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    2-{2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole and methods for inducing differentiation of myoblasts or muscle fibers into neuron cells
    3.
    发明授权
    2-{2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole and methods for inducing differentiation of myoblasts or muscle fibers into neuron cells 有权
    2- {2- [5-（3-氯苯基）]呋喃基} -4,5-双（4-甲氧基苯基）咪唑和诱导成肌细胞或肌纤维分化成神经元细胞的方法

    公开(公告)号：US07888118B2

    公开(公告)日：2011-02-15

    申请号：US12749922

    申请日：2010-03-30

    申请人： In-Jae Shin ,  Myung-Ryul Lee ,  Darren Williams

    发明人： In-Jae Shin ,  Myung-Ryul Lee ,  Darren Williams

    IPC分类号： C12N5/00

    CPC分类号： C07D405/04 ,  C07D233/64

    摘要： The present invention relates to 4,5-bis(4-methoxyphenyl)imidazole compound inducing differentiation of myoblasts or muscle fibers into neuron cells, a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation. More specifically, it relates to 2-{2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole that induces differentiation of myoblasts or muscle fibers into neuron cells, all pharmaceutically acceptable isomers, salts, and a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation.

    摘要翻译： 本发明涉及诱导成肌细胞或肌纤维分化为神经元细胞的4,5-双（4-甲氧基苯基）咪唑化合物，包含所述化合物的药物组合物，诱导神经元细胞分化的方法和鉴定另外的化合物的筛选方法 可用于诱导神经细胞分化。 更具体地说，它涉及诱导成肌细胞或肌纤维分化成神经细胞的2- {2- [5-（3-氯苯基）]呋喃基} -4,5-双（4-甲氧基苯基）咪唑，所有药学上可接受的异构体 盐，以及包含所述化合物的药物组合物，诱导神经元细胞分化的方法以及鉴定用于诱导神经元细胞分化的其它化合物的筛选方法。

    Refrigerator having basket lift apparatus
    4.
    发明授权
    Refrigerator having basket lift apparatus 有权
    冰箱具有提篮设备

    公开(公告)号：US07810891B2

    公开(公告)日：2010-10-12

    申请号：US11178451

    申请日：2005-07-12

    申请人： Myung-Ryul Lee ,  Seong-Jae Kim ,  Seung-Hwan Oh

    发明人： Myung-Ryul Lee ,  Seong-Jae Kim ,  Seung-Hwan Oh

    IPC分类号： A47B96/04

    CPC分类号： F25D25/022 ,  A47B51/00 ,  A47B67/04 ,  A47B2210/17 ,  F25D23/021 ,  F25D25/005 ,  F25D25/025 ,  F25D25/04

    摘要： A refrigerator includes a main body having cooling chambers for keeping food items therein, a base frame disposed to be movable in outward and inward directions in a lower cooling chamber disposed at a lower portion of the main body, and having a basket door at its front side, a lift frame disposed on the base frame, on which the basket is put, a fluid pressure cylinder mounted at the base frame and connected to the lift frame to lift the lift frame, and an fluid compressor connected to the fluid pressure cylinder by an fluid supply pipe and supplying compressed fluid to the fluid pressure cylinder. Accordingly, as the basket is lifted when being drawn out, a user can take out food items kept in the basket without bending his/her back, which enhances user's convenience.

    摘要翻译： 冰箱包括具有用于保持食品的冷却室的主体，设置成能够在设置在主体的下部的下部冷却室中沿外部和内侧方向移动的基座框架，并且在其前部具有筐门 设置在其上放置篮子的基架上的提升框架，安装在基座框架处并连接到升降机架以提升升降架的流体压力缸，以及通过以下方式连接到流体压力缸的流体压缩机 流体供应管道，并将压缩流体供应到流体压力缸。 因此，当抽出时，使用者可以取出保存在篮子中的食品，而不会使其背部弯曲，这增强了使用者的便利性。

    4,5-bis(4-methoxyphenyl)imidizole compound inducing differentiation of myoblasts or muscle fibers and pharmaceutical compositions including said compound
    5.
    发明授权
    4,5-bis(4-methoxyphenyl)imidizole compound inducing differentiation of myoblasts or muscle fibers and pharmaceutical compositions including said compound 有权
    诱导成肌细胞或肌肉纤维分化的4,5-双（4-甲氧基苯基）亚胺唑酮化合物和包含所述化合物的药物组合物

    公开(公告)号：US07718685B2

    公开(公告)日：2010-05-18

    申请号：US11337145

    申请日：2006-01-20

    申请人： In-Jae Shin ,  Myung-Ryul Lee ,  Darren Williams

    发明人： In-Jae Shin ,  Myung-Ryul Lee ,  Darren Williams

    IPC分类号： A01N43/50

    CPC分类号： C07D405/04 ,  C07D233/64

    摘要： The present invention relates to 4,5-bis(4-methoxyphenyl)imidazole compound inducing differentiation of myoblasts or muscle fibers into neuron cells and a pharmaceutical composition including said compound. More specifically, it relates to 2-(2-fluorenyl)-4,5-bis(4-methoxyphenyl)imidazole that induces differentiation of myoblasts or muscle fibers, all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug thereof, and a pharmaceutical composition including said compound.

