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公开(公告)号：US10273441B2
公开(公告)日：2019-04-30
申请号：US15248633
申请日：2016-08-26
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson, II , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy , Joshua Gomes , Norman Wen , Jacob Freake , Doug Sabin
IPC分类号： C12M1/34 , C12M1/36 , A01N1/02 , C12M3/06 , B01L3/00 , C12M1/00 , C12M1/42 , C12N5/071 , C12M3/00 , B01L9/00
摘要： The invention relates to a perfusion manifold assembly that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with an assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. The invention further relates to a drop-to-drop connection scheme for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
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公开(公告)号：US20190112566A1
公开(公告)日：2019-04-18
申请号：US16221681
申请日：2018-12-17
申请人： EMULATE, Inc.
发明人： Christopher David Hinojosa , Guy Robert Thompson, II , Joshua Gomes , Jacob Freake , Doug Sabin
IPC分类号： C12M3/06 , C12M1/00 , B01L9/00 , A01N1/02 , C12M1/42 , C12M1/34 , B01L3/00 , C12M3/00 , C12N5/071 , C12M1/36
摘要： A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.
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公开(公告)号：US20220403312A9
公开(公告)日：2022-12-22
申请号：US16730448
申请日：2019-12-30
申请人： EMULATE, Inc.
IPC分类号： C12M3/06 , B01L9/00 , C12M1/36 , C12M3/00 , C12M1/00 , B01L3/00 , A01N1/02 , C12N5/071 , C12M1/34 , C12M1/42
摘要： A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.
A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.-
公开(公告)号：US10988722B2
公开(公告)日：2021-04-27
申请号：US16226229
申请日：2018-12-19
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson, II , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy , Joshua Gomes , Norman Wen , Jacob Freake , Doug Sabin
IPC分类号： C12M3/06 , C12M1/00 , B01L3/00 , C12M1/42 , C12M1/34 , C12N5/071 , A01N1/02 , C12M3/00 , C12M1/36 , B01L9/00
摘要： The invention relates to a perfusion manifold assembly that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with an assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.
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公开(公告)号：US10233416B2
公开(公告)日：2019-03-19
申请号：US15248690
申请日：2016-08-26
申请人： EMULATE, Inc.
发明人： Christopher David Hinojosa , Guy Robert Thompson, II , Joshua Gomes , Jacob Freake , Doug Sabin
IPC分类号： G01N1/00 , C12M3/06 , B01L3/00 , C12M1/00 , C12M1/42 , C12M1/34 , C12N5/071 , A01N1/02 , C12M3/00 , C12M1/36
摘要： A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.
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公开(公告)号：US20170055522A1
公开(公告)日：2017-03-02
申请号：US15248633
申请日：2016-08-26
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy , Joshua Gomes , Norman Wen , Jacob Freake , Doug Sabin
CPC分类号： C12M23/16 , A01N1/021 , A01N1/0247 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/025 , B01L2200/027 , B01L2200/12 , B01L2300/0681 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/161 , B01L2300/165 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , C12M21/08 , C12M23/38 , C12M23/40 , C12M23/42 , C12M29/10 , C12M35/04 , C12M41/40 , C12M41/48 , C12N5/0602 , C12N2521/00
摘要： A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
摘要翻译： 描述了用于将微流体装置与流体源或另一微流体装置流体连通的液滴连接方案，包括但不限于将微流体装置与灌注歧管组件流体连通。
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公开(公告)号：US11820966B2
公开(公告)日：2023-11-21
申请号：US16730448
申请日：2019-12-30
申请人： EMULATE, Inc.
发明人： Christopher David Hinojosa , Guy Robert Thompson, II , Joshua Gomes , Jacob Freake , Doug Sabin
IPC分类号： A01N1/00 , C12M3/06 , B01L3/00 , C12M1/00 , C12M1/42 , C12M1/34 , C12N5/071 , A01N1/02 , C12M3/00 , C12M1/36 , B01L9/00
CPC分类号： C12M23/16 , A01N1/021 , A01N1/0247 , B01L3/50273 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L9/527 , C12M21/08 , C12M23/38 , C12M23/40 , C12M23/42 , C12M29/10 , C12M35/04 , C12M41/40 , C12M41/48 , C12N5/0602 , B01L2200/025 , B01L2200/027 , B01L2200/12 , B01L2300/0681 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/161 , B01L2300/165 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , C12N2521/00
摘要： A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.
A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.-
公开(公告)号：US10519410B2
公开(公告)日：2019-12-31
申请号：US16221681
申请日：2018-12-17
申请人： EMULATE, Inc.
发明人： Christopher David Hinojosa , Guy Robert Thompson, II , Joshua Gomes , Jacob Freake , Doug Sabin
IPC分类号： G01N1/00 , C12M3/06 , B01L3/00 , C12M1/00 , C12M1/42 , C12M1/34 , C12N5/071 , A01N1/02 , C12M3/00 , C12M1/36 , B01L9/00
摘要： A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.
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公开(公告)号：US20190169557A1
公开(公告)日：2019-06-06
申请号：US16226229
申请日：2018-12-19
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson, II , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy , Joshua Gomes , Norman Wen , Jacob Freake , Doug Sabin
IPC分类号： C12M3/06 , C12M1/00 , B01L9/00 , A01N1/02 , C12M1/42 , C12M1/34 , B01L3/00 , C12M3/00 , C12N5/071 , C12M1/36
摘要： A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
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公开(公告)号：US20170058248A1
公开(公告)日：2017-03-02
申请号：US15248690
申请日：2016-08-26
申请人： EMULATE, Inc.
CPC分类号： C12M23/16 , A01N1/021 , A01N1/0247 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/025 , B01L2200/027 , B01L2200/12 , B01L2300/0681 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/161 , B01L2300/165 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , C12M21/08 , C12M23/38 , C12M23/40 , C12M23/42 , C12M29/10 , C12M35/04 , C12M41/40 , C12M41/48 , C12N5/0602 , C12N2521/00
摘要： A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.
摘要翻译： 可以设想一种培养模块，其允许一个或多个微流体装置的灌注和任选的机械致动，例如包含模拟体内器官的至少一个功能的细胞的片上微器件微流体装置。
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