公开(公告)号：US08415462B2

公开(公告)日：2013-04-09

申请号：US12600460

申请日：2008-01-29

申请人： Nathalie Sylvestre ,  Eric Jacobs

发明人： Nathalie Sylvestre ,  Eric Jacobs

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12Q1/00 ,  C12P21/06

CPC分类号： C12N15/85 ,  C07K14/005 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2760/20122 ,  C12N2840/20

摘要： The present invention provides novel peptides of specified sequence and their use as a signal peptide or a membrane-anchoring peptide. It also relates to chimeric polypeptide comprising one or more such peptides and a polypeptide of interest as well as nucleic acid molecules, vectors, infections vital particles and host cells encoding such peptides and chimeric polypeptides. The present invention also relates to a pharmaceutical composition comprising such elements and a pharmaceutically acceptable vehicle. The present invention also provides a method for recumbently producing a polypeptide using such peptides, especially for directing expression of a polypeptide of interest extracellularly or anchored at the surface of the plasma membrane.

摘要翻译： 本发明提供具有特定序列的新型肽及其作为信号肽或膜 - 锚定肽的用途。 它还涉及包含一种或多种此类肽和感兴趣多肽以及核酸分子，载体，感染重要颗粒和编码这些肽和嵌合多肽的宿主细胞的嵌合多肽。 本发明还涉及包含这些元件和药学上可接受的载体的药物组合物。 本发明还提供了一种使用这些肽沉降产生多肽的方法，特别是用于引导细胞外或锚定在质膜表面的感兴趣多肽的表达。

公开(公告)号：US20060282331A1

公开(公告)日：2006-12-14

申请号：US11397829

申请日：2006-04-03

申请人： Eric Jacobs

发明人： Eric Jacobs

IPC分类号： G06Q20/00 ,  G06G1/14

CPC分类号： G07G1/12 ,  G06Q20/203 ,  G07G1/0054 ,  G07G1/145

摘要： An apparatus and method for self-checkout of non-bar coded items is provided. The apparatus includes a PLU entry device, a PLU database and a processing unit. The PLU entry device includes a display and a GUI. The GUI provides on the display a predetermined image corresponding to a non-bar coded item, and means for the user to select the predetermined image of the non-bar coded item. The PLU entry device supplies a PLU corresponding to the non-bar coded item selected by the user. The processing unit uses the PLU supplied by the PLU entry device to retrieve a price of the selected non-bar coded item from the PLU database. A GUI editor may also be provided for configuring the GUI for non-bar coded items. The processing unit may maintain for each item a count of the number of units of the item sold within a predetermined period of time. The processing unit also may maintain a list of most frequently sold items. The image of at least one item on the list is provided on a selected display screen. The processing unit may update the display screen when the list of most frequently sold items changes. An image of a generic category of items may be provided on the display. The displayed image of the generic category is selected by the user to view images of respective items in the generic category.

摘要翻译： 提供了一种用于非条形编码项目的自我检出的装置和方法。 该设备包括PLU输入设备，PLU数据库和处理单元。 PLU输入设备包括显示器和GUI。 GUI在显示器上提供与非条形编码项目相对应的预定图像，以及用于用户选择非条形编码项目的预定图像的装置。 PLU输入设备提供与用户选择的非条形编码项相对应的PLU。 处理单元使用PLU输入设备提供的PLU从PLU数据库中检索所选择的非条形编码项目的价格。 还可以提供用于配置用于非条形编码项目的GUI的GUI编辑器。 处理单元可以为每个项目维护在预定时间段内出售的物品的单元数量的计数。 处理单元还可以维护最常销售物品的列表。 在所选择的显示屏幕上提供列表中至少一个项目的图像。 当最频繁出售的物品的列表改变时，处理单元可以更新显示屏幕。 可以在显示器上提供项目的通用类别的图像。 通用类别的显示图像由用户选择以查看通用类别中各个项目的图像。

公开(公告)号：US5834237A

公开(公告)日：1998-11-10

申请号：US714070

申请日：1996-10-07

申请人： Eric Jacobs ,  Nathalie Silvestre ,  Ernst Schweinbryber

发明人： Eric Jacobs ,  Nathalie Silvestre ,  Ernst Schweinbryber

IPC分类号： C12N15/09 ,  C12N1/19 ,  C12N15/81 ,  C12P21/02 ,  C12R1/645 ,  C12P21/06

CPC分类号： C12N15/815

摘要： The present invention relates to a system for producing a protein of interest in a host cell comprising the combined use of two expression cassettes, one of which is for expressing a useful DNA fragment controlled by a thiamine-regulable promoter region, while the other is for expression an activator gene. The present invention also concerns expression cassettes comprising a useful DNA fragment controlled by a promoter region derived from the Schizosaccharomyces pombe pho-4 gene, as well as the vectors and cells comprising such an expression cassette. A novel method for the production of a useful protein is also provided.

