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公开(公告)号：US20240036033A1
公开(公告)日：2024-02-01
申请号：US18474875
申请日：2023-09-26
申请人： EMULATE, INC.
发明人： Kyung-Jin Jang , Jamey Ronxhi , Josiah Sliz , Sauveur Jeanty , Sushma Jadalannagari , Ananth Nookala , Hyoungshin Park
CPC分类号： G01N33/5088 , C12N5/0684 , C12N5/0691 , G01N33/5064 , G01N33/5014 , G01N33/5044 , C12N5/0697
摘要： The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
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公开(公告)号：US11725190B2
公开(公告)日：2023-08-15
申请号：US16454753
申请日：2019-06-27
申请人： EMULATE, INC.
发明人： Kyung-Jin Jang , Hyoungshin Park , Sauveur Jeanty , Janey Ronxhi , Sushma Jadalannagari , Geraldine A Hamilton , Catherine Karalis
CPC分类号： C12N5/0697 , B01L3/502715 , C12M23/16 , C12M25/02 , C12N5/0684 , C12N5/0691 , C12Q1/32 , G01N33/5005 , G01N33/5014 , G01N33/5082 , B01L2200/0652 , B01L2200/10
摘要： The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
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公开(公告)号：US11534753B2
公开(公告)日：2022-12-27
申请号：US16352234
申请日：2019-03-13
申请人： EMULATE, Inc.
发明人： Ville Kujala , Hyoungshin Park , Sonalee Barthakur , Sauveur Jeanty , Brian Zuckerman , Josiah Sliz , Tanvi Shroff , Geraldine A Hamilton , Kyung-Jin Jang , Ananth Nookala , Gang Luo , Donald Mckenzie
IPC分类号： B01L3/00 , C12M3/06 , C12Q1/6809 , G01N33/50 , C12M1/12
摘要： The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.
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公开(公告)号：US20200269234A1
公开(公告)日：2020-08-27
申请号：US16352234
申请日：2019-03-13
申请人： EMULATE, Inc.
发明人： Ville Kujala , Hyoungshin Park , Sonalee Barthakur , Sauveur Jeanty , Brian Zuckerman , Josiah Sliz , Tanvi Shroff , Geraldine A. Hamilton , Kyung-Jin Jang , Ananth Nookala , Gang Luo , Donald Mckenzie
摘要： The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.
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公开(公告)号：US11841361B2
公开(公告)日：2023-12-12
申请号：US17406732
申请日：2021-08-19
申请人： EMULATE, INC.
发明人： Kyung-Jin Jang , Janey Ronxhi , Josiah Sliz , Sauveur Jeanty , Sushma Jadalannagari , Ananth Nookala , Hyoungshin Park
CPC分类号： G01N33/5088 , C12N5/0684 , C12N5/0691 , C12N5/0697 , G01N33/5014 , G01N33/5044 , G01N33/5064
摘要： The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
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公开(公告)号：US20200270582A1
公开(公告)日：2020-08-27
申请号：US16454753
申请日：2019-06-27
申请人： EMULATE, INC.
发明人： Kyung-Jin Jang , Hyoungshin Park , Sauveur Jeanty , Janey Ronxhi , Sushma jadalannagari , Geraldine A. Hamilton , Catherine Karalis
摘要： The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
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