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8 条记录 (耗时 0.019 秒)

    METHODS OF USING ZSCAN4 FOR REJUVENATING HUMAN CELLS
    2.
    发明申请
    METHODS OF USING ZSCAN4 FOR REJUVENATING HUMAN CELLS 审中-公开

    公开(公告)号：US20190282659A1

    公开(公告)日：2019-09-19

    申请号：US16427038

    申请日：2019-05-30

    申请人： Elixirgen Therapeutics, Inc.

    发明人： Minoru S.H. KO

    IPC分类号： A61K38/17 ,  A61K35/28 ,  A61K48/00 ,  C12N5/0735 ,  C12N5/075 ,  C12N5/074 ,  A61K31/7088 ,  C12N15/113 ,  A61K9/51 ,  C12Q1/6883 ,  C12N15/85 ,  A61K35/33 ,  A61K35/545

    摘要： The present disclosure relates to methods for increasing telomere length in one or more human cells and/or increasing genome stability of one or more human cells, for example by contacting one or more human cells with an agent that increases expression of Zscan4 in the one or more human cells. Methods of treating a subject in need of telomere lengthening, treating a disease or condition associated with a genomic and/or chromosome abnormality, of rejuvenating one or more human cells, of rejuvenating tissues or organs, and of rejuvenating a subject in need thereof, for example by contacting one or more human cells in the subject with an agent that increases expression of Zscan4, or by administering to a subject in need thereof, an agent that increases expression of Zscan4 are also provided.

    TEMPERATURE-BASED TRANSIENT DELIVERY OF NUCLEIC ACIDS AND PROTEINS TO CELLS AND TISSUES
    3.
    发明申请
    TEMPERATURE-BASED TRANSIENT DELIVERY OF NUCLEIC ACIDS AND PROTEINS TO CELLS AND TISSUES 有权

    公开(公告)号：US20220372518A1

    公开(公告)日：2022-11-24

    申请号：US17818314

    申请日：2022-08-08

    申请人： Elixirgen Therapeutics, Inc.

    发明人： Minoru S.H. KO

    IPC分类号： C12N15/86 ,  A61P31/14 ,  A61K9/00 ,  A61K39/215 ,  C12N7/00 ,  C12N15/113

    摘要： The present disclosure relates to methods for transiently activating temperature-sensitive agents in one or more cells, for example by contacting one or more cells with a temperature-sensitive agent and transiently incubating the cells at a permissive temperature for inducing an activity of the temperature-sensitive agent in the cells. Additionally, the present disclosure relates to methods of contacting one or more cells in a subject with a temperature-sensitive agent and then lowering the subject's core body temperature to a permissive temperature for inducing an activity of the temperature-sensitive agent in the cells. The disclosure also relates to methods of contacting one or more cells in a subject with a temperature-sensitive agent, maintaining the subject's surface body temperature at a permissive temperature for inducing an activity of the temperature-sensitive agent in the cells. Further disclosed are methods of treating a subject with a temperature-sensitive therapeutic agent.

    METHODS OF USING ZSCAN4 FOR REJUVENATING HUMAN CELLS
    4.
    发明申请
    METHODS OF USING ZSCAN4 FOR REJUVENATING HUMAN CELLS 审中-公开

    公开(公告)号：US20190282660A1

    公开(公告)日：2019-09-19

    申请号：US16427097

    申请日：2019-05-30

    申请人： Elixirgen Therapeutics, Inc.

    发明人： Minoru S.H. KO

    IPC分类号： A61K38/17 ,  A61K35/28 ,  A61K48/00 ,  C12N5/0735 ,  C12N5/075 ,  C12N5/074 ,  A61K31/7088 ,  C12N15/113 ,  A61K9/51 ,  C12Q1/6883 ,  C12N15/85 ,  A61K35/33 ,  A61K35/545

    摘要： The present disclosure relates to methods for increasing telomere length in one or more human cells and/or increasing genome stability of one or more human cells, for example by contacting one or more human cells with an agent that increases expression of Zscan4 in the one or more human cells. Methods of treating a subject in need of telomere lengthening, treating a disease or condition associated with a genomic and/or chromosome abnormality, of rejuvenating one or more human cells, of rejuvenating tissues or organs, and of rejuvenating a subject in need thereof, for example by contacting one or more human cells in the subject with an agent that increases expression of Zscan4, or by administering to a subject in need thereof, an agent that increases expression of Zscan4 are also provided.

    TEMPERATURE-BASED TRANSIENT DELIVERY OF NUCLEIC ACIDS AND PROTEINS TO CELLS AND TISSUES
    8.
    发明申请
    TEMPERATURE-BASED TRANSIENT DELIVERY OF NUCLEIC ACIDS AND PROTEINS TO CELLS AND TISSUES 有权

    公开(公告)号：US20210381005A1

    公开(公告)日：2021-12-09

    申请号：US17404901

    申请日：2021-08-17

    申请人： Elixirgen Therapeutics, Inc.

    发明人： Minoru S.H. KO

    IPC分类号： C12N15/86 ,  C12N7/00 ,  A61K39/215 ,  A61P31/14 ,  A61K9/00 ,  C12N15/113

    摘要： The present disclosure relates to methods for transiently activating temperature-sensitive agents in one or more cells, for example by contacting one or more cells with a temperature-sensitive agent and transiently incubating the cells at a permissive temperature for inducing an activity of the temperature-sensitive agent in the cells. Additionally, the present disclosure relates to methods of contacting one or more cells in a subject with a temperature-sensitive agent and then lowering the subject's core body temperature to a permissive temperature for inducing an activity of the temperature-sensitive agent in the cells. The disclosure also relates to methods of contacting one or more cells in a subject with a temperature-sensitive agent, maintaining the subject's surface body temperature at a permissive temperature for inducing an activity of the temperature-sensitive agent in the cells. Further disclosed are methods of treating a subject with a temperature-sensitive therapeutic agent.