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公开(公告)号：US09046292B2
公开(公告)日：2015-06-02
申请号：US13654595
申请日：2012-10-18
Applicant: EMD Millipore Corporation
Inventor： Aaron Burke , Michael Felo , Brian Pereira , Elias Noukas , Dennis Wong
CPC classification number: F25D29/00 , A01N1/0263 , F25D2331/802 , F25D2400/28 , F25D2400/30 , F25D2600/06 , F25D2700/12 , Y10T29/53
Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.
Abstract translation: 本发明的生物容器提供了在生物药物材料的运输，冷冻和解冻期间遇到的许多问题的低成本，简单的解决方案。 本发明使得用户能够在低温过程期间监测每个生物药物容器的温度曲线，以便通过使用预先安装和预灭菌的温度传感器来确保每个生物容器内的材料的完整性。 在一些实施例中，传感器组件包括无线发射器，并且能够发送关于测量读数的信息。 在其他实施例中，传感器组件包括处理单元，其确定温度分布是否可接受。 在另一实施例中，包括指示器，使得处理单元可以指示生物药物材料是否已被适当地冷冻。 在其他实施例中，传感器组件还包括存储元件，其能够在冷冻过程期间存储各种参数。
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Patent Agency Ranking
公开(公告)号：US09027356B2
公开(公告)日：2015-05-12
申请号：US13654593
申请日：2012-10-18
Applicant: EMD Millipore Corporation
Inventor： Aaron Burke , Michael Felo , Brian Pereira , Elias Noukas , Dennis Wong
CPC classification number: F25D29/00 , A01N1/0263 , F25D2331/802 , F25D2400/28 , F25D2400/30 , F25D2600/06 , F25D2700/12 , Y10T29/53
Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.
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公开(公告)号：US20130233777A1
公开(公告)日：2013-09-12
申请号：US13868372
申请日：2013-04-23
Applicant: EMD MILLIPORE CORPORATION
Inventor： Martin Morrissey , Dennis Wong
IPC: B01D35/14
CPC classification number: B01D35/14 , B01D61/20 , B01D63/084 , B01D2313/04 , B01D2313/23 , B01D2313/44 , B01D2313/54 , C02F2209/03 , G01L7/082 , G01N1/10 , G01N1/4005 , Y10T436/25 , Y10T436/25375
Abstract: Tangential flow filtration device is provided wherein liners are provided between the filtration element and the top and bottom holders or manifolds. The liners incorporate the flow channels and inlet and outlet ports, as well as a sensor mount. The liners are made of an inexpensive material and therefore are disposable after a single use, making it more cost effective to dispose of them than to clean the conventional manifolds. The sensor mount accommodates a removable sensor, and isolates it from the fluid path.
Abstract translation: 提供了切向流过滤装置，其中衬垫设置在过滤元件和顶部和底部保持器或歧管之间。 内衬包括流动通道，入口和出口以及传感器支架。 衬垫由廉价的材料制成，因此在一次使用后是一次性的，使得它们比处理常规歧管更经济有效。 传感器座可容纳可移动的传感器，并将其与流体路径隔离。
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公开(公告)号：US09289703B2
公开(公告)日：2016-03-22
申请号：US13868372
申请日：2013-04-23
Applicant: EMD Millipore Corporation
Inventor： Martin Morrissey , Dennis Wong
CPC classification number: B01D35/14 , B01D61/20 , B01D63/084 , B01D2313/04 , B01D2313/23 , B01D2313/44 , B01D2313/54 , C02F2209/03 , G01L7/082 , G01N1/10 , G01N1/4005 , Y10T436/25 , Y10T436/25375
Abstract: Tangential flow filtration device is provided wherein liners are provided between the filtration element and the top and bottom holders or manifolds. The liners incorporate the flow channels and inlet and outlet ports, as well as a sensor mount. The liners are made of an inexpensive material and therefore are disposable after a single use, making it more cost effective to dispose of them than to clean the conventional manifolds. The sensor mount accommodates a removable sensor, and isolates it from the fluid path.
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公开(公告)号：US20130039382A1
公开(公告)日：2013-02-14
申请号：US13654595
申请日：2012-10-18
Applicant: EMD Millipore Corporation
Inventor： Aaron Burke , Michael Felo , Brian Pereira , Elias Noukas , Dennis Wong
IPC: G01N25/00
CPC classification number: F25D29/00 , A01N1/0263 , F25D2331/802 , F25D2400/28 , F25D2400/30 , F25D2600/06 , F25D2700/12 , Y10T29/53
Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.
Abstract translation: 本发明的生物容器提供了在生物药物材料的运输，冷冻和解冻期间遇到的许多问题的低成本，简单的解决方案。 本发明使得用户能够在低温过程期间监测每个生物药物容器的温度曲线，以便通过使用预先安装和预灭菌的温度传感器来确保每个生物容器内的材料的完整性。 在一些实施例中，传感器组件包括无线发射器，并且能够发送关于测量读数的信息。 在其他实施例中，传感器组件包括处理单元，其确定温度分布是否可接受。 在另一实施例中，包括指示器，使得处理单元可以指示生物药物材料是否已被适当地冷冻。 在其他实施例中，传感器组件还包括存储元件，其能够在冷冻过程期间存储各种参数。
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公开(公告)号：US20130038469A1
公开(公告)日：2013-02-14
申请号：US13654593
申请日：2012-10-18
Applicant: EMD Millipore Corporation
Inventor： Aaron Burke , Michael Felo , Brian Pereira , Elias Noukas , Dennis Wong
IPC: G08C19/00
CPC classification number: F25D29/00 , A01N1/0263 , F25D2331/802 , F25D2400/28 , F25D2400/30 , F25D2600/06 , F25D2700/12 , Y10T29/53
Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.
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