METHODS AND COMPOSITIONS FOR INFLUENZA VACCINATION

    公开(公告)号:US20190022209A1

    公开(公告)日:2019-01-24

    申请号:US16070104

    申请日:2017-01-13

    IPC分类号: A61K39/145

    摘要: Methods for constructing and producing a recombinant adenovirus based vector vaccine containing multiple influenza antigen genes for use in generating broad based immune responses against influenza A and B viruses and that allows for multiple vaccinations in individuals with preexisting immunity to adenovirus are described. Specifically, the recombinant adenovirus based vector is a replication defective adenovirus vector comprising a deletion in an early 2b (E2b) gene.