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公开(公告)号：US20060223837A1
公开(公告)日：2006-10-05
申请号：US11387894
申请日：2006-03-23
申请人： Ellen Codd , Scott Dax , Christopher Flores , Michelle Jetter , Mark Youngman
发明人： Ellen Codd , Scott Dax , Christopher Flores , Michelle Jetter , Mark Youngman
IPC分类号： A61K31/506 , A61K31/4709 , A61K31/444 , C07D401/02
CPC分类号： C07D291/04 , C07C233/29 , C07C233/55 , C07C237/42 , C07D213/53 , C07D213/75 , C07D233/64 , C07D233/68 , C07D235/06 , C07D271/06 , C07D333/24 , C07D401/04 , C07D401/12
摘要： The invention is directed to novel vanilloid receptor type 1 (VR1) ligands. More specifically, the invention relates to novel biaryl-derived amides that are potent antagonists or agonists of VR1. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译： 本发明涉及新型香草素受体1型（VR1）配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的新型联芳基衍生的酰胺。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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2.发明申请公开(公告)号：US20080097102A1
公开(公告)日：2008-04-24
申请号：US11877220
申请日：2007-10-23
申请人： Ellen Codd , Scott Dax , Michele Jetter , Mark McDonnell , James McNally , Mark Youngman
发明人： Ellen Codd , Scott Dax , Michele Jetter , Mark McDonnell , James McNally , Mark Youngman
IPC分类号： C07D217/22 , C07C275/06
CPC分类号： C07D213/40 , C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07C2601/02 , C07C2602/10 , C07D215/38 , C07D217/02 , C07D217/08 , C07D217/22 , C07D217/24 , C07D233/64 , C07D237/28 , C07D239/74 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/32 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的β-氨基四氢萘衍生的脲，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。
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公开(公告)号：US20050187291A1
公开(公告)日：2005-08-25
申请号：US11045956
申请日：2005-01-28
申请人： Ellen Codd , Scott Dax , Michele Jetter , Mark McDonnell , James McNally , Mark Youngman
发明人： Ellen Codd , Scott Dax , Michele Jetter , Mark McDonnell , James McNally , Mark Youngman
IPC分类号： C07D233/64 , A61K31/17 , A61K31/36 , A61K31/4164 , A61K31/47 , A61K31/472 , A61P1/00 , A61P1/04 , A61P11/00 , A61P11/06 , A61P13/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P29/00 , A61P35/00 , A61P39/02 , A61P43/00 , C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07D213/40 , C07D215/38 , C07D217/02 , C07D217/08 , C07D217/22 , C07D217/24 , C07D233/54 , C07D237/28 , C07D239/74 , C07D307/52 , C07D317/58 , C07D317/66 , C07D333/20 , C07D333/32 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , A61K31/277 , A61K31/195
CPC分类号： C07D213/40 , C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07C2601/02 , C07C2602/10 , C07D215/38 , C07D217/02 , C07D217/08 , C07D217/22 , C07D217/24 , C07D233/64 , C07D237/28 , C07D239/74 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/32 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的β-氨基四氢萘衍生的脲，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。
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公开(公告)号：US20080027029A1
公开(公告)日：2008-01-31
申请号：US11746318
申请日：2007-05-09
申请人： Raymond Colburn , Scott Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark Youngman
发明人： Raymond Colburn , Scott Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark Youngman
IPC分类号： A61K31/67 , A61K31/665 , A61K31/675 , A61P25/00 , A61P29/00 , A61P9/00 , A61P9/12 , C07D495/00 , C07F9/572 , C07F9/655 , C07F9/6553
CPC分类号： C07F9/655354 , C07F9/5728 , C07F9/65517 , C07F9/65586 , C07F9/6561
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。
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5.发明申请公开(公告)号：US20080300236A1
公开(公告)日：2008-12-04
申请号：US12174017
申请日：2008-07-16
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： A61K31/47 , C07D215/38 , A61K31/55 , A61P9/00 , A61P25/00 , C07D401/14
CPC分类号： C07D215/38 , C07D215/60 , C07D401/12 , C07D405/12 , C07D409/12 , C07D491/10
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to quinoline-derived amides that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的喹啉衍生的酰胺，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。
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公开(公告)号：US08394828B2
公开(公告)日：2013-03-12
申请号：US12174017
申请日：2008-07-16
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D215/38 , C07D215/60 , C07D401/12 , C07D405/12 , C07D409/12 , C07D491/10
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to quinoline-derived amides that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的喹啉衍生的酰胺，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。
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7.发明申请公开(公告)号：US20100125140A1
公开(公告)日：2010-05-20
申请号：US12692128
申请日：2010-01-22
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： C07D217/02 , C07C275/28 , C07C335/18
CPC分类号： C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07C2602/10 , C07D217/02 , C07D217/08
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的β-氨基四氢萘衍生的脲，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。
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公开(公告)号：US07678812B2
公开(公告)日：2010-03-16
申请号：US11877220
申请日：2007-10-23
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： A61K31/47 , C07D211/06 , C07D217/22
CPC分类号： C07D213/40 , C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07C2601/02 , C07C2602/10 , C07D215/38 , C07D217/02 , C07D217/08 , C07D217/22 , C07D217/24 , C07D233/64 , C07D237/28 , C07D239/74 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/32 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的β-氨基四氢萘衍生的脲，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。
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9.发明授权Naphthol, quinoline and isoquinoline-derived urea modulators of vanilloid VR1 receptor 有权萘酚，喹啉和异喹啉衍生的凡士林VR1受体的尿素调节剂公开(公告)号：US07183411B2
公开(公告)日：2007-02-27
申请号：US10616579
申请日：2003-07-10
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： C07D217/22 , A61K31/47
CPC分类号： C07C275/28 , C07C275/30 , C07C275/32 , C07D213/40 , C07D215/38 , C07D217/02 , C07D217/22 , C07D217/24 , C07D235/14 , C07D307/52 , C07D333/20 , C07D333/58 , C07D401/12 , C07D409/04
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to naphthol, quinoline and isoquinoline-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地说，本发明涉及作为VR1的有效拮抗剂或激动剂的萘酚，喹啉和异喹啉衍生的脲，其可用于治疗和预防哺乳动物的炎性和其它疼痛状况。
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公开(公告)号：US08569505B2
公开(公告)日：2013-10-29
申请号：US12692128
申请日：2010-01-22
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： C07D217/02 , C07C275/28
CPC分类号： C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07C2602/10 , C07D217/02 , C07D217/08
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
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