-
公开(公告)号：US11841361B2
公开(公告)日：2023-12-12
申请号：US17406732
申请日：2021-08-19
申请人： EMULATE, INC.
发明人： Kyung-Jin Jang , Janey Ronxhi , Josiah Sliz , Sauveur Jeanty , Sushma Jadalannagari , Ananth Nookala , Hyoungshin Park
CPC分类号： G01N33/5088 , C12N5/0684 , C12N5/0691 , C12N5/0697 , G01N33/5014 , G01N33/5044 , G01N33/5064
摘要： The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
-
公开(公告)号：US20200270582A1
公开(公告)日：2020-08-27
申请号：US16454753
申请日：2019-06-27
申请人： EMULATE, INC.
发明人： Kyung-Jin Jang , Hyoungshin Park , Sauveur Jeanty , Janey Ronxhi , Sushma jadalannagari , Geraldine A. Hamilton , Catherine Karalis
摘要： The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
-
公开(公告)号：US11725190B2
公开(公告)日：2023-08-15
申请号：US16454753
申请日：2019-06-27
申请人： EMULATE, INC.
发明人： Kyung-Jin Jang , Hyoungshin Park , Sauveur Jeanty , Janey Ronxhi , Sushma Jadalannagari , Geraldine A Hamilton , Catherine Karalis
CPC分类号： C12N5/0697 , B01L3/502715 , C12M23/16 , C12M25/02 , C12N5/0684 , C12N5/0691 , C12Q1/32 , G01N33/5005 , G01N33/5014 , G01N33/5082 , B01L2200/0652 , B01L2200/10
摘要： The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
-
公开(公告)号：US20230159899A1
公开(公告)日：2023-05-25
申请号：US17992168
申请日：2022-11-22
申请人： EMULATE, INC.
发明人： Geraldine Hamilton , Kyung Jin Jang , Suzzette Haney , Janey Ronxhi , Konstantia Kodella , Hyoungshin Park , Josiah Sliz , Debora Barreiros Petropolis , Daniel Levner , Monicah Otieno
CPC分类号： C12N5/067 , A61K35/407 , C12M23/16 , C12M25/02 , B01L3/5027 , C12M21/08 , C12N2502/28 , C12N2533/52 , C12N2533/90 , C12M25/14 , C12N5/0068
摘要： Provided herein relates to devices for simulating a function of a tissue and methods of using the same. In some embodiments, the devices can be used to simulate a function of a human liver tissue. In some embodiments, the devices can be used to simulate a function of a dog liver tissue. Endothelial cell culture media for long-term culture of endothelial cells are also described herein.
-
公开(公告)号：US20190093077A1
公开(公告)日：2019-03-28
申请号：US15781423
申请日：2016-12-02
申请人： EMULATE, INC.
发明人： Geraldine Hamilton , Kyung Jin Jang , Suzzette Haney , Janey Ronxhi , Konstantia Kodella , Hyoungshin Park , Josiah Sliz , Debora Barreiros Petropolis , Daniel Levner
摘要： Provided herein relates to devices for simulating a function of a tissue and methods of using the same. In some embodiments, the devices can be used to simulate a function of a human liver tissue. In some embodiments, the devices can be used to simulate a function of a dog liver tissue. Endothelial cell culture media for long-term culture of endothelial cells are also described herein.
-
-
-
-
搜索结果
5 条记录 (耗时 0.02 秒)
