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公开(公告)号：US11141727B2
公开(公告)日：2021-10-12
申请号：US15647831
申请日：2017-07-12
Applicant: EMULATE, Inc.
Inventor： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Joshua Gomes , Kyung Jin Jang
Abstract: Methods of removing bubbles from a microfluidic device are described where the flow is not stopped. Methods are described that combine pressure and flow to remove bubbles from a microfluidic device. Bubbles can be removed even where the device is made of a polymer that is largely gas impermeable.
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公开(公告)号：US11065620B2
公开(公告)日：2021-07-20
申请号：US15647762
申请日：2017-07-12
Applicant: EMULATE, Inc.
Inventor： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Joshua Gomes , Kyung Jin Jang
Abstract: Methods of removing bubbles from a microfluidic device are described where the flow is not stopped. Methods are described that combine pressure and flow to remove bubbles from a microfluidic device. Bubbles can be removed even where the device is made of a polymer that is largely gas impermeable.
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公开(公告)号：US10335788B2
公开(公告)日：2019-07-02
申请号：US15647800
申请日：2017-07-12
Applicant: EMULATE, Inc.
Inventor： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Joshua Gomes , Kyung Jin Jang
Abstract: Methods of removing bubbles from a microfluidic device are described where the flow is not stopped. Methods are described that combine pressure and flow to remove bubbles from a microfluidic device. Bubbles can be removed even where the device is made of a polymer that is largely gas impermeable.
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公开(公告)号：US20190169557A1
公开(公告)日：2019-06-06
申请号：US16226229
申请日：2018-12-19
Applicant: EMULATE, Inc.
Inventor： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson, II , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy , Joshua Gomes , Norman Wen , Jacob Freake , Doug Sabin
IPC: C12M3/06 , C12M1/00 , B01L9/00 , A01N1/02 , C12M1/42 , C12M1/34 , B01L3/00 , C12M3/00 , C12N5/071 , C12M1/36
Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
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公开(公告)号：US20180016535A1
公开(公告)日：2018-01-18
申请号：US15647762
申请日：2017-07-12
Applicant: EMULATE, Inc.
Inventor： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Joshua Gomes , Kyung Jin Jang
Abstract: Methods of removing bubbles from a microfluidic device are described where the flow is not stopped. Methods are described that combine pressure and flow to remove bubbles from a microfluidic device. Bubbles can be removed even where the device is made of a polymer that is largely gas impermeable.
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Patent Agency Ranking
公开(公告)号：US20210179992A1
公开(公告)日：2021-06-17
申请号：US17176873
申请日：2021-02-16
Applicant: EMULATE, Inc.
Inventor： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Joshua Gomes , Jose Fernandez-Alcon
IPC: C12M3/06 , B01L3/00 , C12M1/00 , C12M1/42 , C12M1/34 , C12N5/071 , A01N1/02 , C12M3/00 , C12M1/36 , B01L9/00
Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.
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公开(公告)号：US10913924B2
公开(公告)日：2021-02-09
申请号：US16152908
申请日：2018-10-05
Applicant: EMULATE, Inc.
Inventor： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Joshua Gomes , Jose Fernandez-Alcon
IPC: B01L3/00 , A61J1/06 , C12M3/06 , C12M1/00 , C12M1/42 , C12M1/34 , C12N5/071 , A01N1/02 , C12M3/00 , C12M1/36 , B01L9/00
Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.
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公开(公告)号：US20190040348A1
公开(公告)日：2019-02-07
申请号：US16152847
申请日：2018-10-05
Applicant: EMULATE, Inc.
Inventor： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Joshua Gomes , Jose Fernandez-Alcon
IPC: C12M3/06 , A01N1/02 , C12M1/00 , B01L3/00 , C12M1/34 , C12M3/00 , C12M1/36 , C12M1/42 , C12N5/071
Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.
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公开(公告)号：US10125342B2
公开(公告)日：2018-11-13
申请号：US15248509
申请日：2016-08-26
Applicant: EMULATE, Inc.
Inventor： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson, II , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy
IPC: B01L3/00 , C12M1/00 , C12M3/00 , C12M3/06 , C12M1/42 , C12M1/34 , C12N5/071 , A01N1/02 , C12M1/36
Abstract: Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
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公开(公告)号：US20170058243A1
公开(公告)日：2017-03-02
申请号：US15248509
申请日：2016-08-26
Applicant: EMULATE, Inc.
Inventor： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy
CPC classification number: C12M23/16 , A01N1/021 , A01N1/0247 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/025 , B01L2200/027 , B01L2200/12 , B01L2300/0681 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/161 , B01L2300/165 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , C12M21/08 , C12M23/38 , C12M23/40 , C12M23/42 , C12M29/10 , C12M35/04 , C12M41/40 , C12M41/48 , C12N5/0602 , C12N2521/00
Abstract: Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
Abstract translation: 描述了用于将微流体装置与流体源或另一微流体装置流体连通的液滴连接方案，包括但不限于将微流体装置与灌注歧管组件流体连通。
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