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公开(公告)号:US08580260B2
公开(公告)日:2013-11-12
申请号:US12975667
申请日:2010-12-22
IPC分类号: A61K39/395 , A61P11/06 , C07K14/47 , C07K16/24 , C07K7/06
CPC分类号: C07K16/244 , A61K38/012 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C12N15/81 , C12P21/02 , Y10S514/853
摘要: The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译: 本发明涉及人抗IL-13结合分子,特别是抗体,以及在诊断或治疗IL-13相关疾病如哮喘,特应性皮炎,过敏性鼻炎, 纤维化,炎性肠病和霍奇金淋巴瘤。
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公开(公告)号:US09650438B2
公开(公告)日:2017-05-16
申请号:US14629587
申请日:2015-02-24
CPC分类号: C07K16/244 , A61K38/012 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C12N15/81 , C12P21/02 , Y10S514/853
摘要: The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
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公开(公告)号:US20170101467A9
公开(公告)日:2017-04-13
申请号:US14629587
申请日:2015-02-24
IPC分类号: C07K16/24
CPC分类号: C07K16/244 , A61K38/012 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C12N15/81 , C12P21/02 , Y10S514/853
摘要: The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
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公开(公告)号:US20150259411A1
公开(公告)日:2015-09-17
申请号:US14629587
申请日:2015-02-24
IPC分类号: C07K16/24
CPC分类号: C07K16/244 , A61K38/012 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C12N15/81 , C12P21/02 , Y10S514/853
摘要: The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译: 本发明涉及人抗IL-13结合分子,特别是抗体,以及在诊断或治疗IL-13相关疾病如哮喘,特应性皮炎,过敏性鼻炎, 纤维化,炎性肠病和霍奇金淋巴瘤。
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公开(公告)号:US08992916B2
公开(公告)日:2015-03-31
申请号:US14044314
申请日:2013-10-02
IPC分类号: A61K39/395 , C07K16/24 , A61K39/00
CPC分类号: C07K16/244 , A61K38/012 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C12N15/81 , C12P21/02 , Y10S514/853
摘要: The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译: 本发明涉及人抗IL-13结合分子,特别是抗体,以及在诊断或治疗IL-13相关疾病如哮喘,特应性皮炎,过敏性鼻炎, 纤维化,炎性肠病和霍奇金淋巴瘤。
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公开(公告)号:US07910708B2
公开(公告)日:2011-03-22
申请号:US12091020
申请日:2006-10-19
申请人: Emma Campbell , Sofia Parveen , Joe Buechler , Gunars Valkirs
发明人: Emma Campbell , Sofia Parveen , Joe Buechler , Gunars Valkirs
IPC分类号: C12P21/08 , C07K16/00 , A61K39/395 , A61K39/00
CPC分类号: C07K16/244 , A61K38/012 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C12N15/81 , C12P21/02 , Y10S514/853
摘要: The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译: 本发明涉及人抗IL-13结合分子,特别是抗体,以及在诊断或治疗IL-13相关疾病如哮喘,特应性皮炎,过敏性鼻炎, 纤维化,炎性肠病和霍奇金淋巴瘤。
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公开(公告)号:US20080267959A1
公开(公告)日:2008-10-30
申请号:US12091020
申请日:2006-10-19
申请人: Emma Campbell , Sofia Parveen , Joe Buechler , Gunars Valkirs
发明人: Emma Campbell , Sofia Parveen , Joe Buechler , Gunars Valkirs
IPC分类号: A61K39/395 , C07K16/24 , A61P11/06
CPC分类号: C07K16/244 , A61K38/012 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C12N15/81 , C12P21/02 , Y10S514/853
摘要: The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译: 本发明涉及人抗IL-13结合分子,特别是抗体,以及在诊断或治疗IL-13相关疾病如哮喘,特应性皮炎,过敏性鼻炎, 纤维化,炎性肠病和霍奇金淋巴瘤。
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公开(公告)号:US20110091458A1
公开(公告)日:2011-04-21
申请号:US12975667
申请日:2010-12-22
申请人: Emma CAMPBELL , Sofia Parveen , Joe Buechler , Gunars Valkirs
发明人: Emma CAMPBELL , Sofia Parveen , Joe Buechler , Gunars Valkirs
CPC分类号: C07K16/244 , A61K38/012 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C12N15/81 , C12P21/02 , Y10S514/853
摘要: The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译: 本发明涉及人抗IL-13结合分子,特别是抗体,以及在诊断或治疗IL-13相关疾病如哮喘,特应性皮炎,过敏性鼻炎, 纤维化,炎性肠病和霍奇金淋巴瘤。
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公开(公告)号:US07189515B2
公开(公告)日:2007-03-13
申请号:US10149737
申请日:2000-12-06
申请人: Joe Buechler , Gunars Valkirs , Jeff Gray , Nils Lonberg
发明人: Joe Buechler , Gunars Valkirs , Jeff Gray , Nils Lonberg
IPC分类号: G01N33/543
CPC分类号: C07K16/18 , C07K16/244 , C07K2317/21 , C07K2317/55 , G01N33/543 , Y02A50/55 , Y02A50/58 , Y10S435/962 , Y10S435/973 , Y10S436/809
摘要: The invention provides in vitro methods of detection using human antibodies. The methods are particularly useful for analyzing human samples containing HAMA or heterophilic antibodies. A human antibody can bind to an analyte in such samples without binding to HAMA or heterophilic antibodies present in the samples. The methods can be effected using a sandwich format among others.
摘要翻译: 本发明提供使用人抗体的体外检测方法。 该方法对于分析含有HAMA或异嗜性抗体的人类样品特别有用。 人抗体可以结合这样的样品中的分析物而不与样品中存在的HAMA或异嗜性抗体结合。 这些方法可以使用夹心形式等来实现。
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公开(公告)号:US20070111259A1
公开(公告)日:2007-05-17
申请号:US11521060
申请日:2006-09-13
申请人: Joe Buechler , Gunars Valkirs , Jeff Gray , Nils Lonberg
发明人: Joe Buechler , Gunars Valkirs , Jeff Gray , Nils Lonberg
CPC分类号: C07K16/005 , C07K16/244 , C07K16/26 , C07K16/44 , C07K2317/21 , C07K2317/55 , C07K2317/92
摘要: The invention uses the power of display selection methods to screen libraries of human immunoglobulin genes from nonhuman transgenic animals expressing human immunoglobulins. Such screening produces unlimited numbers of high affinity human antibodies to any target of interest.
摘要翻译: 本发明利用显示选择方法的功能来筛选表达人免疫球蛋白的非人转基因动物的人免疫球蛋白基因的文库。 这样的筛选产生无限数量的高亲和力的人抗体对任何感兴趣的目标。
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