公开(公告)号：US06362484B1

公开(公告)日：2002-03-26

申请号：US09247627

申请日：1999-02-10

申请人： Eric Beyne ,  Amos Breskin ,  Rachel Chechik ,  Stefaan Tavernier ,  Walter Van Doninck

发明人： Eric Beyne ,  Amos Breskin ,  Rachel Chechik ,  Stefaan Tavernier ,  Walter Van Doninck

IPC分类号： G01J528

CPC分类号： G01T1/2935 ,  H01J47/02

摘要： The present invention may provide a particle or radiation detector or imager which may be used for accurate recording of medical (2-D) X-ray images. The imager includes at least one detector panel. The detector panel includes a microgap detector with an array of pixel electrodes of a novel form. Each pixel electrode is insulated from a planar cathode by means of an insulating layer. Each pixel electrode is connected to an underlying contact by means of a via hole in the insulating layer. The insulating layer is preferably conformal with the electrodes. The underlying contact is connected to an electronic measuring element which preferably lies underneath the electrode and is about the same size as the electrode. The measuring element may be a storage device, a digital counter or similar. A switching transistor is connected to the measuring device. The switching transistor may be a thin film transistor. Alternatively, both measuring element and transistor may be formed in a single crystal semiconductor, e.g. a VLSI, and a complete imager formed from several detector panels in an array. The drift electrode of the microgap detector preferably includes a photocathode. The photocathode may be directly evaporated onto a phosphor.

摘要翻译： 本发明可以提供可用于医疗（2-D）X射线图像的精确记录的粒子或辐射检测器或成像器。 成像器包括至少一个检测器面板。 检测器面板包括具有新颖形式的像素电极阵列的微隙检测器。 每个像素电极通过绝缘层与平面阴极绝缘。 每个像素电极通过绝缘层中的通孔连接到下面的触点。 绝缘层优选与电极保持一致。底层触点连接到电子测量元件，电子测量元件优选地位于电极下方并且与电极大致相同的尺寸。 测量元件可以是存储装置，数字计数器等。 开关晶体管连接到测量装置。 开关晶体管可以是薄膜晶体管。 或者，测量元件和晶体管都可以形成在单晶半导体中，例如， VLSI，以及由阵列中的多个检测器面板形成的完整成像器。微间隙检测器的漂移电极优选包括光电阴极。 光电阴极可以直接蒸发到磷光体上。

公开(公告)号：US6121622A

公开(公告)日：2000-09-19

申请号：US21221

申请日：1998-02-10

申请人： Eric Beyne ,  Amos Breskin ,  Rachel Chechik ,  Stefaan Tavernier ,  Walter Van Doninck

发明人： Eric Beyne ,  Amos Breskin ,  Rachel Chechik ,  Stefaan Tavernier ,  Walter Van Doninck

IPC分类号： G01T1/29 ,  H01J47/02 ,  G01J5/28 ,  H01J40/06

CPC分类号： G01T1/2935 ,  H01J47/02

摘要： The present invention may provide a particle detector or imager which may be used for accurate recording of medical (2-D) X-ray images. The imager includes at least one detector panel. The detector panel includes a microgap detector with an array of pixel electrodes of a novel form. Each pixel electrode is insulated from a planar cathode by means of an insulating layer. Each pixel electrode is connected to an underlying contact by means of a via hole in the insulating layer. The insulating layer is preferable conformal with the electrodes. The underlying contact is connected to an electronic measuring element which preferably lies underneath the electrode and is about the same size as the electrode. The measuring element may be a storage device, a digital counter or similar. A switching transistor is connected to the measuring device. The switching transistor may be a thin film transistor. Alternatively, both measuring element and transistor may be formed in a single crystal semiconductor, e.g. a VLSI, and a complete imager formed from several detector panels in an array. The drift electrode of the microgap detector preferably includes a photocathode. The photocathode may be directly evaporated onto a phosphor.

摘要翻译： 本发明可以提供可用于医疗（2-D）X射线图像的精确记录的粒子检测器或成像器。 成像器包括至少一个检测器面板。 检测器面板包括具有新颖形式的像素电极阵列的微隙检测器。 每个像素电极通过绝缘层与平面阴极绝缘。 每个像素电极通过绝缘层中的通孔连接到下面的触点。 绝缘层优选与电极保持一致。 底层触点连接到电子测量元件，电子测量元件优选地位于电极下方并且与电极大约相同的尺寸。 测量元件可以是存储装置，数字计数器等。 开关晶体管连接到测量装置。 开关晶体管可以是薄膜晶体管。 或者，测量元件和晶体管都可以形成在单晶半导体中，例如， VLSI，以及由阵列中的几个检测器面板形成的完整成像器。 微隙检测器的漂移电极优选包括光电阴极。 光电阴极可以直接蒸发到磷光体上。

公开(公告)号：US06694171B1

公开(公告)日：2004-02-17

申请号：US09445977

申请日：2000-03-06

申请人： Amos Breskin ,  Rachel Chechik ,  Zvi Paltiel ,  Bilha Schechter ,  Abraham Warshawsky ,  Abraham Shanzer ,  Michal Neeman

