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公开(公告)号：US10512769B2
公开(公告)日：2019-12-24
申请号：US13783319
申请日：2013-03-03
申请人： Electrocore, LLC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating or preventing an autism spectrum disorder, a pervasive developmental disorder, or a disorder of psychological development. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The nerve stimulation may be used as a behavior conditioning tool, by producing euphoria in an autistic individual. Vagus nerve stimulation is also used to modulate circulating serotonin levels in a pregnant woman so as to reduce the risk of having an autistic child; modulate the levels of growth factors within a child; promote balance of neuronal excitation/inhibition; modulate the activity of abnormal resting state neuronal networks; increase respiratory sinus arrhythmia; and avert episodes of motor stereotypies with the aid of forecasting methods.
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公开(公告)号：US10376696B2
公开(公告)日：2019-08-13
申请号：US15012689
申请日：2016-02-01
申请人： ElectroCore, LLC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a stimulator that is applied to the surface of the patient's neck. The device housing transmits data to a patient interface device such as a mobile phone or computer relating to the status of a stimulation session. The interface device in turn may communicate with a database contained within other computers, via a network or the internet. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.
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公开(公告)号：US10363415B2
公开(公告)日：2019-07-30
申请号：US15149406
申请日：2016-05-09
申请人： ElectroCore, LLC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.
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公开(公告)号：US10207106B2
公开(公告)日：2019-02-19
申请号：US14992398
申请日：2016-01-11
申请人： ElectroCore, LLC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The methods provide damaged interstitial cells of Cajal (ICC) with trophic factors via vagal afferent nerve fibers, thereby reversing ICC damage, and as a consequence improving gastric motility. The methods also increase levels of inhibitory neurotransmitters in the brain so as to decrease neural activity within the area postrema, or they deactivate a resting state neural network containing parts of the anterior insula and anterior cingulate cortex, which will thereby reduce abnormal interoception and visceral hypersensitivity.
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公开(公告)号：US20170120052A9
公开(公告)日：2017-05-04
申请号：US13655716
申请日：2012-10-19
申请人： Electrocore, LLC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC分类号： A61N1/36053 , A61B5/0476 , A61B5/4094 , A61B5/4833 , A61B5/4836 , A61N1/36003 , A61N1/36014 , A61N1/3756 , A61N1/40 , A61N2/006 , A61N2/02
摘要： Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of averting imminent medical attacks using energy that is delivered noninvasively by the devices. The attacks comprise asthma attack, epileptic seizure, attacks of migraine headache, transient ischemic attack or stroke, onset of atrial fibrillation, myocardial infarction, onset of ventricular fibrillation or tachycardia, panic attack, and attacks of acute depression. The imminence of an attack is forecasted using grey-box or black-box models as used in control theory. In preferred embodiments of the disclosed methods, a vagus nerve in the neck of a patient is stimulated noninvasively to avert the attack.
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6.发明授权Devices and methods for treating medical disorders with evoked potentials and vagus nerve stimulation 有权用诱发电位和迷走神经刺激治疗医学疾病的装置和方法公开(公告)号：US09427581B2
公开(公告)日：2016-08-30
申请号：US14212992
申请日：2014-03-14
申请人： ElectroCore, LLC
发明人： Bruce J. Simon , Joseph P. Errico
CPC分类号： A61N1/36021 , A61B5/02405 , A61B5/04886 , A61B5/4035 , A61B5/4041 , A61B5/4803 , A61B5/4836 , A61B5/7264 , A61B5/7267 , A61B2090/3941 , A61N1/0456 , A61N1/36014 , A61N1/40
摘要： Devices, systems and methods for treating medical disorders, such as migraine or other primary headaches, or fibromyalgia, by noninvasive electrical stimulation of a vagus nerve, used in conjunction with the measurement of evoked potentials (EPs). The system comprises a stimulator that is applied to the surface of the patient's neck to apply electrical impulses sufficient to stimulate a cervical vagus nerve, scalp electrodes that are used to measure EPs that are evoked by that stimulation, feedback or biofeedback circuits to vary the stimulation based upon EP characteristics, and other sensory stimulation modalities that produce EPs. The system is preferably used to optimize the placement of the stimulator, to test whether a patient is a suitable candidate for treatment using vagus nerve stimulation, and to select the stimulation parameters that optimized acute or chronic treatment, e.g., by correcting an EP habituation deficit.
