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公开(公告)号：US20220119759A1
公开(公告)日：2022-04-21
申请号：US17073465
申请日：2020-10-19
Applicant: EMD Millipore Corporation
Inventor： Ying Li , Alison Dupont , Amy Wood , Allyson Fournier , Akshat Gupta , Hiral Gami
IPC: C12M1/00
Abstract: A multi-stage TFF apparatus, comprising a bioreactor capable of holding cell culture media; a first stage TFF device in fluid communication with the bioreactor; a storage tank in fluid communication with the first stage TFF device; a first recirculating loop in fluid communication with the first stage TFF device and the bioreactor; a second stage TFF device, in fluid communication with and downstream from the storage tank; and a second recirculating loop in fluid communication with the second stage TFF device and the storage tank.
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公开(公告)号：US10723990B2
公开(公告)日：2020-07-28
申请号：US14782487
申请日：2014-03-17
Applicant: EMD Millipore Corporation
Inventor： Kara Der , Anne Hansen , James McSweeney , David Kraus , Jeffrey Pearsons , Amy Wood
Abstract: A container, such as a disposable or single use bioreactor, optionally having one or more inlets and one or more outlets and a mixer associated with the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The container includes a flexible baffle shaped and positioned within the container to improve mixing, particularly to improve low shear mixing. The baffle is positioned within the container so as to disrupt the vortex formed by the mixer, or prevent formation of a vortex. The baffle is shaped with both horizontal and vertical elements to enhance disruption of the vortex across the entire vessel height and provide homogeneous mixing throughout all operating volumes. In certain embodiments, the baffle is X-shaped.
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公开(公告)号：US20240367122A1
公开(公告)日：2024-11-07
申请号：US18687944
申请日：2022-11-16
Applicant: EMD Millipore Corporation
Inventor： Sualyneth Galarza , Anne Hansen , Amy Mei , Amy Wood , James J. Vigna , Marisa Maher
IPC: B01F27/2122 , B01F27/17 , B01F33/453
Abstract: A hollow shaft impeller (100) having a hollow impeller housing (120), a magnet (108), an impeller cap (102), an impeller retainer (106), and a plurality of impeller blades (134). The impeller housing has a hub (130) that defines an interior volume (128) and an impeller bore that provides access to the interior volume. The magnet may be sized to be disposed within the interior volume. The impeller cap may be removably coupled to the hollow impeller housing proximate to the impeller bore. The impeller retainer may be removably coupled to the magnet and sized to be disposed within the interior volume. The plurality of impeller blades may project from the hub. Optionally, fins (140) may be disposed on each of the plurality of impeller blades.
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Patent Agency Ranking
公开(公告)号：US20160244710A1
公开(公告)日：2016-08-25
申请号：US14915796
申请日：2014-10-03
Applicant: EMD MILLIPORE CORPORATION
Inventor： Amy Wood , Dave Kraus , Anne Hansen , Kara Der , James McSweeney
CPC classification number: C12M27/02 , B01F3/04269 , B01F3/04531 , B01F7/22 , B01F13/0863 , B01F15/0022 , B01F15/00344 , B01F15/0085 , B01F2003/04297 , B01F2003/04631 , B01F2003/04673 , B01F2215/0073 , C12M29/06 , C12Q3/00
Abstract: An aeration device, and containers or vessels incorporating the same. The aeration device can comprise a plurality of interchangeable aeration elements that can produce gas bubble of different sizes and deliver them to the contents of the container. Also disclosed are containers, such as a disposable or single-use container, optionally having one or more inlets and one or more outlets, an aeration device including a plurality of aeration elements, and a mixer to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The container can be a bioreactors and the aeration device controls the dissolved gas concentration content of the bioreactor contents, thereby facilitating proper growth of cell cultures in the bioreactor.
