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公开(公告)号：US08029774B2
公开(公告)日：2011-10-04
申请号：US11479627
申请日：2006-07-01
IPC分类号： A61K31/74 , A61K38/39 , A61K38/00 , A61K47/48 , A61F2/00 , A61P17/02 , C08G63/48 , C08G63/91 , C08L89/00
CPC分类号： C08G18/3821 , A61K31/28 , A61K38/39 , A61K45/06 , A61K47/59 , A61K47/60 , A61L26/0019 , A61L26/0066 , A61L26/008 , A61L2300/104 , A61L2300/214 , A61L2300/252 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/418 , C08G18/10 , C08G18/3206 , C08G18/3218 , C08G18/4833 , C08G18/771 , C08G18/8022 , C08G2230/00
摘要： A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing molecule retains the ability to undergo free radical polymerization after attachment of the bioactive agent thereto. The first polymerizing molecule is preferably biocompatible. The polymerizing molecule can, for example. be dihydroxyphenyl-L-alanine (DOPA) or tyrosine. The composition can also include a second component synthesized by reacting at least one core molecule having a plurality of reactive hydrogen groups with at least one multi-isocyanate functional molecule to create a conjugate including terminal isocyanate groups. The conjugate molecule is reacted with a second polymerizing molecule that is adapted to undergo a free radical polymerization. The second polymerizing molecule includes a reactive hydrogen to react with the isocyanate groups of the conjugate. The second polymerizing molecule retains the ability to undergo the free radical polymerization after reaction with the conjugate. In several embodiments, the first polymerizing molecule and the second polymerizing molecule are the same and dihydroxyphenyl-L-alanine (DOPA) or tyrosine.
摘要翻译： 组合物包含共价连接到适于进行自由基聚合的第一聚合分子的至少一种生物活性剂。 第一聚合分子保留在生物活性剂附着后进行自由基聚合的能力。 第一聚合分子优选是生物相容的。 聚合分子可以，例如。 是二羟基苯基-L-丙氨酸（DOPA）或酪氨酸。 组合物还可以包括通过使具有多个反应性氢基团的至少一个核心分子与至少一个多异氰酸酯官能分子反应以产生包含末端异氰酸酯基团的缀合物而合成的第二组分。 共轭分子与适于进行自由基聚合的第二聚合分子反应。 第二聚合分子包括与偶联物的异氰酸酯基反应的反应性氢。 第二聚合分子保留在与缀合物反应后进行自由基聚合的能力。 在几个实施方案中，第一聚合分子和第二聚合分子是相同的，并且是二羟基苯基-L-丙氨酸（DOPA）或酪氨酸。
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公开(公告)号：US20070014755A1
公开(公告)日：2007-01-18
申请号：US11479627
申请日：2006-07-01
申请人： Eric Beckman , Stephen Badylak , Alan Wells , Jianying Zhang , Donald Freytes
发明人： Eric Beckman , Stephen Badylak , Alan Wells , Jianying Zhang , Donald Freytes
CPC分类号： C08G18/3821 , A61K31/28 , A61K38/39 , A61K45/06 , A61K47/59 , A61K47/60 , A61L26/0019 , A61L26/0066 , A61L26/008 , A61L2300/104 , A61L2300/214 , A61L2300/252 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/418 , C08G18/10 , C08G18/3206 , C08G18/3218 , C08G18/4833 , C08G18/771 , C08G18/8022 , C08G2230/00
摘要： A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing molecule retains the ability to undergo free radical polymerization after attachment of the bioactive agent thereto. The first polymerizing molecule is preferably biocompatible. The polymerizing molecule can, for example. be dihydroxyphenyl-L-alanine (DOPA) or tyrosine. The composition can also include a second component synthesized by reacting at least one core molecule having a plurality of reactive hydrogen groups with at least one multi-isocyanate functional molecule to create a conjugate including terminal isocyanate groups. The conjugate molecule is reacted with a second polymerizing molecule that is adapted to undergo a free radical polymerization. The second polymerizing molecule includes a reactive hydrogen to react with the isocyanate groups of the conjugate. The second polymerizing molecule retains the ability to undergo the free radical polymerization after reaction with the conjugate. In several embodiments, the first polymerizing molecule and the second polymerizing molecule are the same and dihydroxyphenyl-L-alanine (DOPA) or tyrosine.
摘要翻译： 组合物包含共价连接到适于进行自由基聚合的第一聚合分子的至少一种生物活性剂。 第一聚合分子保留在生物活性剂附着后进行自由基聚合的能力。 第一聚合分子优选是生物相容的。 聚合分子可以，例如。 是二羟基苯基-L-丙氨酸（DOPA）或酪氨酸。 组合物还可以包括通过使具有多个反应性氢基团的至少一个核心分子与至少一个多异氰酸酯官能分子反应以产生包含末端异氰酸酯基团的缀合物而合成的第二组分。 共轭分子与适于进行自由基聚合的第二聚合分子反应。 第二聚合分子包括与偶联物的异氰酸酯基反应的反应性氢。 第二聚合分子保留在与缀合物反应后进行自由基聚合的能力。 在几个实施方案中，第一聚合分子和第二聚合分子是相同的，并且是二羟基苯基-L-丙氨酸（DOPA）或酪氨酸。
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公开(公告)号：US20110136225A1
公开(公告)日：2011-06-09
申请号：US12961309
申请日：2010-12-06
申请人： Gordana Vunjak-Novakovic , Warren Grayson , Qun Wan , Donald Freytes , Amandine Godier-Furnémont , Nina Tandon , Keith Yeager , George Eng , Sarindr Bhumiratana , Robert Maidhof
发明人： Gordana Vunjak-Novakovic , Warren Grayson , Qun Wan , Donald Freytes , Amandine Godier-Furnémont , Nina Tandon , Keith Yeager , George Eng , Sarindr Bhumiratana , Robert Maidhof
CPC分类号： C12M23/44 , C12M21/08 , C12M23/42 , C12M23/46 , C12M23/58 , C12M25/14 , C12M29/10 , C12M29/20 , C12M35/02 , C12M41/46 , C12M41/48
摘要： Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a mechanical transmission module, a gas exchange module, a temperature module, a humidity module and/or a CO2 module, among others. The bioreactor and functional modules can include standard or universal connectors to facilitate connection and movement of modules. The bioreactor system can be controlled and/or monitored by a controller that can individually identify and control each connected module and that can be adapted to collect signal data from sensors embedded in any of the modules.
摘要翻译： 公开了生物反应器装置，系统和方法。 生物反应器系统可以包括可以单独控制和可识别的一个或多个生物反应器模块。 生物反应器模块可以连接到一个或多个功能模块，例如泵模块，刺激信号发生模块，马达模块，机械传动模块，气体交换模块，温度模块，湿度模块和/或二氧化碳 模块等。 生物反应器和功能模块可以包括标准或通用连接器，以便于模块的连接和移动。 生物反应器系统可以被控制器控制和/或监控，所述控制器可以单独地识别和控制每个连接的模块，并且可以适于从嵌入在任何模块中的传感器收集信号数据。
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