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公开(公告)号：US20240254449A1
公开(公告)日：2024-08-01
申请号：US18626855
申请日：2024-04-04
发明人： S. Jordan Kerns , Norman Wen , Carol Lucchesi , Christopher David Hinojosa , Jacob Fraser , Jefferson Puerta , Geraldine Hamilton , Robert Barrett , Clive Svendsen , Daniel Levner , Stephen R. Targan , Michael Workman , Dhruv Sareen , Uthra Rajamani , Magdalena Kasendra
CPC分类号： C12N5/0679 , C12M21/08 , C12M23/16 , C12N5/0618 , C12N5/0696 , G01N33/5005 , C12N2501/11 , C12N2501/119 , C12N2501/13 , C12N2501/155 , C12N2501/16 , C12N2501/24 , C12N2501/25 , C12N2501/415 , C12N2501/998 , C12N2501/999 , C12N2506/45 , C12N2535/00
摘要： Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.
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公开(公告)号：US20220033757A1
公开(公告)日：2022-02-03
申请号：US17494221
申请日：2021-10-05
申请人： EMULATE, INC.
发明人： Daniel Levner , Christopher David Hinojosa , Norman Wen , Antonio Varone , Justin Nguyen , Lina Williamson , S. Jordan Kerns , Catherine Karalis , Geraldine Hamilton , Carol Lucchesi
IPC分类号： C12M1/42 , C12M3/06 , C12M1/12 , G01N33/50 , G01N33/543 , C12M1/00 , C12N5/0793 , C12N5/079 , C12N5/071 , C12N5/077
摘要： A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.
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公开(公告)号：US20190119618A1
公开(公告)日：2019-04-25
申请号：US16089220
申请日：2017-03-30
申请人： EMULATE, INC.
发明人： Geraldine Hamilton , Norman Wen , Catherine Karalis , Antonio Varone , Daniel Levner , Riccardo Barrile
摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.
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公开(公告)号：USD838864S1
公开(公告)日：2019-01-22
申请号：US29576817
申请日：2016-09-07
申请人： EMULATE, Inc.
设计人： Daniel Levner , Guy Robert Thompson, II , Norman Wen , Lewis Rowe
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公开(公告)号：US20180017583A1
公开(公告)日：2018-01-18
申请号：US15648029
申请日：2017-07-12
申请人： Emulate Inc. , JANSSEN BIOTECH, Inc
发明人： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC分类号： G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
摘要： Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20180017582A1
公开(公告)日：2018-01-18
申请号：US15648000
申请日：2017-07-12
发明人： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC分类号： G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
摘要： Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20180015455A1
公开(公告)日：2018-01-18
申请号：US15648049
申请日：2017-07-12
申请人： Emulate Inc. , JANSSEN BIOTECH, Inc
发明人： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC分类号： G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
摘要： Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US12091650B2
公开(公告)日：2024-09-17
申请号：US16286185
申请日：2019-02-26
发明人： S. Jordan Kerns , Norman Wen , Carolina Lucchesi , Christopher David Hinojosa , Jacob Fraser , Geraldine Hamilton , Gad Vatine , Samuel Sances , Clive Svendsen , Daniel Levner , Dhruv Sareen
CPC分类号： C12M23/16 , B01L3/502715 , C12M25/02 , C12N5/0068 , C12N5/0619 , C12N5/0622 , C12N5/069 , B01L2200/0647 , B01L2300/0861 , C12N2502/081 , C12N2502/28 , C12N2506/02 , C12N2506/45 , C12N2531/00 , C12N2539/00
摘要： The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
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公开(公告)号：US20220282221A1
公开(公告)日：2022-09-08
申请号：US17678485
申请日：2022-02-23
发明人： S. Jordan Kerns , Norman Wen , Carol Lucchesi , Christopher David Hinojosa , Jacob Fraser , Jefferson Puerta , Geraldine Hamilton , Robert Barrett , Clive Svendsen , Daniel Levner , Stephen R. Targan , Michael Workman , Dhruv Sareen , Uthra Rajamani , Magdalena Kasendra
摘要： Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.
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公开(公告)号：US20220155328A1
公开(公告)日：2022-05-19
申请号：US17538518
申请日：2021-11-30
申请人： EMULATE, Inc.
发明人： JOSIAH SLIZ , Daniel Levner , Brian Zuckerman , Norman Wen , Jonathan Rubins , Tanvi Shroff , Christopher David Hinojosa , Grace Ahn , Victor Antontsev , Jefferson Puerta , David Conegliano , S. Jordan Kerns
摘要： The present invention is related to the field of microfluidics and compound distribution within microfluidic devices and their associated systems. In one embodiment, present invention aims to solve the problem of molecule and compound absorbency into the materials making up laboratory equipment, microfluidic devices and their related infrastructure, without unduly restricting gas transport within microfluidic devices.
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