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公开(公告)号：US07301036B2
公开(公告)日：2007-11-27
申请号：US10580183
申请日：2004-12-15
申请人： Emma R. Parmee , Ronald M. Kim , Elizabeth A. Rouse , Darby R. Schmidt , Christopher Joseph Sinz , Jiang Chang
发明人： Emma R. Parmee , Ronald M. Kim , Elizabeth A. Rouse , Darby R. Schmidt , Christopher Joseph Sinz , Jiang Chang
IPC分类号： C07D235/30
CPC分类号： C07D403/12 , C07D235/30 , C07D409/12
摘要： The present invention relates to cyclic guanidines, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
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2.发明授权公开(公告)号：US07968589B2
公开(公告)日：2011-06-28
申请号：US12702358
申请日：2010-02-09
申请人： John E. Stelmach , Emma R. Parmee , James R. Tata , Keith G. Rosauer , Ronald M. Kim , Amy R. Bittner , Jiang Chang , Christopher Joseph Sinz
发明人： John E. Stelmach , Emma R. Parmee , James R. Tata , Keith G. Rosauer , Ronald M. Kim , Amy R. Bittner , Jiang Chang , Christopher Joseph Sinz
IPC分类号： A61K31/404 , C07D209/10
CPC分类号： C07D209/18
摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
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公开(公告)号：US20110118282A1
公开(公告)日：2011-05-19
申请号：US12674795
申请日：2008-09-02
申请人： Amy R. Bittner , Christopher Joseph Sinz , Jiang Chang , Ronald M. Kim , J.W. Mirc , Emma R. Parmee , Qiang Tan
发明人： Amy R. Bittner , Christopher Joseph Sinz , Jiang Chang , Ronald M. Kim , J.W. Mirc , Emma R. Parmee , Qiang Tan
IPC分类号： A61K31/497 , C07D401/04 , C07D401/14 , C07D403/04 , C07D417/04 , C07D405/14 , C07D417/14 , C07D413/14 , C07D409/14 , A61K31/4439 , A61K31/444 , A61K31/427 , A61K31/506 , C12N9/88 , A61P9/00 , A61P9/10 , A61P9/12 , A61P15/10 , A61P11/06 , A61P13/12 , A61P3/10 , A61P1/16 , A61P9/08 , A61P7/10 , A61P3/06
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要： A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.
摘要翻译： 具有用于治疗或预防心血管疾病，内皮功能障碍，舒张功能障碍，动脉粥样硬化，高血压，心绞痛，血栓形成，再狭窄，心肌梗塞，中风，心功能不全，肺性高血压，勃起功能障碍，哮喘支气管炎，慢性肾脏的结构的化合物 功能不全，糖尿病或人类或动物患者肝脏肝硬化。
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4.发明授权Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use 有权胰高血糖素受体拮抗剂化合物，含有这些化合物的组合物和使用方法公开(公告)号：US07687534B2
公开(公告)日：2010-03-30
申请号：US11906374
申请日：2007-10-02
申请人： John E. Stelmach , Emma R. Parmee , James R. Tata , Keith G. Rosauer , Ronald M. Kim , Amy R. Bittner , Jiang Chang , Christopher Joseph Sinz
发明人： John E. Stelmach , Emma R. Parmee , James R. Tata , Keith G. Rosauer , Ronald M. Kim , Amy R. Bittner , Jiang Chang , Christopher Joseph Sinz
IPC分类号： A61K31/404 , C07D209/14
CPC分类号： C07D209/18
摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开了胰高血糖素受体拮抗剂化合物。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。
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5.发明申请GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 审中-公开GLUCAGON受体拮抗剂化合物，包含这些化合物的组合物和使用方法公开(公告)号：US20100004158A1
公开(公告)日：2010-01-07
申请号：US12443746
申请日：2007-09-27
申请人： John E. Stelmach , Emma R. Parmee , James R. Tata , Keith G. Rosauer , Ronald M. Kim , Amy R. Bittner , Jiang Chang , Christopher Joseph Sinz
发明人： John E. Stelmach , Emma R. Parmee , James R. Tata , Keith G. Rosauer , Ronald M. Kim , Amy R. Bittner , Jiang Chang , Christopher Joseph Sinz
IPC分类号： A61K38/28 , C07D209/04 , A61K31/404 , A61K31/397 , A61K31/4985 , A61K31/426 , A61P3/10 , A61P3/04
CPC分类号： C07D209/18
摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included. (I)
摘要翻译： 公开了胰高血糖素受体拮抗剂化合物。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。 （一世）
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公开(公告)号：US20090209556A1
公开(公告)日：2009-08-20
申请号：US12430420
申请日：2009-04-27
申请人： Amy R. Bittner , Christopher Joseph Sinz , Jiang Chang , Ronald M. Kim , J. W. Mirc , Emma R. Parmee , Qiang Tan
发明人： Amy R. Bittner , Christopher Joseph Sinz , Jiang Chang , Ronald M. Kim , J. W. Mirc , Emma R. Parmee , Qiang Tan
IPC分类号： A61K31/497 , A61K31/4545 , A61K31/4439 , C07D403/04 , C07D401/14 , C07D401/04 , A61P9/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要： A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.
