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    Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
    1.
    发明授权
    Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras 失效
    多功能和多功能基本神经营养因子，以及编码CHIMERAS的核酸和等离子体

    公开(公告)号：US5169764A

    公开(公告)日：1992-12-08

    申请号：US564929

    申请日：1990-08-08

    申请人： Eric M. Shooter ,  Ulrich Suter ,  Nancy Ip ,  Stephen P. Squinto ,  Mark E. Furth ,  Ronald M. Lindsay ,  George D. Yancopoulos

    发明人： Eric M. Shooter ,  Ulrich Suter ,  Nancy Ip ,  Stephen P. Squinto ,  Mark E. Furth ,  Ronald M. Lindsay ,  George D. Yancopoulos

    IPC分类号： A61K38/00 ,  A61K38/22 ,  A61P25/00 ,  C07K14/00 ,  C07K14/475 ,  C07K14/48 ,  C07K14/52 ,  C07K14/82 ,  C07K19/00 ,  C12N15/00 ,  C12N15/16 ,  C12N15/18 ,  C12P21/02 ,  C12Q1/68

    CPC分类号： C07K14/475 ,  C07K14/48 ,  C07K14/82 ,  C12Q1/6876 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/41 ,  C07K2319/75 ,  Y10S530/839 ,  Y10S930/12

    摘要： The present invention relates to chimeric neurotrophic factors which comprise at least a portion of a naturally occurring cellular factor and a portion of at least one other molecule such that the resulting chimeric molecule has neurotrophic activity. It is based, in part, on the discovery that chimeric molecules comprising portions of both NGF and BDNF are likely to possess neurotrotrophic activity, and in some cases exhibit a spectrum of activity larger than that of either parent molecule. It is further based on the discovery that chimeric molecules comprising neurotrophic factor sequences as well as additional peptide sequences may retain neurotrophic activity, and in some cases may exhibit a more potent activity than the parent factor. The chimeric neurotrophic factor molecules of the invention provide a number of advantages relative to naturally occurring neurotrophic factors. Chimeric neurotrophic factors may be used to provide, for example, the activity of two neurotrophic factors in a single molecule, or may serve as superagonists of an endogenous neurotrophic factor, thereby enabling an increased biological response at lower doses. Nucleic acids and plasmids encoding the chimeras are disclosed.

    摘要翻译： 本发明涉及嵌合神经营养因子，其包含至少一部分天然存在的细胞因子和至少一种其它分子的一部分，使得所得的嵌合分子具有神经营养活性。 其部分基于以下发现：包含NGF和BDNF两部分的嵌合分子可能具有神经营养活性，并且在一些情况下表现出比任一亲本分子更大的活性谱。 进一步基于以下发现：包含神经营养因子序列以及另外的肽序列的嵌合分子可以保留神经营养活性，并且在一些情况下可能表现出比母体因子更有效的活性。 本发明的嵌合神经营养因子分子相对于天然存在的神经营养因子提供了许多优点。 嵌合神经营养因子可用于提供例如单个分子中的两种神经营养因子的活性，或者可以作为内源性神经营养因子的增生因子，从而能够以较低剂量增加生物反应。 公开了编码嵌合体的核酸和质粒。

    Formulations containing astragalus extracts and uses thereof
    3.
    发明申请
    Formulations containing astragalus extracts and uses thereof 审中-公开
    含黄芪提取物及其用途的制剂

    公开(公告)号：US20070122501A1

    公开(公告)日：2007-05-31

    申请号：US10563533

    申请日：2004-06-25

    申请人： Calvin Harley ,  Allison Chin ,  Nancy Ip ,  Yung-huo Wong ,  David Miller-Martini

    发明人： Calvin Harley ,  Allison Chin ,  Nancy Ip ,  Yung-huo Wong ,  David Miller-Martini

    IPC分类号： A61K36/48 ,  A61K36/28

    CPC分类号： A61K36/481 ,  A61K36/71

    摘要： Formulations containing plant extracts, in particular Astragalus extracts, and their use in inducing telomerase activity in cells, are described. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in selected cells, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells. Also described are cosmetic formulations of such extracts for conditioning the skin.

    摘要翻译： 描述了含有植物提取物，特别是黄芪提取物及其在细胞中诱导端粒酶活性的用途的制剂。 这样的组合物包括药物，包括局部和营养制剂。 所述方法和组合物可用于治疗选择细胞中端粒酶活性增加的治疗疾病，例如HIV感染，各种退行性疾病以及急性或慢性皮肤疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和干细胞增殖。 还描述了用于调理皮肤的这种提取物的化妆品制剂。