发明人： Amos Breskin ,  Rachel Chechik ,  Zvi Paltiel ,  Bilha Schechter ,  Abraham Warshawsky ,  Abraham Shanzer ,  Michal Neeman

IPC分类号： A61B500

CPC分类号： A61K49/04

摘要： A delivery system and method for targeting a contrast agent to tissues and organs for improved diagnosis of tumors and for prognosis and follow-up of cancer therapy by X-ray imaging. The delivery system includes a conjugate or complex of a macromolecular carrier and a contrast agent selected from the group consisting of: (a) a compound having a heavy element with an atomic number in the range of 75 to 92, and (b) a compound having an element with a property of an abrupt change in its X-ray attenuation coefficient within the energy range used for radiography, said macromolecular carrier of said conjugate or complex being optionally linked to a specific tissue marker molecule.

摘要翻译： 用于将造影剂靶向组织和器官的递送系统和方法，用于改善肿瘤的诊断以及通过X射线成像进行癌症治疗的预后和随访。 递送系统包括大分子载体和造影剂的共轭物或复合物，其选自：（a）原子序数在75至92范围内的重元素的化合物，和（b）化合物 具有在用于放射照相的能量范围内其X射线衰减系数突然变化的性质的元件，所述缀合物或复合物的所述大分子载体任选地连接到特定的组织标记分子。

公开(公告)号：US06531816B1

公开(公告)日：2003-03-11

申请号：US09423278

申请日：1999-11-04

申请人： Amos Breskin ,  Rachel Chechik ,  Alexei Buzulutskov

发明人： Amos Breskin ,  Rachel Chechik ,  Alexei Buzulutskov

IPC分类号： H01J4006

CPC分类号： H01J1/34 ,  H01J2201/3426

摘要： This invention discloses a thin-film-coated photocathode, including a photocathode formed of first material consisting of potassium cesiuin antimonide and a thin-film coating of a second material consisting of cesium bromide (CsBr).

摘要翻译： 本发明公开了一种薄膜涂覆的光电阴极，其包括由铯氯化镉组成的第一材料和由溴化铯（CsBr）组成的第二材料的薄膜涂层形成的光电阴极。

公开(公告)号：US4999500A

公开(公告)日：1991-03-12

申请号：US429291

申请日：1989-10-31

申请人： Amos Breskin ,  Rachel Chechik

发明人： Amos Breskin ,  Rachel Chechik

IPC分类号： G01T1/29

CPC分类号： G01T1/2935

摘要： Apparatus for radiographic imaging including a multistage avalanche chamber receiving radiation from a multiplicity of radiation point sources on a sample and providing a multiple photon output indicative of the path of the emitted radiation through the avalanche chamber, image intensification apparatus receiving the photon output of the avalanche chamber, a camera receiving an output from the image intensification apparatus; image processing apparatus for receiving the camera output and carrying out a vector analysis on the information contained in the camera output in order to determine the location of the radiation emitting point source on the sample.

公开(公告)号：US09052319B2

公开(公告)日：2015-06-09

申请号：US13512929

申请日：2009-12-10

申请人： Avi Simon ,  Meir Weksler ,  Amos Breskin ,  Rachel Chechik ,  Marco Cortesi

发明人： Avi Simon ,  Meir Weksler ,  Amos Breskin ,  Rachel Chechik ,  Marco Cortesi

IPC分类号： G01N33/574

CPC分类号： G01N33/57434

摘要： A method of analyzing a plurality of biopsy cores extracted from a plurality of respective biopsy locations in a prostate is disclosed. The method comprises: measuring a level of a chemical element in each of the biopsy cores, and generating a chemical element map of at least a portion of the prostate based on the levels and the respective biopsy locations. In some embodiments, the method determines at least one additional biopsy location for a future biopsy in the prostate.

摘要翻译： 公开了一种分析从前列腺中的多个相应活检位置提取的多个活检核心的方法。 该方法包括：测量每个活检核心中的化学元素的水平，以及基于水平和相应的活检位置产生前列腺的至少一部分的化学元素图。 在一些实施方案中，该方法确定至少一个额外的活组织检查位置用于未来前列腺活检。

公开(公告)号：US20120282648A1

公开(公告)日：2012-11-08

申请号：US13512929

申请日：2009-12-10

申请人： Avi Simon ,  Meir Weksler ,  Amos Breskin ,  Rachel Chechik ,  Marco Cortesi

发明人： Avi Simon ,  Meir Weksler ,  Amos Breskin ,  Rachel Chechik ,  Marco Cortesi

IPC分类号： G01N21/64 ,  C12M1/34

CPC分类号： G01N33/57434

摘要： A method of analyzing a plurality of biopsy cores extracted from a plurality of respective biopsy locations in a prostate is disclosed. The method comprises: measuring a level of a chemical element in each of the biopsy cores, and generating a chemical element map of at least a portion of the prostate based on the levels and the respective biopsy locations. In some embodiments, the method determines at least one additional biopsy location for a future biopsy in the prostate.

