公开(公告)号：US5468465A

公开(公告)日：1995-11-21

申请号：US271921

申请日：1994-07-06

申请人： Edward A. Deutsch ,  Karen F. Deutsch ,  William P. Cacheris ,  William H. Ralston ,  David H. White ,  Dennis L. Nosco ,  Robert G. Wolfangel ,  Janet B. Wilking ,  Linda Meeh ,  Steven R. Woulfe

发明人： Edward A. Deutsch ,  Karen F. Deutsch ,  William P. Cacheris ,  William H. Ralston ,  David H. White ,  Dennis L. Nosco ,  Robert G. Wolfangel ,  Janet B. Wilking ,  Linda Meeh ,  Steven R. Woulfe

IPC分类号： A61B5/055 ,  A61B19/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  C01B25/32 ,  C01G28/00 ,  C01G31/00 ,  C01G45/00 ,  C07F9/38

CPC分类号： A61K49/225 ,  A61K47/48861 ,  A61K49/1818 ,  A61K49/183 ,  A61K49/1842 ,  A61K49/1881 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B90/39 ,  Y10S977/722 ,  Y10S977/775 ,  Y10S977/881 ,  Y10S977/91 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93 ,  Y10T436/24

摘要： Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging (37 MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the abovedescribed apatite particles and then performing the medical diagnostic procedure.

摘要翻译： 公开了治疗磷灰石颗粒，用于增强诸如磁共振成像（“MRI”），磁共振光谱学（“MRS”），磁共振光谱成像（37MRSI“），X射线诊断成像和超声成像的医学诊断成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏，胃肠道或组织疾病状态的器官特异性成像的组合物。根据诊断成像技术，将磷灰石颗粒处理为 磷灰石颗粒也可以被氟化以形成用于19F成像的稳定的氟磷灰石组合物。还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的 上述磷灰石颗粒，然后执行药物 诊断程序。

公开(公告)号：US5609850A

公开(公告)日：1997-03-11

申请号：US518124

申请日：1995-08-22

申请人： Edward A. Deutsch ,  Karen F. Deutsch ,  William P. Cacheris ,  William H. Ralston ,  David H. White ,  Dennis L. Nosco ,  Robert G. Wolfangel ,  Janet B. Wilking ,  Linda Meeh ,  Steven R. Woulfe

发明人： Edward A. Deutsch ,  Karen F. Deutsch ,  William P. Cacheris ,  William H. Ralston ,  David H. White ,  Dennis L. Nosco ,  Robert G. Wolfangel ,  Janet B. Wilking ,  Linda Meeh ,  Steven R. Woulfe

IPC分类号： A61B5/055 ,  A61B19/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  C01B25/32 ,  C01G28/00 ,  C01G31/00 ,  C01G45/00 ,  C07F9/38 ,  A61B8/13

CPC分类号： A61K49/225 ,  A61K47/48861 ,  A61K49/1818 ,  A61K49/183 ,  A61K49/1842 ,  A61K49/1881 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B90/39 ,  Y10S977/722 ,  Y10S977/775 ,  Y10S977/881 ,  Y10S977/91 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93 ,  Y10T436/24

摘要： Treated apatite particles are disclosed for enhancing radical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the abovedescribed apatite particles and then performing the medical diagnostic procedure.

摘要翻译： 公开了处理的磷灰石颗粒，用于增强诸如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像和超声成像的基础诊断成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏，胃肠道或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，磷灰石颗粒被治疗为顺磁性，不透射线或回声。 磷灰石颗粒也可以被氟化以形成用于19F成像的稳定的氟磷灰石组合物。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述磷灰石颗粒，然后执行医学诊断程序。

公开(公告)号：US5595724A

公开(公告)日：1997-01-21

申请号：US373152

申请日：1995-01-13

申请人： Edward A. Deutsch ,  Karen F. Deutsch ,  Dennis L. Nosco ,  William H. Ralston ,  David H. White ,  Janet B. Wilking ,  Robert G. Wolfangel ,  Steven R. Woulfe ,  William P. Cacheris ,  Linda Meeh

