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公开(公告)号：US20140044746A1
公开(公告)日：2014-02-13
申请号：US13978057
申请日：2012-01-06
IPC分类号： C07K14/005
CPC分类号： A61K39/21 , A61K39/12 , A61K39/145 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/572 , A61K2039/575 , A61K2039/6031 , A61K2039/62 , C07K14/005 , C12N7/00 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2760/16122 , C12N2760/16134 , C12N2770/24222 , C12N2770/24234
摘要： The present invention relates to novel peptides and methods for inducing an immune response in a subject against an antigen and for treatment, diagnosis and prognosis of infections or autoimmune diseases including infections with HCV, HIV, CMV and Flu. The invention further relates to methods for identifying and providing peptides useful for the treatment and diagnosis. X1—X2—X3—X4—X5—X6 (formula I)
摘要翻译： 本发明涉及用于针对抗原诱导受试者免疫应答的新型肽和方法，以及感染或自身免疫疾病（包括HCV，HIV，CMV和Flu感染）的治疗，诊断和预后。 本发明还涉及用于鉴定和提供可用于治疗和诊断的肽的方法。 X1-X2-X3-X4-X5-X6（式I）
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2.发明授权Peptide constructs derived from the GP120 C5 domain and GP41 transmembrane domain 有权衍生自GP120 C5结构域和GP41跨膜结构域的肽构建体公开(公告)号：US09200065B2
公开(公告)日：2015-12-01
申请号：US13382137
申请日：2010-07-03
申请人： Maja Sommerfelt Grønvold , Angus Dalgleish , Einar Tønnes Lange , Jens Olof Holmberg , Per Bengtsson , Birger Sørensen
发明人： Maja Sommerfelt Grønvold , Angus Dalgleish , Einar Tønnes Lange , Jens Olof Holmberg , Per Bengtsson , Birger Sørensen
IPC分类号： A61K39/21 , A61K39/12 , C07K16/10 , C07K14/005 , A61K39/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/505 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/627 , C07K14/005 , C07K16/1063 , C12N7/00 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171
摘要： Disclosed is a method for treatment of HIV related diseases comprising targeting complexes between on the one hand the C5 domain of gp120 and on the other hand gp41 or the C2 domain of gp120. The complexes may be stabilised by administering compounds, such as antibodies, capable of directly interacting with and stabilising the complex, or by immunizing with C5 and gp41/C2 derived material so as to induce antibodies that bind to and stabilise the complex.
摘要翻译： 公开了一种治疗HIV相关疾病的方法，其包括一方面靶向复合物，一方面是gp120的C5结构域，另一方面是gp41或gp120的C2结构域。 可以通过施用能够与复合体直接相互作用和稳定化合物的化合物，例如抗体，或通过用C5和gp41 / C2衍生的材料免疫以诱导结合并稳定复合物的抗体来稳定复合物。
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公开(公告)号：US09550811B2
公开(公告)日：2017-01-24
申请号：US13991108
申请日：2011-12-02
IPC分类号： A61K48/00 , A61K9/127 , C12N15/85 , C12P21/00 , A61K31/7115 , C07K14/005 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/29 , C07K7/08 , C12N15/87 , A61K39/00
CPC分类号： A61K39/245 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/29 , A61K48/0033 , A61K48/005 , A61K48/0066 , A61K2039/572 , C07K7/08 , C07K14/005 , C12N7/00 , C12N15/87 , C12N2710/16122 , C12N2710/16134 , C12N2710/20022 , C12N2710/20034 , C12N2740/16222 , C12N2740/16234 , C12N2760/16122 , C12N2760/16134 , C12N2770/24222 , C12N2770/24234
摘要： The present invention relates to novel peptides and methods for treatment, diagnosis and prognosis of virus infections including infections with HCV, HIV, CMV and Influenza. The invention further relates to methods for identifying and providing peptides useful for the treatment and diagnosis. X1-X2-X3-X4-X5 (I)
摘要翻译： 本发明涉及用于病毒感染的治疗，诊断和预后的新型肽和方法，包括HCV，HIV，CMV和流感的感染。 本发明还涉及鉴定和提供可用于治疗和诊断的肽的方法。 X1-X2-X3-X4-X5（I）
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公开(公告)号：US20130337002A1
公开(公告)日：2013-12-19
申请号：US13991108
申请日：2011-12-02
IPC分类号： C07K14/005 , C07K7/08
CPC分类号： A61K39/245 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/29 , A61K48/0033 , A61K48/005 , A61K48/0066 , A61K2039/572 , C07K7/08 , C07K14/005 , C12N7/00 , C12N15/87 , C12N2710/16122 , C12N2710/16134 , C12N2710/20022 , C12N2710/20034 , C12N2740/16222 , C12N2740/16234 , C12N2760/16122 , C12N2760/16134 , C12N2770/24222 , C12N2770/24234
摘要： The present invention relates to novel peptides and methods for treatment, diagnosis and prognosis of virus infections including infections with HCV, HIV, CMV and Influenza. The invention further relates to methods for identifying and providing peptides useful for the treatment and diagnosis. X1—X2—X3—X4—X5 (I)
摘要翻译： 本发明涉及用于病毒感染的治疗，诊断和预后的新型肽和方法，包括HCV，HIV，CMV和流感的感染。 本发明还涉及用于鉴定和提供可用于治疗和诊断的肽的方法。 X1-X2-X3-X4-X5（I）
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公开(公告)号：US20120263720A1
公开(公告)日：2012-10-18
申请号：US13382137
申请日：2010-07-03
申请人： Maja Sommerfelt Grønvold , Angus Dalgleish , Einar Tønnes Lange , Jens Olof Holmberg , Per Bengtsson , Birger Sørensen
发明人： Maja Sommerfelt Grønvold , Angus Dalgleish , Einar Tønnes Lange , Jens Olof Holmberg , Per Bengtsson , Birger Sørensen
IPC分类号： A61K39/21 , C12N15/12 , G01N21/55 , C12N15/63 , G01N33/566 , G01N27/72 , A61K39/42 , A61P31/18
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/505 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/627 , C07K14/005 , C07K16/1063 , C12N7/00 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171
摘要： Disclosed is a method for treatment of HIV related diseases comprising targeting complexes between on the one hand the C5 domain of gp120 and on the other hand gp41 or the C2 domain of gp120. The complexes may be stabilised by administering compounds, such as antibodies, capable of directly interacting with and stabilising the complex, or by immunizing with C5 and gp41/C2 derived material so as to induce antibodies that bind to and stabilise the complex.
摘要翻译： 公开了一种治疗HIV相关疾病的方法，其包括一方面靶向复合物，一方面是gp120的C5结构域，另一方面是gp41或gp120的C2结构域。 可以通过施用能够与复合体直接相互作用和稳定化合物的化合物，例如抗体，或通过用C5和gp41 / C2衍生的材料免疫以诱导结合并稳定复合物的抗体来稳定复合物。
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