器劣化，则描述校准读取头的读取传感器的方法。 在一个实施例中，一种校准磁性读取传感器的方法包括：在向磁性读取传感器施加正向偏置电流时测量磁性读取传感器的第一个电阻，并测量磁性读取传感器的应用时的第二个电阻 反向偏置电流到磁性读取传感器。 基于至少第一测量电阻和第二测量电阻来确定校准常数。 在一个实施例中，该方法还包括将所确定的磁读取传感器的校准常数存储在存储器中。 此外，在一个实施例中，具有磁读取传感器的头模块扫过至少一个纳米颗粒，以获得磁读取传感器对纳米颗粒的读取响应。 基于所确定的校准常数来调整来自至少一个纳米颗粒的磁读取传感器的读取响应。 每个单独的读取传感器的校准允许来自读取头上的每个读取传感器的均匀的读取响应，并且防止由于传感器劣化而导致的分析物不可靠的检测不可靠。

    Calibration assembly for aide in detection of analytes with electromagnetic read-write heads
    6.
    发明授权
    Calibration assembly for aide in detection of analytes with electromagnetic read-write heads 有权
    用于检测电磁读写头的分析物的校准组件

    公开(公告)号：US09040311B2

    公开(公告)日：2015-05-26

    申请号：US13099358

    申请日：2011-05-03

    申请人： David Berman ,  Dylan Joseph Boday ,  Icko E.T. Iben ,  Wayne Isami Imaino ,  Stephen Leonard Schwartz ,  Anna Wanda Topol ,  Daniel James Winarski

    发明人： David Berman ,  Dylan Joseph Boday ,  Icko E.T. Iben ,  Wayne Isami Imaino ,  Stephen Leonard Schwartz ,  Anna Wanda Topol ,  Daniel James Winarski

    IPC分类号： H01L21/00 ,  G01R33/00 ,  G01R33/12 ,  G01N27/74

    CPC分类号： G01R33/0035 ,  G01N27/72 ,  G01N27/745 ,  G01R33/09 ,  G01R33/1269 ,  G01R35/00 ,  G01R35/005

    摘要： Described are embodiments to ensure that the equipment utilized to detect antigens is reliable and accurate. Accordingly, one embodiment of the invention includes a calibration assembly having nanoparticles, with known magnetic properties, spaced apart at known y-axis locations along the calibration assembly. In one embodiment, the calibration assembly may be used to calibrate a matched filter of the write and read circuitry. Because the calibration assembly comprises nanoparticles with known magnetic properties the read response of the read circuitry to a particular nanoparticle may be stored in the matched filter as an ideal signal for that nanoparticle. The ideal signal stored in the matched filter may then be utilized for reliably and accurately detecting antigens. Still further, the ideal signal stored within the matched filter of the write and read circuitry may be utilized in a correlation test of a calibration assembly to ensure that the calibration assembly is within a manufacturer's or user's acceptable standards for calibration of their write and read assemblies.

    摘要翻译： 描述了确保用于检测抗原的设备是可靠和准确的实施方案。 因此，本发明的一个实施例包括具有已知磁性的纳米颗粒的校准组件，沿着校准组件在已知的y轴位置间隔开。 在一个实施例中，校准组件可用于校准写入和读取电路的匹配滤波器。 因为校准组件包括具有已知磁性的纳米颗粒，读取电路对特定纳米颗粒的读取响应可以作为该纳米颗粒的理想信号存储在匹配滤波器中。 然后可以将存储在匹配滤波器中的理想信号用于可靠且准确地检测抗原。 此外，存储在写入和读取电路的匹配滤波器内的理想信号可以用于校准组件的相关测试中，以确保校准组件在制造商或用户可接受的标准内用于校准其写入和读取组件 。

    Calibration Assembly for Aide in Detection of Analytes with Electromagnetic Read-Write Heads
    9.
    发明申请
    Calibration Assembly for Aide in Detection of Analytes with Electromagnetic Read-Write Heads 有权
    用电磁读写头检测分析物的助听器校准组件

    公开(公告)号：US20120280675A1

    公开(公告)日：2012-11-08

    申请号：US13099358

    申请日：2011-05-03

    申请人： David Berman ,  Dylan Joseph Boday ,  Icko E.T. Iben ,  Wayne Isami Imaino ,  Stephen Leonard Schwartz ,  Anna Wanda Topol ,  Daniel James Winarski

    发明人： David Berman ,  Dylan Joseph Boday ,  Icko E.T. Iben ,  Wayne Isami Imaino ,  Stephen Leonard Schwartz ,  Anna Wanda Topol ,  Daniel James Winarski