摘要翻译： 公开了一种分析从前列腺中的多个相应活检位置提取的多个活检核心的方法。 该方法包括：测量每个活检核心中的化学元素的水平，以及基于水平和相应的活检位置产生前列腺的至少一部分的化学元素图。 在一些实施方案中，该方法确定至少一个额外的活组织检查位置用于未来前列腺活检。

公开(公告)号：US20100312072A1

公开(公告)日：2010-12-09

申请号：US12811381

申请日：2009-01-01

申请人： Amos Breskin ,  Rachel Chechik ,  Sana Shilstein ,  Marco Cortesi

发明人： Amos Breskin ,  Rachel Chechik ,  Sana Shilstein ,  Marco Cortesi

IPC分类号： A61B5/00 ,  C40B30/02 ,  C40B60/12

CPC分类号： A61B6/50 ,  A61B6/4057 ,  A61B6/4092 ,  A61B6/425 ,  A61B6/4488 ,  A61B6/485 ,  G06T7/0012 ,  G06T2207/10121 ,  G06T2207/30081

摘要： A method of estimating a grade of a prostate cancer from zinc data associated with the prostate, the zinc data being arranged gridwise in a plurality of picture-elements representing a zinc map of the prostate. The method comprises, clustering the zinc map according to zinc levels associated with the picture-elements, and estimating a cancer grade of at least one tissue region, based, at least in part, on zinc levels associated with a cluster of picture-elements representing the tissue region.

摘要翻译： 从与前列腺相关的锌数据估计前列腺癌的分级的方法，锌数据以表示前列腺锌图的多个图像元素格格排列。 该方法包括：至少部分地基于与图像元素簇相关联的锌水平，根据与图像元素相关联的锌水平对锌图进行聚类，以及估计至少一个组织区域的癌症等级 组织区域。

公开(公告)号：US5194738A

公开(公告)日：1993-03-16

申请号：US725618

申请日：1991-07-03

申请人： Amos Breskin ,  Rachel Chechik ,  Ehud Dafni

发明人： Amos Breskin ,  Rachel Chechik ,  Ehud Dafni

IPC分类号： G01N27/447 ,  G01T1/28 ,  H01J47/02

CPC分类号： G01T1/28 ,  G01N27/44717 ,  H01J47/02

摘要： Apparatus for digital imaging including at least one electron multiplier arranged to receive beta radiation from a sample, apparatus for collimating the beta radiation without totally blocking all radiation from any location within a given region of interest on the sample, and readout electrodes operative in response to electrons from the electron multiplier to provide a first output indication of the incidence and location of beta radiation from the sample.

公开(公告)号：US07081619B2

公开(公告)日：2006-07-25

申请号：US10894873

申请日：2004-07-20

申请人： Vladimir Bashkirov ,  Reinhard W. Schulte ,  Sergei Shchemelinin ,  Amos Breskin ,  Rachel Chechik ,  Guy Garty ,  Jamie Milligan

发明人： Vladimir Bashkirov ,  Reinhard W. Schulte ,  Sergei Shchemelinin ,  Amos Breskin ,  Rachel Chechik ,  Guy Garty ,  Jamie Milligan

IPC分类号： H01J49/40

CPC分类号： H01J49/40 ,  G01N27/64

摘要： A nanodosimeter device (15) for detecting positive ions induced in a sensitive gas volume by a radiation field of primary particle, comprising an ionization chamber (10) for holding the sensitive gas volume to be irradiated by the radiation field of primary particles; an ion counter system connected to the ionization chamber (10) for detecting the positive ions which pass through the aperture opening and arrive at the ion counter (12) at an arrival time; a particle tracking system for position-sensitive detection of the primary particles passing through the sensitive gas volume; and a data acquisition system capable of coordinating the readout of all data signals and of performing data analysis correlating the arrival time of the positive ions detected by the ion counter system relative to the position sensitive data of primary particles detected by the particle tracking system. The invention further includes the use of the nanodosimeter for method of calibrating radiation exposure with damage to a nucleic acid within a sample. A volume of tissue-equivalent gas is radiated with a radiation field to induce positive ions. The resulting positive ions are measured and compared with a determination of presence or extent of damage resulting from irradiating a nucleic acid sample with an equivalent dose of radiation.

摘要翻译： 1.一种用于通过一次粒子的辐射场检测在敏感气体体积中诱导的正离子的纳米量测装置（15），包括用于保持由一次粒子的辐射场照射的敏感气体体积的电离室（10） 连接到所述电离室（10）的离子计数器系统，用于检测通过所述孔口的正离子，并在到达时到达所述离子计数器（12）; 用于通过敏感气体体积的一次颗粒的位置敏感检测的粒子跟踪系统; 以及数据采集系统，其能够协调所有数据信号的读出和执行数据分析，使由离子计数器系统检测到的正离子的到达时间相对于由粒子跟踪系统检测到的初级粒子的位置敏感数据相关。 本发明还包括使用纳米测量仪来校准辐射暴露的方法，其损害样品内的核酸。 用辐射场辐射体积的组织当量气体以诱导正离子。 测量所得到的正离子并与用等效剂量的辐射照射核酸样品所产生的损伤的存在或程度进行比较。