    摘要翻译： 本发明涉及诱导成肌细胞或肌纤维分化为神经元细胞的4,5-双（4-甲氧基苯基）咪唑化合物和包含所述化合物的药物组合物。 更具体地说，本发明涉及诱导成肌细胞或肌纤维分化的2-（2-芴基）-4,5-双（4-甲氧基苯基）咪唑，其所有药学上可接受的异构体，盐，水合物，溶剂合物和前药，以及 包含所述化合物的药物组合物。

    Bottom drawer type refrigerator having basket lift device
    6.
    发明申请
    Bottom drawer type refrigerator having basket lift device 审中-公开
    底部抽屉式冰箱具有篮提升装置

    公开(公告)号：US20060022564A1

    公开(公告)日：2006-02-02

    申请号：US11101584

    申请日：2005-04-08

    申请人： Seung-Hwan Oh ,  Kyung-Han Jeong ,  Sung-Hoon Chung ,  Myung-Ryul Lee

    发明人： Seung-Hwan Oh ,  Kyung-Han Jeong ,  Sung-Hoon Chung ,  Myung-Ryul Lee

    IPC分类号： A47B88/00

    CPC分类号： F25D25/025 ,  A47B51/00 ,  A47B67/04 ,  A47B2210/17 ,  F25D23/021 ,  F25D25/005 ,  F25D25/04

    摘要： A refrigerator includes a main body having at least a lower cooling chamber disposed at a lower portion of the main body, a base frame disposed to be movable in inward/outward directions at the lower cooling chamber and having a drawer door at a front side thereof, a lift frame disposed at an upper surface of the base frame, on which a basket is placed, a gas spring mounted vertically at an upper surface of the base frame and connected with the lift frame for lifting the lift frame, and lift rails at a rear side of the drawer door and guiding the lift frame to be moved up and down.

    摘要翻译： 一种冰箱，包括主体，所述主体至少具有设置在所述主体的下部的下部冷却室，基部框架设置成能够在所述下部冷却室的内部/外侧方向上移动，并且在其前侧具有抽屉门 设置在其上放置篮子的基座框架的上表面的提升框架，垂直安装在底座框架的上表面处并与升降架相连的气弹簧，用于提升升降机架， 抽屉门的后侧并引导升降架上下移动。

    4,5-BIS(4-METHOXYPHENYL)IMIDAZOLE COMPOUND INDUCING DIFFERENTIATION OF MYOBLASTS OR MUSCLE FIBERS INTO NEURON CELLS, A PHARMACEUTICAL COMPOSITION INCLUDING SAID COMPOUND, A METHOD OF INDUCING NEURON CELLS DIFFERENTIATION AND A SCREENING METHOD FOR IDENTIFYING ADDITIONAL COMPOUND USEFUL FOR INDUCING NEURON CELLS DIFFERENTIATION
    7.
    发明申请
    4,5-BIS(4-METHOXYPHENYL)IMIDAZOLE COMPOUND INDUCING DIFFERENTIATION OF MYOBLASTS OR MUSCLE FIBERS INTO NEURON CELLS, A PHARMACEUTICAL COMPOSITION INCLUDING SAID COMPOUND, A METHOD OF INDUCING NEURON CELLS DIFFERENTIATION AND A SCREENING METHOD FOR IDENTIFYING ADDITIONAL COMPOUND USEFUL FOR INDUCING NEURON CELLS DIFFERENTIATION 有权
    4-BIS（4-甲氧基苯基）咪唑化合物诱导将神经细胞分解成神经细胞或肌肉纤维，包括化合物的药物组合物，诱导神经细胞分化的方法和用于鉴定用于诱导神经细胞的附加化合物的筛选方法 差异化

    公开(公告)号：US20100184097A1

    公开(公告)日：2010-07-22

    申请号：US12749922

    申请日：2010-03-30

    申请人： In-Jae Shin ,  Myung-Ryul Lee ,  Darren Williams

    发明人： In-Jae Shin ,  Myung-Ryul Lee ,  Darren Williams

    IPC分类号： G01N33/567 ,  C07D233/54 ,  C12N5/071

    CPC分类号： C07D405/04 ,  C07D233/64

    摘要： The present invention relates to 4,5-bis(4-methoxyphenyl)imidazole compound inducing differentiation of myoblasts or muscle fibers into neuron cells, a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation. More specifically, it relates to 2-{2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole that induces differentiation of myoblasts or muscle fibers into neuron cells, all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug thereof, and a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation.