    IPC分类号： G01R35/00 ,  B29C71/04 ,  B05D5/12

    CPC分类号： G01R33/0035 ,  G01N27/72 ,  G01N27/745 ,  G01R33/09 ,  G01R33/1269 ,  G01R35/00 ,  G01R35/005

    摘要： Described are embodiments to ensure that the equipment utilized to detect antigens is reliable and accurate. Accordingly, one embodiment of the invention includes a calibration assembly having nanoparticles, with known magnetic properties, spaced apart at known y-axis locations along the calibration assembly. In one embodiment, the calibration assembly may be used to calibrate a matched filter of the write and read circuitry. Because the calibration assembly comprises nanoparticles with known magnetic properties the read response of the read circuitry to a particular nanoparticle may be stored in the matched filter as an ideal signal for that nanoparticle. The ideal signal stored in the matched filter may then be utilized for reliably and accurately detecting antigens. Still further, the ideal signal stored within the matched filter of the write and read circuitry may be utilized in a correlation test of a calibration assembly to ensure that the calibration assembly is within a manufacturer's or user's acceptable standards for calibration of their write and read assemblies.

    摘要翻译： 描述了确保用于检测抗原的设备是可靠和准确的实施方案。 因此，本发明的一个实施例包括具有已知磁性的纳米颗粒的校准组件，沿着校准组件在已知的y轴位置间隔开。 在一个实施例中，校准组件可用于校准写入和读取电路的匹配滤波器。 因为校准组件包括具有已知磁性的纳米颗粒，读取电路对特定纳米颗粒的读取响应可以存储在匹配滤波器中作为该纳米颗粒的理想信号。 然后可以将存储在匹配滤波器中的理想信号用于可靠且准确地检测抗原。 此外，存储在写入和读取电路的匹配滤波器内的理想信号可以用于校准组件的相关测试，以确保校准组件在制造商或用户可接受的标准内用于校准其写入和读取组件 。

    Trenched Sample Assembly for Detection of Analytes with Electromagnetic Read-Write Heads
    10.
    发明申请
    Trenched Sample Assembly for Detection of Analytes with Electromagnetic Read-Write Heads 有权
    用于用电磁读写头检测分析物的倾斜的样品组件

    公开(公告)号：US20120157330A1

    公开(公告)日：2012-06-21

    申请号：US12970837

    申请日：2010-12-16

    申请人： Dylan J. Boday ,  Stephen L. Schwartz ,  Anna Wanda Topol ,  Sandra L. Waters ,  Daniel J. Winarski

    发明人： Dylan J. Boday ,  Stephen L. Schwartz ,  Anna Wanda Topol ,  Sandra L. Waters ,  Daniel J. Winarski

    IPC分类号： C40B30/04 ,  C40B50/06 ,  B82Y15/00

    CPC分类号： G01N33/54333 ,  B82Y15/00 ,  G01N27/745 ,  G01N33/543 ,  G01N33/54346 ,  G01N33/54366

    摘要： Described are embodiments of an invention for a sample assembly with trenches for detection of analytes with electromagnetic read heads. The sample assembly includes an outer layer with at least one sample trench. The sample trench includes a first set of antibodies that are bonded on a first surface of a base layer. Target antigens are bonded with the first set of antibodies, and a second set of antibodies are bonded to the target antigens. Further, the sample trench includes nanoparticles that are bonded to the second set of antibodies. A head module includes a write head for magnetizing nanoparticles and a read sensor for detecting the magnetized nanoparticles, and thus, the target antigens. The sample trench constrains the biological sample, and thus the target antigen, during the preparation and subsequent analysis of the biological sample. Accordingly, the target antigen is aligned with read elements of a head module such that the target antigen is reliably and accurately detected. Further, to ensure reliable and accurate detection, the outer layer is formed with a low friction material allowing the read head to remain in contact with the upper surface of the outer layer during the process of detection.

    摘要翻译： 描述了具有用于检测具有电磁读取头的分析物的沟槽的样品组件的发明的实施例。 样品组件包括具有至少一个样品沟槽的外层。 样品槽包括结合在基层的第一表面上的第一组抗体。 靶抗原与第一组抗体结合，第二组抗体与靶抗原结合。 此外，样品沟槽包括与第二组抗体结合的纳米颗粒。 头模块包括用于磁化纳米颗粒的写入头和用于检测磁化纳米颗粒的读取传感器，从而检测靶抗原。 样品沟槽在生物样品的制备和随后分析过程中约束生物样品，从而限制靶抗原。 因此，目标抗原与头部模块的读取元件对准，从而可靠且准确地检测靶抗原。 此外，为了确保可靠且准确的检测，外层由低摩擦材料形成，允许读取头在检测过程中与外层的上表面保持接触。