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公开(公告)号：US11813422B2
公开(公告)日：2023-11-14
申请号：US17723686
申请日：2022-04-19
发明人： Pu Zhou , Bin Tian , Yidong M. Zhu
IPC分类号： A61M25/10 , B23K26/402 , B23K26/0622 , B21D39/00 , B23K26/362 , B23K26/361 , B23K26/06 , B23K103/00
CPC分类号： A61M25/1029 , B21D39/00 , B23K26/0624 , B23K26/0626 , B23K26/361 , B23K26/362 , B23K26/402 , A61M2025/107 , A61M2025/1031 , A61M2025/1075 , A61M2025/1079 , A61M2025/1084 , A61M2025/1086 , A61M2025/1088 , B23K2103/42 , B23K2103/50
摘要： Inflatable devices are disclosed including a surface which has a network of polymer chains and is configured to be inflatable into a therapeutically or diagnostically useful shape, and at least one ultrashort laser pulse-formed modification in the surface. The network can, for example, include a network morphology that is substantially unchanged by modification with the ultrashort pulse laser. Ultrashort laser pulses can be laser pulses equal to or less than 1000 picoseconds in duration. Advantageously, the etching process uses a relatively low-heat laser to avoid significant heating of surrounding polymers while modifying the surface (and other structures) of the device. The process is configured so that the polymer chain morphology adjacent the modification is substantially unaffected by the low-heat laser. The resulting inflatable device has customized surface features while still retaining substantially homogenous polymer network morphology. This preserves the elasticity, especially the surface elasticity, of the inflatable device.
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公开(公告)号：US11213385B2
公开(公告)日：2022-01-04
申请号：US16154353
申请日：2018-10-08
发明人： Jeffrey S. Dove , Bin Tian , Ralph Schneider , Jeffrey S. Cohen , Ivan Jankovic , John F. Migliazza , Gregory A. Wright , James M. Young , Louis A. Campbell
摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes.
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公开(公告)号：US20160144156A1
公开(公告)日：2016-05-26
申请号：US14938761
申请日：2015-11-11
发明人： Pu Zhou , Bin Tian , Yidong M. Zhu
IPC分类号： A61M25/10 , B23K26/402 , B23K26/362
CPC分类号： A61M25/1029 , A61M2025/1031 , A61M2025/1086 , B23K26/0624 , B23K26/361 , B23K26/362 , B23K26/402 , B23K2103/42 , B23K2103/50
摘要： Inflatable devices are disclosed including a surface which has a network of polymer chains and is configured to be inflatable into a therapeutically or diagnostically useful shape, and at least one ultrashort laser pulse-formed modification in the surface. The network can, for example, include a network morphology that is substantially unchanged by modification with the ultrashort pulse laser. Ultrashort laser pulses can be laser pulses equal to or less than 1000 picoseconds in duration. Advantageously, the etching process uses a relatively low-heat laser to avoid significant heating of surrounding polymers while modifying the surface (and other structures) of the device. The process is configured so that the polymer chain morphology adjacent the modification is substantially unaffected by the low-heat laser. The resulting inflatable device has customized surface features while still retaining substantially homogenous polymer network morphology. This preserves the elasticity, especially the surface elasticity, of the inflatable device.
摘要翻译： 公开了充气装置，其包括具有聚合物链网络并被配置为可膨胀成治疗或诊断上有用的形状的表面，以及表面中的至少一个超短激光脉冲形成的修饰。 例如，网络可以包括通过使用超短脉冲激光器进行修改而基本上不变的网络形态。 超短激光脉冲可以是等于或小于1000皮秒的激光脉冲。 有利地，蚀刻工艺使用相对低热的激光器来避免周围聚合物的显着加热，同时改变装置的表面（和其它结构）。 该方法被配置成使得邻近修饰的聚合物链形态基本上不受低热激光的影响。 所得到的充气装置具有定制的表面特征，同时仍然保持基本均匀的聚合物网络形态。 这保持了充气装置的弹性，特别是表面弹性。
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公开(公告)号：US20130310929A1
公开(公告)日：2013-11-21
申请号：US13950154
申请日：2013-07-24
发明人： Jeffrey S. Dove , Bin Tian , Ralph Schneider , Jeffrey S. Cohen , Ivan Jankovic , John F. Migliazza , Gregory A. Wright , James Young , Louis A. Campbell
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes.
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公开(公告)号：US12076513B2
公开(公告)日：2024-09-03
申请号：US18379539
申请日：2023-10-12
发明人： Pu Zhou , Bin Tian , Yidong M. Zhu
IPC分类号： A61M25/10 , B21D39/00 , B23K26/06 , B23K26/0622 , B23K26/361 , B23K26/362 , B23K26/402 , B23K103/00
CPC分类号： A61M25/1029 , B21D39/00 , B23K26/0624 , B23K26/0626 , B23K26/361 , B23K26/362 , B23K26/402 , A61M2025/1031 , A61M2025/107 , A61M2025/1075 , A61M2025/1079 , A61M2025/1084 , A61M2025/1086 , A61M2025/1088 , B23K2103/42 , B23K2103/50
摘要： Inflatable devices are disclosed including a surface which has a network of polymer chains and is configured to be inflatable into a therapeutically or diagnostically useful shape, and at least one ultrashort laser pulse-formed modification in the surface. The network can, for example, include a network morphology that is substantially unchanged by modification with the ultrashort pulse laser. Ultrashort laser pulses can be laser pulses equal to or less than 1000 picoseconds in duration. Advantageously, the etching process uses a relatively low-heat laser to avoid significant heating of surrounding polymers while modifying the surface (and other structures) of the device. The process is configured so that the polymer chain morphology adjacent the modification is substantially unaffected by the low-heat laser. The resulting inflatable device has customized surface features while still retaining substantially homogenous polymer network morphology. This preserves the elasticity, especially the surface elasticity, of the inflatable device.