摘要翻译： PCT No.PCT / FR95 / 00269 Sec。 371日期1996年10月7日第 102（e）日期1996年10月7日PCT 1995年3月9日PCT公布。 WO95 / 24491 PCT出版物 日期1995年9月14日本发明涉及一种用于在宿主细胞中产生感兴趣的蛋白质的系统，包括组合使用两个表达盒，其中之一用于表达由硫胺素可调节启动子区域控制的有用DNA片段， 而另一个用于表达激活基因。 本发明还涉及包含由源自粟酒裂殖酵母粟属pho-4基因的启动子区控制的有用DNA片段的表达盒以及包含这种表达盒的载体和细胞。 还提供了一种生产有用蛋白质的新方法。

公开(公告)号：US07328170B2

公开(公告)日：2008-02-05

申请号：US10364838

申请日：2003-02-11

申请人： Eric Jacobs ,  Iouri Kloubakov ,  Bruce McVicar ,  Thierry Leroux-Demers

发明人： Eric Jacobs ,  Iouri Kloubakov ,  Bruce McVicar ,  Thierry Leroux-Demers

IPC分类号： G06G1/12 ,  G06Q20/00

CPC分类号： G07G1/0036 ,  G06Q20/20 ,  G06Q20/202 ,  G06Q20/204 ,  G06Q20/206 ,  G06Q30/02 ,  G07G1/0054 ,  G07G1/14 ,  G07G3/00 ,  H04N7/181

摘要： A customer self-checkout system includes one or more checkout stations and multiple supervisor terminals. The supervisor terminals provide support to, and control over, the self-checkout system and checkout stations. The supervisory terminals may be wireless terminals that can capture self-checkout customer identification information including signatures, fingerprints, images, and other forms of identification.

摘要翻译： 客户自检系统包括一个或多个检验站和多个监督终端。 主管终端为自助结帐系统和结帐站提供支持和控制。 监控终端可以是可以捕获包括签名，指纹，图像和其他形式的识别的自签名客户识别信息的无线终端。

公开(公告)号：US20070118254A1

公开(公告)日：2007-05-24

申请号：US11536128

申请日：2006-09-28

申请人： Greg Barnes ,  Eileen Horbury ,  Eric Jacobs ,  Kenneth Buckman

发明人： Greg Barnes ,  Eileen Horbury ,  Eric Jacobs ,  Kenneth Buckman

IPC分类号： G06F17/00

CPC分类号： G05D1/0858 ,  B64C27/57

摘要： A flight control system for a helicopter having a main rotor and a tail rotor is provided. The flight control system includes an automatic rotor speed control being configured to transition the main rotor and the tail rotor between a high speed and a low speed based upon a plurality of received information without requiring any pilot action, the plurality of received information comprising height above ground level, knot indicated air speed, outside air temperature, barometric altitude, pressure altitude, density altitude, and an engine operational status.

摘要翻译： 提供了一种具有主转子和尾转子的直升机飞行控制系统。 飞行控制系统包括自动转子速度控制，其被配置为基于多个接收到的信息在高速和低速之间转换主转子和尾部转子，而不需要任何导向动作，所述多个接收信息包括高度 地面水平，结指示空气速度，外部空气温度，气压高度，压力高度，密度高度和发动机运行状态。

公开(公告)号：US06372443B1

公开(公告)日：2002-04-16

申请号：US08604986

申请日：1996-03-13

申请人： Eric Jacobs ,  Nathalie Silvestre ,  Bruno Mougin ,  Odette Bissardon ,  Michel Jolivet

发明人： Eric Jacobs ,  Nathalie Silvestre ,  Bruno Mougin ,  Odette Bissardon ,  Michel Jolivet

IPC分类号： G01N3353

CPC分类号： C07K14/45 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/02 ,  Y10S435/962

摘要： The present invention provides a reagent for the detection or monitoring of a Toxoplasma gondii infection, which includes as a reactive substance a truncated Toxoplasma gondii P30 protein in which all of the hydrophobic C-terminal region of the native protein starting with the amino acid positioned after the amino acid 299 (SEQ ID NO: 1) has been deleted and all of the region of the native protein having the sequence starting with amino acid 31 and ending with the amino acid 299 (SEQ ID NO: 1) is contained. The present invention further describes methods of screening for anti-Toxoplasma antibodies in a biological sample.

