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    Radionuclide labelled particles useful for radiation synovectomy
    7.
    发明授权
    Radionuclide labelled particles useful for radiation synovectomy 失效
    用于放射性滑膜切除术的放射性核素标记颗粒

    公开(公告)号：US5560901A

    公开(公告)日：1996-10-01

    申请号：US215332

    申请日：1994-03-21

    申请人： James W. Brodack ,  Edward A. Deutsch ,  Karen F. Deutsch ,  Dennis L. Nosco

    发明人： James W. Brodack ,  Edward A. Deutsch ,  Karen F. Deutsch ,  Dennis L. Nosco

    IPC分类号： A61K51/12 ,  A61K51/00

    CPC分类号： A61K51/1241 ,  A61K51/1255 ,  A61K2121/00

    摘要： The present invention provides radiation synovectomy compositions for treating inflamed synovium containing a radionuclide complex bound to a hydroxyapatite-like matrix as the radiolabelled synovectomy agent in a sufficient amount to provide satisfactory synovectomy of the inflamed synovium together with a pharmaceutically acceptable vehicle, the radionuclide being a beta emitter that will substantially ablate the inflamed synovium, but not significantly damage underlying articular cartilage, the radionuclide complex being substantially kinetically stable, and if said radionuclide or radionuclide complex leaks from said joint it will be excreted from the body, the agent having a particle size such that there is essentially little or no leakage of the radionuclide complex from the joint after administration.

    摘要翻译： 本发明提供辐射滑膜切除术组合物，用于治疗含有与羟磷灰石样基质结合的放射性核素复合物作为放射性标记的滑膜切除剂的发炎滑膜，其量足以提供发炎滑膜与药学上可接受的载体的令人满意的滑膜切除术，放射性核素是 β发射体将基本上消融发炎的滑膜，但不显着损伤关节软骨，放射性核素复合物基本上是动态稳定的，并且如果所述放射性核素或放射性核素复合物从所述接头泄漏，其将从体内排出， 尺寸，使得放射性核素复合物在给药后几乎几乎没有或没有从关节泄漏。

    Heavy metal clusters for use as imaging agents
    8.
    发明授权
    Heavy metal clusters for use as imaging agents 失效
    重金属簇用作成像剂

    公开(公告)号：US5417958A

    公开(公告)日：1995-05-23

    申请号：US190766

    申请日：1994-02-02

    申请人： Edward A. Deutsch ,  Karen F. Deutsch ,  Dennis L. Nosco

    发明人： Edward A. Deutsch ,  Karen F. Deutsch ,  Dennis L. Nosco

    IPC分类号： A61K49/04 ,  A61K49/06 ,  A61K49/18

    CPC分类号： A61K49/06 ,  A61K49/04 ,  A61K49/0433

    摘要： The present invention relates to novel compounds for use as imaging agents. In particular, the present invention relates to imaging agents comprising a heavy metal cluster having 2 to 8 atoms of the same of different heavy metal elements, and at least one coordinating ligand having 1 to 8 atoms which bond to the cluster, and a number of supporting atoms making up the framework of the ligand.

    摘要翻译： 本发明涉及用作成像剂的新型化合物。 特别地，本发明涉及包含具有不同重金属元素相同的2至8个原子的重金属簇和至少一个与该簇结合的具有1至8个原子的配位配体的成像剂，以及多个 支持构成配体框架的原子。

    Radionuclide labelled particles useful for radiation synovectomy
    9.
    发明授权
    Radionuclide labelled particles useful for radiation synovectomy 失效
    用于放射性滑膜切除术的放射性核素标记颗粒

    公开(公告)号：US5320824A

    公开(公告)日：1994-06-14

    申请号：US47322

    申请日：1993-04-16

    申请人： James W. Brodack ,  Edward A. Deutsch ,  Karen F. Deutsch ,  Dennis L. Nosco

    发明人： James W. Brodack ,  Edward A. Deutsch ,  Karen F. Deutsch ,  Dennis L. Nosco

    IPC分类号： A61K51/12 ,  A61K43/00 ,  A61N5/10

    CPC分类号： A61K51/1241 ,  A61K51/1255 ,  A61K2121/00

    摘要： The present invention provides radiation synovectomy compositions for treating inflamed synovium containing a radionuclide complex bound to a substantially insoluble particle as the radiolabelled synovectomy agent in a sufficient amount of provide satisfactory synovectomy of the inflamed synovium together with a pharmaceutically acceptable vehicle, the radionuclide being a beta emitter that will substantially ablate the inflamed synovium, but not significantly damage underlying articular cartilage, the radionuclide complex being substantially kinetically stable, and if said radionuclide or radionuclide complex leaks from said joint it will be excreted from the body, the agent having a particle size such that there is essentially little or no leakage of the radionuclide complex from the joint after administration.

    摘要翻译： 本发明提供了用于治疗发炎滑膜的放射性滑膜切除组合物，该组合物含有与实质上不溶性颗粒结合的放射性核素复合物作为放射性标记的滑膜切除剂，其量足以使得发炎的滑膜与药学上可接受的载体一起提供令人满意的滑膜切除术，放射性核素为β 发射器将基本上消融发炎的滑膜，但不显着损伤关节软骨，放射性核素复合物基本上是动态稳定的，并且如果所述放射性核素或放射性核素复合物从所述接头泄漏，则其将从体内排出， 使得放射性核素复合物在给药后几乎几乎没有或没有从关节泄漏。