Abstract translation: 曝气装置，以及装有该装置的容器或容器。 曝气装置可以包括多个可互换曝气元件，其可以产生不同尺寸的气泡并将其输送到容器的内容物。 还公开了容器，例如一次性或一次性容器，可选地具有一个或多个入口和一个或多个出口，包括多个通气元件的曝气装置和用于引起混合，分散，均质化和/或 包含或添加到容器中的一种或多种成分的循环。 容器可以是生物反应器，曝气装置控制生物反应器内容物的溶解气体浓度含量，从而促进生物反应器中细胞培养物的适当生长。
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公开(公告)号：US20160040113A1
公开(公告)日：2016-02-11
申请号：US14782487
申请日：2014-03-17
Applicant: EMD Millipore Corporation
Inventor： Kara Der , Anne Hansen , James McSweeney , David Kraus , Jeffrey Pearsons , Amy Wood
Abstract: A container, such as a disposable or single use bioreactor, optionally having one or more inlets and one or more outlets and a mixer associated with the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The container includes a flexible baffle shaped and positioned within the container to improve mixing, particularly to improve low shear mixing. The baffle is positioned within the container so as to disrupt the vortex formed by the mixer, or prevent formation of a vortex. The baffle is shaped with both horizontal and vertical elements to enhance disruption of the vortex across the entire vessel height and provide homogeneous mixing throughout all operating volumes. In certain embodiments, the baffle is X-shaped.
Abstract translation: 一个容器，例如一次性或单次使用的生物反应器，任选地具有一个或多个入口和一个或多个出口以及与该容器相关联的混合器，以使包含或添加到一个或多个成分中的一种或多种成分混合，分散，均化和/或循环 容器 容器包括形状并定位在容器内的柔性挡板以改善混合，特别是改善低剪切混合。 挡板位于容器内，以便破坏由混合器形成的涡流，或防止形成涡流。 挡板被成形为具有水平和垂直元件，以增强跨越整个容器高度的涡流的破坏，并在整个操作体积中提供均匀的混合。 在某些实施例中，挡板是X形的。
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公开(公告)号：US20240042398A1
公开(公告)日：2024-02-08
申请号：US18552525
申请日：2022-04-14
Applicant: EMD Millipore Corporation
Inventor： Marisa Maher , Stefano Berti Perez , Anne Hansen , Noah Rhein , Amy Mei , Sualyneth Galarza , John Caulmare , Joseph W. Muldoon , Amy Wood
IPC: B01F23/231 , B01F35/513
CPC classification number: B01F23/231241 , B01F23/231151 , B01F23/23125 , B01F23/231264 , B01F35/513 , B01F2101/44
Abstract: A multi-layered flexible sparger (100) that has a bottom film layer (102), a middle film layer (106), and a top film layer (110); a first inner mesh (104) disposed between the bottom film layer and the middle film layer; a second inner mesh (114) disposed between the middle film layer and the top film layer; and a port capable of delivering a gas to the multi-layered flexible sparger disposed between the top film layer and the bottom film layer, wherein the middle film layer comprises drill holes and the top film layer comprises drill holes.
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公开(公告)号：US20210355427A1
公开(公告)日：2021-11-18
申请号：US17312960
申请日：2020-03-26
Applicant: EMD MILLIPORE CORPORATION
Inventor： Anne Hansen , Kevin O'Brien , Amy Wood , Noah Rhein , Thomas Janko , Oliver Hiller
Abstract: A system for processing a biological fluid that includes a bioreactor, wherein the bioreactor includes a window, at least one port for allowing delivery of a processing aid; a control system, a sensor; a transmitter for transmitting the signal; a signal converter; a controller for receiving the signal; and a valve for delivering the processing aid to the port, wherein the sensor senses a process condition, transmits the signal, and the signal is compared with a reference signal and wherein a process action is optionally taken based on the comparison.
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公开(公告)号：US20210054327A1
公开(公告)日：2021-02-25
申请号：US16964646
申请日：2019-03-13
Applicant: EMD Millipore Corporation
Inventor： Jeffrey Pearsons , Amy Wood , David Kraus
Abstract: A collapsible container for a fluid that includes a flexible material, defining an internal working volume; at least one collapsible baffle adhered within the working volume of said collapsible container, the at least one baffle having one or more channels for delivering one or more fluids into the working volume via at least one hole in said one or more channels, one or more channels in said container for exiting or venting fluids from the working volume, and an impeller assembly disposed at least partially within said working volume of said container.
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