发明人： Edward A. Deutsch ,  Karen F. Deutsch ,  Dennis L. Nosco ,  William H. Ralston ,  David H. White ,  Janet B. Wilking ,  Robert G. Wolfangel ,  Steven R. Woulfe ,  William P. Cacheris ,  Linda Meeh

IPC分类号： A61B5/055 ,  A61B8/00 ,  A61B19/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61K51/00 ,  A61K51/12 ,  C01B25/32 ,  C01G28/00 ,  C01G31/00 ,  C01G45/00 ,  C07F9/38 ,  G01R33/28

CPC分类号： A61K51/1241 ,  A61K47/48861 ,  A61K49/0414 ,  A61K49/1818 ,  A61K49/1842 ,  A61K49/1878 ,  A61K49/1881 ,  A61K49/225 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B90/39 ,  G01R33/281 ,  Y10S977/722 ,  Y10S977/881 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93 ,  Y10T436/24

摘要： Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.

摘要翻译： 公开了用于增强医学诊断成像例如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像， 和超声成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，含钙/含氧阴离子的颗粒被处理为顺磁性，不透射线的或回声的。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述颗粒，然后进行医学诊断程序。

公开(公告)号：US5344640A

公开(公告)日：1994-09-06

申请号：US948540

申请日：1992-09-22

申请人： Edward A. Deutsch ,  Karen F. Deutsch ,  William P. Cacheris ,  William H. Ralston ,  David H. White ,  Dennis L. Nosco ,  Robert G. Wolfangel ,  Janet B. Wilking ,  Linda Meeh ,  Steven R. Woulfe

发明人： Edward A. Deutsch ,  Karen F. Deutsch ,  William P. Cacheris ,  William H. Ralston ,  David H. White ,  Dennis L. Nosco ,  Robert G. Wolfangel ,  Janet B. Wilking ,  Linda Meeh ,  Steven R. Woulfe

IPC分类号： A61B5/055 ,  A61B19/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  C01B25/32 ,  C01G28/00 ,  C01G31/00 ,  C01G45/00 ,  C07F9/38

CPC分类号： A61K49/225 ,  A61K47/48861 ,  A61K49/1818 ,  A61K49/183 ,  A61K49/1842 ,  A61K49/1881 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B90/39 ,  Y10S977/722 ,  Y10S977/775 ,  Y10S977/881 ,  Y10S977/91 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93 ,  Y10T436/24

摘要： Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described apatite particles and then performing the medical diagnostic procedure.

摘要翻译： 公开了治疗磷灰石颗粒用于增强诸如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像和超声成像的医学诊断成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏，胃肠道或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，磷灰石颗粒被治疗为顺磁性，不透射线或回声。 磷灰石颗粒也可以被氟化以形成用于19F成像的稳定的氟磷灰石组合物。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述磷灰石颗粒，然后进行医学诊断程序。

公开(公告)号：US5407659A

公开(公告)日：1995-04-18

申请号：US47129

申请日：1993-04-13

申请人： Edward A. Deutsch ,  Karen F. Deutsch ,  Dennis L. Nosco ,  William H. Ralston ,  David H. White ,  Janet B. Wilking ,  Robert G. Wolfangel ,  Steven R. Woulfe

发明人： Edward A. Deutsch ,  Karen F. Deutsch ,  Dennis L. Nosco ,  William H. Ralston ,  David H. White ,  Janet B. Wilking ,  Robert G. Wolfangel ,  Steven R. Woulfe

IPC分类号： A61B5/055 ,  A61B8/00 ,  A61B19/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61K51/00 ,  A61K51/12 ,  C01B25/32 ,  C01G28/00 ,  C01G31/00 ,  C01G45/00 ,  C07F9/38 ,  G01R33/28

CPC分类号： A61K51/1241 ,  A61K47/48861 ,  A61K49/0414 ,  A61K49/1818 ,  A61K49/1842 ,  A61K49/1878 ,  A61K49/1881 ,  A61K49/225 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B90/39 ,  G01R33/281 ,  Y10S977/722 ,  Y10S977/881 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93 ,  Y10T436/24

摘要： Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.

摘要翻译： 公开了用于增强医学诊断成像例如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像， 和超声成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，含钙/含氧阴离子的颗粒被处理为顺磁性，不透射线的或回声的。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述颗粒，然后进行医学诊断程序。