摘要翻译： 本发明提供了一种用于检测或监测弓形虫感染的试剂，其包括作为活性物质的截短弓形弓形体P30蛋白，其中天然蛋白质的所有疏水C末端区域以位于其后的氨基酸开始 已经缺失氨基酸299（SEQ ID NO：1），并且包含具有以氨基酸31开始并以氨基酸299（SEQ ID NO：1）结尾的序列的天然蛋白质的所有区域。 本发明还描述了在生物样品中筛选抗弓形体抗体的方法。

公开(公告)号：US20220068145A1

公开(公告)日：2022-03-03

申请号：US17412555

申请日：2021-08-26

申请人： Michael A. Cummings ,  Eric Jacobs

发明人： Michael A. Cummings ,  Eric Jacobs

IPC分类号： G08G5/00 ,  H04W4/021 ,  H04W4/42 ,  H04W4/029

摘要： Embodiments of the present disclosure provide a system, device and method for collecting, processing, correcting and employing positional vehicle data broadcast by aircraft and/or other vehicles to improve airport and related vehicle operations and tracking. In various embodiments, an IOT sensor subsystem comprising a detection unit is secured at or near an airport and includes one or more antennae, one or more sensors and a processing unit for analyzing the data and producing beneficial output.

公开(公告)号：US06326350B1

公开(公告)日：2001-12-04

申请号：US08867921

申请日：1997-06-03

申请人： Eric Jacobs ,  Michèle LeGrain ,  Véronique Mazarin ,  Bernadette Bouchon-Theisen ,  Anthony B. Schryvers ,  Marie-Aline Bloch

发明人： Eric Jacobs ,  Michèle LeGrain ,  Véronique Mazarin ,  Bernadette Bouchon-Theisen ,  Anthony B. Schryvers ,  Marie-Aline Bloch

IPC分类号： C07K1422

CPC分类号： C07K14/22 ,  C07K14/70582 ,  C07K16/1217

摘要： The subject of the present invention is a DNA fragment which encodes a protein capable of being recognised by an antiserum against the transferrin receptor of the strain IM2394 or IM2169 of N. meningitidis as well as a process for producing the said protein by a recombinant route. By way of example, such a DNA fragment encodes the tbp1 subunit of the strain IM2394 or IM2169 or the tbp2 subunit of the strain IM2394 or IM2169.

摘要翻译： 本发明的主题是编码能够被来自脑膜炎奈瑟氏球菌的IM2394或IM2169的转铁蛋白受体的抗血清识别的蛋白质的DNA片段，以及通过重组途径制备所述蛋白质的方法。 举例来说，这样的DNA片段编码菌株IM2394或IM2169或菌株IM2394或IM2169的tbp2亚基的tbp1亚基。

公开(公告)号：US06306625B1

公开(公告)日：2001-10-23

申请号：US08823578

申请日：1997-03-25

申请人： Eric Jacobs ,  Apolonia Rutgers

发明人： Eric Jacobs ,  Apolonia Rutgers

IPC分类号： C12N1509

CPC分类号： C07K14/005 ,  C12N15/81 ,  C12N2730/10122

摘要： The present invention provides a method for obtaining expression of a mixed hepatitis B surface antigen particle, e.g., a particle of mixed polypeptide composition, in yeast. Also disclosed is a method for obtaining multimeric structures presenting two or more polypeptides by expression in yeast as fusion proteins with the S antigen of HBsAg.

摘要翻译： 本发明提供了在酵母中获得混合的乙型肝炎表面抗原颗粒（例如混合多肽组合物的颗粒）的表达的方法。 还公开了通过在酵母中表达作为与HBsAg的S抗原的融合蛋白的两种或多种多肽的多聚体结构的方法。

公开(公告)号：US20070122062A1

公开(公告)日：2007-05-31

申请号：US11290315

申请日：2005-11-30

申请人： Eric Jacobs

发明人： Eric Jacobs

IPC分类号： G06K9/54

CPC分类号： G06K9/00993

摘要： A method and computer program enable the electronic capture and archiving of portions of printed publications for electronic searching and retrieval via a computer network. Employment-related sections of a plurality of printed publications are scanned to create a master digital image for each publication. Each master image is surveyed by an operator to identify locations of individual articles and advertisements contained in the image. A plurality of specific images are created from each master image, wherein each specific image contains a single article or advertisement. An operator defines a category, subcategory, and geographic location of each specific image, and each image is processed by optical character recognition software to determine text contained in the image. An end user searches the articles and advertisements according to category, subcategory, geographic location, and text, and views each specific image matching the user's search.

摘要翻译： 一种方法和计算机程序使得能够通过计算机网络电子捕获和归档印刷出版物的部分用于电子搜索和检索。 扫描多个印刷出版物的就业相关部分以为每个出版物创建主数字图像。 每个主图像由操作者进行调查，以识别图像中包含的各个物品和广告的位置。 从每个主图像创建多个特定图像，其中每个特定图像包含单个物品或广告。 操作员定义每个特定图像的类别，子类别和地理位置，并且每个图像由光学字符识别软件处理以确定包含在图像中的文本。 最终用户根据类别，子类别，地理位置和文字搜索文章和广告，并查看与用户搜索匹配的每个特定图像。