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1.发明授权公开(公告)号：US07545504B2
公开(公告)日：2009-06-09
申请号：US11539275
申请日：2006-10-06
CPC分类号： G01N21/45 , A61B3/102 , A61B3/1225 , A61B5/0066 , G01B9/02004 , G01B9/02027 , G01B9/02044 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01N21/23 , G01N2021/1787
摘要： Optical imaging systems are provided including a light source and a depolarizer. The light source is provided in a source arm of the optical imaging system. A depolarizer is coupled to the light source in the source arm of the optical imaging system and is configured to substantially depolarize the light from the light source. Related methods and controllers are also provided.
摘要翻译： 提供了包括光源和消偏振器的光学成像系统。 光源设置在光学成像系统的源臂中。 去偏振器耦合到光学成像系统的源极臂中的光源，并且被配置为基本上使来自光源的光去极化。 还提供了相关方法和控制器。
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2.发明授权Optical coherence imaging systems having a reduced effective linewidth and methods of using the same 有权具有降低的有效线宽的光学相干成像系统及其使用方法公开(公告)号：US09562856B2
公开(公告)日：2017-02-07
申请号：US13168286
申请日：2011-06-24
CPC分类号： G01B9/02044 , A61B3/102 , A61B3/1225 , A61B5/0066 , G01B9/02004 , G01B9/02007 , G01B9/02008 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Frequency domain optical coherence imaging systems have an optical source, an optical detector and an optical transmission path between the optical source and the optical detector. The optical transmission path between the optical source and the optical detector reduces an effective linewidth of the imaging system. The optical source may be a broadband source and the optical transmission path may include a periodic optical filter.
摘要翻译： 频域光学相干成像系统在光源和光学检测器之间具有光源，光学检测器和光传输路径。 光源和光学检测器之间的光传输路径降低了成像系统的有效线宽。 光源可以是宽带源，并且光传输路径可以包括周期性滤光器。
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3.发明授权Methods, systems and computer program products for analyzing three dimensional data sets obtained from a sample 有权用于分析从样本获得的三维数据集的方法，系统和计算机程序产品公开(公告)号：US07869663B2
公开(公告)日：2011-01-11
申请号：US11461083
申请日：2006-07-31
CPC分类号： A61B3/1225 , A61B3/102 , G01N21/4795 , G06T7/33 , G06T2207/30004
摘要： Methods of analyzing three dimensional data sets obtained from a sample over time are provided. A first three dimensional data set is obtained from the sample at a first time. A first volume intensity projection (VIP) image is created from the first three dimensional data set. One or more first landmarks are identified and registered in the first VIP image. A second three dimensional data set is obtained from the sample at a second time, different from the first time. A second VIP image is created from the second three dimensional data set. The one ore more first landmarks are identified and registered in the second VIP image. The first and second VIP images are aligned based on the registered one or more first landmarks in the first and second VIP images. Related systems and computer program products are also provided.
摘要翻译： 提供了一种随时间分析从样本获得的三维数据集的方法。 在第一时间从样本获得第一三维数据集。 从第一三维数据集创建第一体积强度投影（VIP）图像。 在第一VIP图像中识别并登记一个或多个第一地标。 第二个三维数据集从第二次获得，与第一次不同。 从第二个三维数据集创建第二个VIP图像。 在第二个VIP图像中识别并注册了一个更多的第一个地标。 基于第一和第二VIP图像中登记的一个或多个第一地标对准第一和第二VIP图像。 还提供了相关系统和计算机程序产品。
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4.发明授权Spectral domain phase microscopy (SDPM) dual mode imaging systems and related methods and computer program products 有权光谱相位显微镜（SDPM）双模成像系统及相关方法和计算机程序产品公开(公告)号：US07847951B2
公开(公告)日：2010-12-07
申请号：US12477949
申请日：2009-06-04
CPC分类号： A61B3/13 , A61B3/102 , A61B5/0066 , A61B5/0073 , G01B9/02018 , G01B9/02021 , G01B9/02025 , G01B9/02044 , G01B9/02083 , G01B9/0209 , G01B9/02091 , G01N21/4795
摘要： Some embodiments of the present invention provide optical coherence tomography systems including an OCT engine and a processor. The OCT engine is configured to provide both standard OCT imaging and spectral domain phase microscopy (SDPM) imaging. The processor is coupled to the OCT engine and is configured to use a first signal processing method when the OCT engine is configured to provide standard OCT imaging and a second signal processing method when the OCT engine is configured to provide SDPM imaging. Related methods and computer program products are also provided.