摘要翻译： 用于与诱发电位（EP）的测量结合使用的用于通过无创电刺激迷走神经治疗医学病症如偏头痛或其它原发性头痛或纤维肌痛的装置，系统和方法。 该系统包括刺激器，其被施加到患者颈部的表面以施加足以刺激颈部迷走神经的电脉冲，用于测量由该刺激引起的EP的头皮电极，反馈或生物反馈电路以改变刺激 基于EP特征，以及产生EP的其它感觉刺激模式。 该系统优选用于优化刺激器的放置，以测试患者是否是使用迷走神经刺激治疗的合适候选者，并且选择优化急性或慢性治疗的刺激参数，例如通过校正EP习惯性缺陷 。
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公开(公告)号：US20160151628A1
公开(公告)日：2016-06-02
申请号：US15018805
申请日：2016-02-08
申请人： ElectroCore, LLC
发明人： Bruce J. Simon , Joseph P. Errico
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61B5/02405 , A61B5/04886 , A61B5/4035 , A61B5/4041 , A61B5/4803 , A61B5/4836 , A61B5/687 , A61B5/7264 , A61B5/7267 , A61B2090/3941 , A61N1/36021 , A61N1/40
摘要： Devices and methods are disclosed that treat a medical condition, such as migraine headache, by electrically stimulating a nerve noninvasively, which may be a vagus nerve situated within a patient's neck. Preferred embodiments allow a patient to self-treat his or her condition. Disclosed methods assure that the device is being positioned correctly on the neck and that the amplitude and other parameters of the stimulation actually stimulate the vagus nerve with a therapeutic waveform. Those methods comprise measuring properties of the patient's larynx, pupil diameters, blood flow within an eye, electrodermal activity and/or heart rate variability.
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公开(公告)号：US20160136423A1
公开(公告)日：2016-05-19
申请号：US15005904
申请日：2016-01-25
申请人： ElectroCore, LLC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC分类号： A61N1/36021 , A61M21/00 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61N1/0456 , A61N1/0496 , A61N1/36014 , A61N1/36025 , A61N1/36053 , A61N1/40
摘要： A non-invasive electrical stimulator shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in contact with the electrodes. The conducting medium is also in contact with an interface element that may conform to the contour of a target body surface of the patient when the interface element is applied to that surface. When the interface element is made of insulating (dielectric) material, and disclosed stimulation waveforms are used, the power source need not supply high voltage, in order to capacitively stimulate the target nerve. The stimulator produces a peak pulse that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve.
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9.发明申请公开(公告)号：US20160051820A1
公开(公告)日：2016-02-25
申请号：US14929734
申请日：2015-11-02
申请人： Electrocore, LLC
发明人： Bruce J. Simon , Joseph P. Errico
CPC分类号： A61N1/36075 , A61N1/0546 , A61N1/37205 , A61N1/37229 , A61N1/3787
摘要： Devices, systems and methods are disclosed for modulating cranial nerves, such as the sphenopalatine ganglion, to treat a medical condition of a patient, such as cluster headache. A stimulation device comprising a dipole antenna is advanced transnasally to a target site at or adjacent to the nasopharyngeal mucosa posterior to the middle turbinate. Electrical impulses are applied through one or more electrodes in the stimulation device to the target nerve sufficient to modulate the nerve and treat the medical condition.
摘要翻译： 公开了用于调节颅神经（例如蝶腭神经节）以治疗患者的医学状况的装置，系统和方法，例如丛集性头痛。 包括偶极天线的刺激装置在鼻甲后面的鼻咽粘膜上或邻近的鼻部位置经过鼻前进。 电脉冲通过刺激装置中的一个或多个电极施加到目标神经足以调节神经并治疗医疗状况。
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10.发明申请DEVICES AND METHODS FOR NON-INVASIVE CAPACITIVE ELECTRICAL STIMULATION AND THEIR USE FOR VAGUS NERVE STIMULATION ON THE NECK OF A PATIENT 有权非侵入性电刺激的装置和方法及其对患者NECK刺激的VAGUS神经刺激的使用公开(公告)号：US20150297889A1
公开(公告)日：2015-10-22
申请号：US14753160
申请日：2015-06-29
申请人： Electrocore, LLC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC分类号： A61N1/36021 , A61M21/00 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61N1/0456 , A61N1/0496 , A61N1/36014 , A61N1/36025 , A61N1/36053 , A61N1/40
摘要： A non-invasive electrical stimulator shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in contact with the electrodes. The conducting medium is also in contact with an interface element that may conform to the contour of a target body surface of the patient when the interface element is applied to that surface. When the interface element is made of insulating (dielectric) material, and disclosed stimulation waveforms are used, the power source need not supply high voltage, in order to capacitively stimulate the target nerve. The stimulator produces a peak pulse that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve.
摘要翻译： 非侵入式电刺激器形成可以平行于长神经（例如患者颈部的迷走神经）定向的细长电场，在患者体内产生所需的生理反应。 刺激器包括电源，至少一个电极和与电极接触的连续导电介质。 当将界面元件应用于该表面时，导电介质也与接口元件接触，该界面元件可以符合患者的目标体表的轮廓。 当界面元件由绝缘（电介质）材料制成并且使用公开的刺激波形时，电源不需要提供高电压，以便电容地刺激目标神经。 刺激器产生足以在目标神经附近产生生理有效电场的峰值脉冲。
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