摘要翻译： 具有用于治疗或预防心血管疾病，内皮功能障碍，舒张功能障碍，动脉粥样硬化，高血压，心绞痛，血栓形成，再狭窄，心肌梗塞，中风，心功能不全，肺性高血压，勃起功能障碍，哮喘支气管炎，慢性肾脏的结构的化合物 功能不全，糖尿病或人类或动物患者肝脏肝硬化。
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公开(公告)号：US08455638B2
公开(公告)日：2013-06-04
申请号：US12674795
申请日：2008-09-02
申请人： Amy R. Bittner , Ronald M. Kim , John W. Mirc , Emma R. Parmee , Christopher Joseph Sinz , Qiang Tan
发明人： Amy R. Bittner , Ronald M. Kim , John W. Mirc , Emma R. Parmee , Christopher Joseph Sinz , Qiang Tan
IPC分类号： C07D345/00 , C07D517/00 , C07D413/00 , C07D401/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要： A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.
摘要翻译： 具有用于治疗或预防心血管疾病，内皮功能障碍，舒张功能障碍，动脉粥样硬化，高血压，心绞痛，血栓形成，再狭窄，心肌梗塞，中风，心功能不全，肺性高血压，勃起功能障碍，哮喘支气管炎，慢性肾脏的结构的化合物 功能不全，糖尿病或人类或动物患者肝脏肝硬化。
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公开(公告)号：US08507512B2
公开(公告)日：2013-08-13
申请号：US12711854
申请日：2010-02-24
IPC分类号： A01N43/54 , A01N43/40 , A61K31/505 , A61K31/44 , C07D239/02 , C07D401/00
CPC分类号： C07D401/04 , C07D401/14
摘要： This inventions relates to compounds having the structure Formula I and pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
摘要翻译： 本发明涉及具有结构式I的化合物及其可药用盐，它们是可溶性鸟苷酸环化酶活化剂。 该化合物可用于治疗或预防心血管疾病，内皮功能障碍，舒张功能障碍，动脉粥样硬化，高血压，肺动脉高压，心绞痛，血栓形成，再狭窄，心肌梗死，中风，心功能不全，肺性高血压，勃起功能障碍，支气管哮喘，慢性 肾功能不全，糖尿病或肝硬化。
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公开(公告)号：US20100216764A1
公开(公告)日：2010-08-26
申请号：US12711854
申请日：2010-02-24
IPC分类号： A61K31/397 , C07D401/14 , A61K31/4545 , A61K31/4353 , C07D487/08 , A61P9/00 , A61P11/06 , A61P3/10
CPC分类号： C07D401/04 , C07D401/14
摘要： This inventions relates to compounds having the structure Formula I and pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
摘要翻译： 本发明涉及具有结构式I的化合物及其可药用盐，它们是可溶性鸟苷酸环化酶活化剂。 该化合物可用于治疗或预防心血管疾病，内皮功能障碍，舒张功能障碍，动脉粥样硬化，高血压，肺动脉高压，心绞痛，血栓形成，再狭窄，心肌梗死，中风，心功能不全，肺性高血压，勃起功能障碍，支气管哮喘，慢性 肾功能不全，糖尿病或肝硬化。
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10.发明授权公开(公告)号：US07598398B2
公开(公告)日：2009-10-06
申请号：US11580714
申请日：2006-10-13
IPC分类号： C07D209/12 , A61K31/33
CPC分类号： C07D209/08 , C07D209/18 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D405/06 , C07D417/04 , C07D417/06
摘要： The present invention relates to substituted indoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus and related conditions.
摘要翻译： 本发明涉及取代的吲哚，含有这些化合物的组合物和治疗方法该化合物是胰高血糖素受体拮抗剂，因此可用于治疗，预防或延缓2型糖尿病的发病和相关病症。
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