摘要翻译： 本发明的一些实施例提供包括OCT引擎和处理器的光学相干断层摄影系统。 OCT引擎配置为提供标准OCT成像和光谱域相位显微镜（SDPM）成像。 处理器耦合到OCT引擎，并且被配置为当OCT引擎配置为提供标准OCT成像时使用第一信号处理方法，并且当OCT引擎配置为提供SDPM成像时，使用第二信号处理方法。 还提供了相关方法和计算机程序产品。
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5.发明申请Methods, Systems and Computer Program Products for Analyzing Three Dimensional Data Sets Obtained from a Sample 有权用于分析样本中获得的三维数据集的方法，系统和计算机程序产品公开(公告)号：US20110075946A1
公开(公告)日：2011-03-31
申请号：US12959722
申请日：2010-12-03
IPC分类号： G06K9/32
CPC分类号： A61B3/1225 , A61B3/102 , G01N21/4795 , G06T7/33 , G06T2207/30004
摘要： Methods of analyzing three dimensional data sets obtained from a sample over time are provided. The methods include aligning first and second volume intensity projection (VIP) images based on at least one landmark in the first and second VIP images. The first and second VIP images are obtained from a first three dimensional data set obtained from the sample at a first time and a second three dimensional data set obtained from the sample at a second time, respectively.
摘要翻译： 提供了一种随时间分析从样本获得的三维数据集的方法。 所述方法包括基于第一和第二VIP图像中的至少一个地标来对准第一和第二体积强度投影（VIP）图像。 第一和第二VIP图像分别从第一次从样本获得的第一三维数据集和第二次从样本获得的第二三维数据集获得。
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6.发明授权Spectral domain phase microscopy (SDPM) dual mode imaging systems and related methods and computer program products 有权光谱相位显微镜（SDPM）双模成像系统及相关方法和计算机程序产品公开(公告)号：US07554669B2
公开(公告)日：2009-06-30
申请号：US11560175
申请日：2006-11-15
CPC分类号： A61B3/13 , A61B3/102 , A61B5/0066 , A61B5/0073 , G01B9/02018 , G01B9/02021 , G01B9/02025 , G01B9/02044 , G01B9/02083 , G01B9/0209 , G01B9/02091 , G01N21/4795
摘要： Some embodiments of the present invention provide optical coherence tomography systems including an OCT engine and a processor. The OCT engine is configured to provide both standard OCT imaging and spectral domain phase microscopy (SDPM) imaging. The processor is coupled to the OCT engine and is configured to use a first signal processing method when the OCT engine is configured to provide standard OCT imaging and a second signal processing method when the OCT engine is configured to provide SDPM imaging. Related methods and computer program products are also provided.
