公开(公告)号：US20180187211A1

公开(公告)日：2018-07-05

申请号：US15542005

申请日：2016-01-07

申请人： Frank R. JONES ,  Elizabeth GABITZSCH ,  Yvette LATCHMAN ,  Adrian RICE ,  Etubics Corporation

发明人： Frank R. Jones ,  Elizabeth Gabitzsch ,  Yvette Latchman ,  Adrian Rice

IPC分类号： C12N15/86 ,  A61K39/00 ,  A61P35/00 ,  A61P35/04 ,  C12N7/00 ,  C07K14/705 ,  C07K14/47 ,  A61K45/06 ,  A61K39/395 ,  A61P31/20

CPC分类号： C12N15/86 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/235 ,  A61K39/39541 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/575 ,  A61K2039/585 ,  A61K2039/70 ,  A61P31/20 ,  A61P35/00 ,  A61P35/04 ,  C07K14/4705 ,  C07K14/70596 ,  C07K16/2818 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/10023 ,  C12N2710/10043 ,  C12N2710/10071 ,  C12N2710/10343 ,  C12N2710/10371 ,  C12N2710/20034 ,  A61K2300/00

摘要： Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.

公开(公告)号：US11149087B2

公开(公告)日：2021-10-19

申请号：US15564413

申请日：2016-04-20

申请人： Etubics Corporation

发明人： Frank R. Jones ,  Elizabeth Gabitzsch ,  Yvette Latchman ,  Adrian Rice

IPC分类号： C12N15/86 ,  A61K39/395 ,  C07K16/28 ,  C07K16/08 ,  C07K16/30 ,  A61K39/29 ,  A61K39/00 ,  A61K31/282 ,  A61K31/513 ,  A61K31/519 ,  A61K38/17 ,  A61K39/12

摘要： Methods and compositions for generating immune responses using adenovirus vectors that allow multiple vaccinations or in combination with other therapy and vaccinations in individuals with preexisting immunity to adenovirus are provided.

公开(公告)号：US11352642B2

公开(公告)日：2022-06-07

申请号：US15542005

申请日：2016-01-07

申请人： Etubics Corporation

发明人： Frank R. Jones ,  Elizabeth Gabitzsch ,  Yvette Latchman ,  Adrian Rice

IPC分类号： C12N15/63 ,  C12N15/86 ,  A61K39/00 ,  A61K39/235 ,  C07K16/28 ,  A61K39/12 ,  A61K39/395 ,  A61P31/20 ,  A61P35/04 ,  A61P35/00 ,  A61K45/06 ,  C07K14/47 ,  C07K14/705 ,  C12N7/00

摘要： Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.

公开(公告)号：US11304998B2

公开(公告)日：2022-04-19

申请号：US17240285

申请日：2021-04-26

申请人： ETUBICS CORPORATION

发明人： Frank R. Jones ,  Adrian Rice ,  Elizabeth Gabitzsch ,  Yvette Latchman ,  Joseph Balint

IPC分类号： A61K39/00 ,  A61P35/00 ,  A61K39/39 ,  C12N15/86

摘要： Methods and compositions for generating enhanced immune responses using adenovirus vectors that allow for multiple vaccinations in combination with an IL-15 superagonist complex in subjects in need thereof are provided.

公开(公告)号：US20210260175A1

公开(公告)日：2021-08-26

申请号：US17240285

申请日：2021-04-26

申请人： ETUBICS CORPORATION

发明人： Frank R. Jones ,  Adrian Rice ,  Elizabeth Gabitzsch ,  Yvette Latchman ,  Joseph Balint

IPC分类号： A61K39/00 ,  A61P35/00 ,  A61K39/39 ,  C12N15/86

摘要： Methods and compositions for generating enhanced immune responses using adenovirus vectors that allow for multiple vaccinations in combination with an IL-15 superagonist complex in subjects in need thereof are provided.

公开(公告)号：US20190022209A1

公开(公告)日：2019-01-24

申请号：US16070104

申请日：2017-01-13

申请人： ETUBICS CORPORATION

发明人： Frank R. Jones ,  Joseph Balint ,  Elizabeth Gabitzsch ,  Yvette Latchman ,  Adrian Rice

IPC分类号： A61K39/145

摘要： Methods for constructing and producing a recombinant adenovirus based vector vaccine containing multiple influenza antigen genes for use in generating broad based immune responses against influenza A and B viruses and that allows for multiple vaccinations in individuals with preexisting immunity to adenovirus are described. Specifically, the recombinant adenovirus based vector is a replication defective adenovirus vector comprising a deletion in an early 2b (E2b) gene.

公开(公告)号：US20190030151A1

公开(公告)日：2019-01-31

申请号：US16070201

申请日：2017-01-13

申请人： ETUBICS CORPORATION

发明人： Frank R. Jones ,  Elizabeth Gabitzsch ,  Yvette Latchman ,  Adrian Rice

IPC分类号： A61K39/00 ,  C12N5/0783 ,  C07K16/30 ,  C07K14/705 ,  C07K14/725 ,  A61K45/06 ,  A61P35/00

摘要： Genetically modified compositions, such as adenoviral vectors and T cells, for treating diseases such as cancer and infectious diseases are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating diseases such as cancer and infectious diseases.

公开(公告)号：US11104916B2

公开(公告)日：2021-08-31

申请号：US16317747

申请日：2017-07-14

申请人： ETUBICS CORPORATION

发明人： Frank R. Jones ,  Joseph Balint ,  Adrian Rice ,  Yvette Latchman ,  Elizabeth Gabitzsch

IPC分类号： A61P31/14 ,  C12N15/86 ,  A61K39/12 ,  C12N7/00 ,  A61K39/00

摘要： Compositions of a recombinant adenovirus based vector vaccine containing one or more alphavirus antigen genes are disclosed herein. Methods for constructing and producing such vaccines and methods of using these vaccines to generate broad based immune responses against alphaviruses are also described. Compositions described herein allow for vaccinations in individuals with preexisting immunity to adenovirus.

公开(公告)号：US11020467B2

公开(公告)日：2021-06-01

申请号：US16614909

申请日：2018-05-25

申请人： ETUBICS CORPORATION

发明人： Frank R. Jones ,  Adrian Rice ,  Elizabeth Gabitzsch ,  Yvette Latchman ,  Joseph Balint

IPC分类号： A61K39/00 ,  A61P35/00 ,  A61K39/39 ,  C12N15/86

摘要： Methods and compositions for generating enhanced immune responses using adenovirus vectors that allow for multiple vaccinations in combination with an IL-15 superagonist complex in subjects in need thereof are provided.