    摘要翻译： 本发明涉及诱导成肌细胞或肌纤维分化为神经元细胞的4,5-双（4-甲氧基苯基）咪唑化合物，包含所述化合物的药物组合物，诱导神经元细胞分化的方法和鉴定另外的化合物的筛选方法 可用于诱导神经细胞分化。 更具体地说，它涉及诱导成肌细胞或肌纤维分化成神经细胞的2- {2- [5-（3-氯苯基）]呋喃基} -4,5-双（4-甲氧基苯基）咪唑，所有药学上可接受的异构体 ，盐，水合物，溶剂化物和前药，以及包含所述化合物的药物组合物，诱导神经元细胞分化的方法和用于鉴定用于诱导神经元细胞分化的另外的化合物的筛选方法。

    Compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation
    8.
    发明申请
    Compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation 有权
    诱导成肌细胞或肌纤维分化成神经元细胞的化合物，包括所述化合物的药物组合物，诱导神经元分化的方法和用于鉴定用于诱导神经元分化的其它化合物的筛选方法

    公开(公告)号：US20070123576A1

    公开(公告)日：2007-05-31

    申请号：US11337145

    申请日：2006-01-20

    申请人： In-Jae Shin ,  Myung-Ryul Lee ,  Darren Williams

    发明人： In-Jae Shin ,  Myung-Ryul Lee ,  Darren Williams

    IPC分类号： A61K31/4178 ,  A61K31/4164 ,  C07D405/04 ,  C07D233/58

    CPC分类号： C07D405/04 ,  C07D233/64

    摘要： The present invention relates to compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation. More specifically, it relates to compounds that induce neuron differentiation from myoblasts or muscle fibers, all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrugs thereof, the method of inducing differentiation of myoblasts or muscle fibers into neuron cells by treating myoblasts and muscle fibers with a compound of the present invention, whereby the myoblasts and muscle fibers differentiate into neuron cells, and the screening method for identifying additional compounds useful for inducing neuron differentiation, wherein myoblasts and muscle fibers are incubated with a compound of the present invention and detected.

    摘要翻译： 本发明涉及诱导成肌细胞或肌纤维分化为神经元细胞的化合物，包括所述化合物的药物组合物，诱导神经元分化的方法和用于鉴定用于诱导神经元分化的其它化合物的筛选方法。 更具体地说，本发明涉及从成肌细胞或肌肉纤维诱导神经元分化的化合物，其所有药学上可接受的异构体，盐，水合物，溶剂合物和前药，通过治疗成肌细胞和肌纤维诱导成肌细胞或肌纤维分化成神经细胞的方法 与本发明的化合物，由此成肌细胞和肌肉纤维分化成神经元细胞，以及用于鉴定用于诱导神经元分化的其它化合物的筛选方法，其中成肌细胞和肌肉纤维与本发明的化合物一起孵育并检测。

    Refrigerator having basket lift apparatus
    9.
    发明申请
    Refrigerator having basket lift apparatus 有权
    冰箱具有提篮设备

    公开(公告)号：US20060103273A1

    公开(公告)日：2006-05-18

    申请号：US11178451

    申请日：2005-07-12

    申请人： Myung-Ryul Lee ,  Seong-Jae Kim ,  Seung-Hwan Oh

    发明人： Myung-Ryul Lee ,  Seong-Jae Kim ,  Seung-Hwan Oh

    IPC分类号： A47B77/08

    CPC分类号： F25D25/022 ,  A47B51/00 ,  A47B67/04 ,  A47B2210/17 ,  F25D23/021 ,  F25D25/005 ,  F25D25/025 ,  F25D25/04

    摘要： A refrigerator includes a main body having cooling chambers for keeping food items therein, a base frame disposed to be movable in outward and inward directions in a lower cooling chamber disposed at a lower portion of the main body, and having a basket door at its front side, a lift frame disposed on the base frame, on which the basket is put, a fluid pressure cylinder mounted at the base frame and connected to the lift frame to lift the lift frame, and an fluid compressor connected to the fluid pressure cylinder by an fluid supply pipe and supplying compressed fluid to the fluid pressure cylinder. Accordingly, as the basket is lifted when being drawn out, a user can take out food items kept in the basket without bending his/her back, which enhances user's convenience.

    摘要翻译： 冰箱包括具有用于保持食品的冷却室的主体，设置成能够在设置在主体的下部的下部冷却室中沿外部和内侧方向移动的基座框架，并且在其前部具有筐门 设置在其上放置篮子的基架上的提升框架，安装在基座框架处并连接到升降机架以提升升降架的流体压力缸，以及通过以下方式连接到流体压力缸的流体压缩机 流体供应管道，并将压缩流体供应到流体压力缸。 因此，当抽出时，使用者可以取出保存在篮子中的食品，而不会使其背部弯曲，这增强了使用者的便利性。