摘要翻译： 本发明的一些实施例提供包括OCT引擎和处理器的光学相干断层摄影系统。 OCT引擎配置为提供标准OCT成像和光谱域相位显微镜（SDPM）成像。 处理器耦合到OCT引擎，并且被配置为当OCT引擎配置为提供标准OCT成像时使用第一信号处理方法，并且当OCT引擎配置为提供SDPM成像时，使用第二信号处理方法。 还提供了相关方法和计算机程序产品。
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7.发明授权Methods, systems and computer program products for analyzing three dimensional data sets obtained from a sample 有权用于分析从样本获得的三维数据集的方法，系统和计算机程序产品公开(公告)号：US08442356B2
公开(公告)日：2013-05-14
申请号：US12959722
申请日：2010-12-03
CPC分类号： A61B3/1225 , A61B3/102 , G01N21/4795 , G06T7/33 , G06T2207/30004
摘要： Methods of analyzing three dimensional data sets obtained from a sample over time are provided. The methods include aligning first and second volume intensity projection (VIP) images based on at least one landmark in the first and second VIP images. The first and second VIP images are obtained from a first three dimensional data set obtained from the sample at a first time and a second three dimensional data set obtained from the sample at a second time, respectively.
摘要翻译： 提供了一种随时间分析从样本获得的三维数据集的方法。 所述方法包括基于第一和第二VIP图像中的至少一个地标来对准第一和第二体积强度投影（VIP）图像。 第一和第二VIP图像分别从第一次从样本获得的第一三维数据集和第二次从样本获得的第二三维数据集获得。
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8.发明授权公开(公告)号：US08374684B2
公开(公告)日：2013-02-12
申请号：US13281561
申请日：2011-10-26
IPC分类号： A61B6/00
CPC分类号： A61B3/14 , A61B3/1005 , A61B3/102 , A61B3/1208 , A61B3/1225 , A61B3/125 , G01B9/02028 , G01B9/0205 , G01B9/02057 , G01B9/02089 , G01B9/02091 , G01B2290/25 , G01B2290/35 , G01N21/4795
摘要： Portable optical coherence tomography (OCT) devices including at least one mirror configured to scan at least two directions are provided. The portable OCT devices are configured to provide a portable interface to a sample that can be aligned to the sample without repositioning the sample. Related systems are also provided.
摘要翻译： 提供了包括配置成扫描至少两个方向的至少一个反射镜的便携式光学相干断层摄影（OCT）装置。 便携式OCT设备被配置为向样本提供便携式接口，该样本可以与样品对准而不重新定位样品。 还提供了相关系统。
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9.发明申请公开(公告)号：US20120101373A1
公开(公告)日：2012-04-26
申请号：US13281561
申请日：2011-10-26
IPC分类号： A61B6/00
CPC分类号： A61B3/14 , A61B3/1005 , A61B3/102 , A61B3/1208 , A61B3/1225 , A61B3/125 , G01B9/02028 , G01B9/0205 , G01B9/02057 , G01B9/02089 , G01B9/02091 , G01B2290/25 , G01B2290/35 , G01N21/4795
摘要： Portable optical coherence tomography (OCT) devices including at least one mirror configured to scan at least two directions are provided. The portable OCT devices are configured to provide a portable interface to a sample that can be aligned to the sample without repositioning the sample. Related systems are also provided.
摘要翻译： 提供了包括配置成扫描至少两个方向的至少一个反射镜的便携式光学相干断层摄影（OCT）装置。 便携式OCT设备被配置为向样本提供便携式接口，该样本可以与样品对准而不重新定位样品。 还提供了相关系统。
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10.发明授权公开(公告)号：US07990541B2
公开(公告)日：2011-08-02
申请号：US12551782
申请日：2009-09-01
IPC分类号： G01B9/02
CPC分类号： G01B9/02044 , A61B3/102 , A61B3/1225 , A61B5/0066 , G01B9/02004 , G01B9/02007 , G01B9/02008 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Frequency domain optical coherence imaging systems have an optical source, an optical detector and an optical transmission path between the optical source and the optical detector. The optical transmission path between the optical source and the optical detector reduces an effective linewidth of the imaging system. The optical source may be a broadband source and the optical transmission path may include a periodic optical filter.
摘要翻译： 频域光学相干成像系统在光源和光学检测器之间具有光源，光学检测器和光传输路径。 光源和光学检测器之间的光传输路径降低了成像系统的有效线宽。 光源可以是宽带源，并且光传输路径可以包括周期性滤光器。
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