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公开(公告)号：US20220241563A1
公开(公告)日：2022-08-04
申请号：US17723686
申请日：2022-04-19
发明人： Pu Zhou , Bin Tian , Yidong M. Zhu
IPC分类号： A61M25/10 , B23K26/362 , B23K26/402 , B23K26/0622 , B23K26/361 , B21D39/00 , B23K26/06
摘要： Inflatable devices are disclosed including a surface which has a network of polymer chains and is configured to be inflatable into a therapeutically or diagnostically useful shape, and at least one ultrashort laser pulse-formed modification in the surface. The network can, for example, include a network morphology that is substantially unchanged by modification with the ultrashort pulse laser. Ultrashort laser pulses can be laser pulses equal to or less than 1000 picoseconds in duration. Advantageously, the etching process uses a relatively low-heat laser to avoid significant heating of surrounding polymers while modifying the surface (and other structures) of the device. The process is configured so that the polymer chain morphology adjacent the modification is substantially unaffected by the low-heat laser. The resulting inflatable device has customized surface features while still retaining substantially homogenous polymer network morphology. This preserves the elasticity, especially the surface elasticity, of the inflatable device.
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公开(公告)号：US11382738B2
公开(公告)日：2022-07-12
申请号：US16570797
申请日：2019-09-13
IPC分类号： A61F2/24
摘要： Systems, devices, kits, and methods are described for securing a bioprosthetic heart valve within an anatomical feature of a patient. Kits can comprise a bioprosthetic heart valve, a curable composition, and an applicator configured to deliver the curable composition to a target area. The bioprosthetic heart valve can comprise a support structure and one or more valve leaflets coupled thereto. The support structure can comprise a sewing portion peripheral of the bioprosthetic heart valve. The support structure and the valve leaflets can define a central flow orifice. The curable composition can comprise a pre-polymer composition and an initiator. Methods can comprise positioning the bioprosthetic heart valve within the anatomical feature of a patient, applying the curable composition to one or both of the bioprosthetic heart valve and the anatomical feature, and curing the curable composition for a cure time. The applying can be performed before or after the positioning.
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公开(公告)号：US11305098B2
公开(公告)日：2022-04-19
申请号：US16940833
申请日：2020-07-28
发明人： Pu Zhou , Bin Tian , Yidong M. Zhu
IPC分类号： B23K26/0622 , A61M25/10 , B23K26/362 , B23K26/402 , B23K26/361 , B21D39/00 , B23K26/06 , B23K103/00
摘要： Inflatable devices are disclosed including a surface which has a network of polymer chains and is configured to be inflatable into a therapeutically or diagnostically useful shape, and at least one ultrashort laser pulse-formed modification in the surface. The network can, for example, include a network morphology that is substantially unchanged by modification with the ultrashort pulse laser. Ultrashort laser pulses can be laser pulses equal to or less than 1000 picoseconds in duration. Advantageously, the etching process uses a relatively low-heat laser to avoid significant heating of surrounding polymers while modifying the surface (and other structures) of the device. The process is configured so that the polymer chain morphology adjacent the modification is substantially unaffected by the low-heat laser. The resulting inflatable device has customized surface features while still retaining substantially homogenous polymer network morphology. This preserves the elasticity, especially the surface elasticity, of the inflatable device.
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公开(公告)号：US11285004B2
公开(公告)日：2022-03-29
申请号：US16430334
申请日：2019-06-03
发明人： Sven Benjamin Iversen , Adam J. Yestrepsky , Amy E. Munnelly , Bin Tian , Danny Barrientos Baldo, Jr. , Brian S. Conklin , Louis A. Campbell , John Richard Carpenter , Derrick Johnson
摘要： A method for repairing a native valve of a patient during a non-open-heart procedure includes attaching two or more attachment members to the native valve. The method also includes applying a force to the two or more attachment members such that the two or more attachment members cause a cinching effect on at least a portion of the native valve. The method further includes securing the two or more attachment members with one or more anchor members such that the two or more attachment members maintain the cinching effect.
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公开(公告)号：US10722693B2
公开(公告)日：2020-07-28
申请号：US15815599
申请日：2017-11-16
发明人： Pu Zhou , Bin Tian , Yidong M. Zhu
IPC分类号： A61M25/10 , B23K26/362 , B23K26/361 , B21D39/00 , B23K26/06 , B23K26/402 , B23K26/0622 , B23K103/00
摘要： Inflatable devices are disclosed including a surface which has a network of polymer chains and is configured to be inflatable into a therapeutically or diagnostically useful shape, and at least one ultrashort laser pulse-formed modification in the surface. The network can, for example, include a network morphology that is substantially unchanged by modification with the ultrashort pulse laser. Ultrashort laser pulses can be laser pulses equal to or less than 1000 picoseconds in duration. Advantageously, the etching process uses a relatively low-heat laser to avoid significant heating of surrounding polymers while modifying the surface (and other structures) of the device. The process is configured so that the polymer chain morphology adjacent the modification is substantially unaffected by the low-heat laser. The resulting inflatable device has customized surface features while still retaining substantially homogenous polymer network morphology. This preserves the elasticity, especially the surface elasticity, of the inflatable device.
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